- Soledad St. Hilaire - Nurse
- Owen Robinson - Officer Morton
- Tiffany Yvonne Cox - Gina
- Erik Rondell - Aggro Man
- Eve Sigall - Agatha
- Edward Fordham, Jr. - Kyle
- Blair Beeken - Wendy
- Olivia Macklin - Bambi
- Steve Howey - Jason
- Gloria Calderón Kellett - Patty
- Felice Heather Monteith - Nice Woman
- Tara Karsian - Principal Erica Brewer
- Deborah Theaker - Mrs. Bogle
- Beth Littleford - Doug's Wife
- Tom Virtue - Doug
- Louisa Abernathy - Old Lady
- David Douglas - Dan
- Amir M. Korangy - OBGYN
- Ed Asner - Abe Rifkin
- June Carryl - Angela
- Jen Kober - Rabbi
- Lynn Andrews - Female Teller
- Michole Briana White - Teri
- Lisa Schurga - Jana
- Renée Victor - Flo Gutierrez
- Beth Hoyt - Tracy
- Sunkrish Bala - Tracy's Husband
- Adora Soleil Bricher - Shandy Adams
- Ericka Kreutz - Ally Adams
- Greg Bryan - Sheriff
- Reatha Grey - Marva
- Jay Renshaw - Sebastian
- Bernardo Badillo - Bartender
- John Ennis - Slade
- Chris Aquilino - Tyler
- Josell Mariano - Dustin
- Jason Tobias - Lance
- Natalie Morales - Michelle Gutierrez
- Marc Evan Jackson - Jeff
- Justin James Farley - Male Nurse
- Sadie Stanley - Parker
- Rick Holmes - Andrew Peters
- Jere Burns - Howard Hastings
- Barry Livingston - Bernard
- Karen Maruyama - Marcy
- Frances Conroy - Eileen Wood
- Suzy Nakamura - Karen
- Telma Hopkins - Yolanda
- Brandon Scott - Nick Prager
- Keong Sim - Pastor Wayne
- Sarah Haruko - Hiker with Dog
- Diana Maria Riva - Detective Ana Perez
- Katey Sagal - Eleanor Hale
- Lily Knight - Linda
- Valerie Mahaffey - Lorna Harding
- Indi Star - Holy Harmony Dancer
- Marcus Brown - Officer Hernandez
- Umit Tayanc - Greek Businessman
- Heather Ashley Chase - Nurse Gina
- Elizabeth Kouri - Aliki Aivazis
- Turhan Troy Caylak - Dr. Kaan Abaci
- Staci Lynn Fletcher - Nurse Maureen
- Jason-Shane Scott - Shirtless Man
- Anthony M. Bertram - Hospital Cop
- Angela Fornero - Nurse Nicole
- Mike Rose - Nurse Michael
- Damian Washington - CT Scan Tech
- Kelly Hutchinson - Susan
- Garret Dillahunt - Glenn Moranis
- Jiavani - Amber, CT Tech
- Anjali Bhimani - Dr. Ashmani
- Goran Ivanovski - Male Mourner
- Steve Bannos - Older Male Usher
- Lee Garlington - Nurse Francine
- Ash T - ER Doctor
- Audrey Looye - Woman
- Rachelle Henry - Teenage Daughter
- Stephanie T. Keefer - New Nurse
- Eliza Shin - Dr. Tanner
- Ashley Holston - Kalina
- John Ales - Stavros
- Richard Pierre-Louis - Ice Cream Guy
- Leon Mandel - Hector
- Rudy Marquez - Spanish Doctor
- Elizabeth Allen Rosenbaum
- Silver Tree
- Jennifer Getzinger
- Kat Coiro
- Tamra Davis
- Geeta Patel
- Kelly Hutchinson
- Celeste Hughey
- Anthony King
- Kate Robin
- Rebecca Addelman
- Linda Cardellini
- Dan Dietz
- Christina Applegate
- Adam Blau
Linda Cardellini interpreta a Judy Hale en la serie.
Christina Applegate hace el papel de Jen Harding.
Frances Conroy interpreta a Eileen Wood en la serie.
James Marsden hace el papel de Ben Wood.
Luke Roessler hace el papel de Henry Harding.
Sam McCarthy hace el papel de Charlie Harding.
Capítulo disponible en las siguientes plataformas:
