- Soledad St. Hilaire - Nurse
- Owen Robinson - Officer Morton
- Tiffany Yvonne Cox - Gina
- Erik Rondell - Aggro Man
- Eve Sigall - Agatha
- Edward Fordham, Jr. - Kyle
- Blair Beeken - Wendy
- Olivia Macklin - Bambi
- Steve Howey - Jason
- Gloria Calderón Kellett - Patty
- Felice Heather Monteith - Nice Woman
- Tara Karsian - Principal Erica Brewer
- Deborah Theaker - Mrs. Bogle
- Beth Littleford - Doug's Wife
- Tom Virtue - Doug
- Louisa Abernathy - Old Lady
- David Douglas - Dan
- Amir M. Korangy - OBGYN
- Ed Asner - Abe Rifkin
- June Carryl - Angela
- Jen Kober - Rabbi
- Lynn Andrews - Female Teller
- Michole Briana White - Teri
- Lisa Schurga - Jana
- Renée Victor - Flo Gutierrez
- Beth Hoyt - Tracy
- Sunkrish Bala - Tracy's Husband
- Adora Soleil Bricher - Shandy Adams
- Ericka Kreutz - Ally Adams
- Greg Bryan - Sheriff
- Reatha Grey - Marva
- Jay Renshaw - Sebastian
- Bernardo Badillo - Bartender
- John Ennis - Slade
- Chris Aquilino - Tyler
- Josell Mariano - Dustin
- Jason Tobias - Lance
- Natalie Morales - Michelle Gutierrez
- Marc Evan Jackson - Jeff
- Justin James Farley - Male Nurse
- Sadie Stanley - Parker
- Rick Holmes - Andrew Peters
- Jere Burns - Howard Hastings
- Barry Livingston - Bernard
- Karen Maruyama - Marcy
- Frances Conroy - Eileen Wood
- Suzy Nakamura - Karen
- Telma Hopkins - Yolanda
- Brandon Scott - Nick Prager
- Keong Sim - Pastor Wayne
- Sarah Haruko - Hiker with Dog
- Diana Maria Riva - Detective Ana Perez
- Katey Sagal - Eleanor Hale
- Lily Knight - Linda
- Valerie Mahaffey - Lorna Harding
- Indi Star - Holy Harmony Dancer
- Marcus Brown - Officer Hernandez
- Umit Tayanc - Greek Businessman
- Heather Ashley Chase - Nurse Gina
- Elizabeth Kouri - Aliki Aivazis
- Turhan Troy Caylak - Dr. Kaan Abaci
- Staci Lynn Fletcher - Nurse Maureen
- Jason-Shane Scott - Shirtless Man
- Anthony M. Bertram - Hospital Cop
- Angela Fornero - Nurse Nicole
- Mike Rose - Nurse Michael
- Damian Washington - CT Scan Tech
- Kelly Hutchinson - Susan
- Garret Dillahunt - Glenn Moranis
- Jiavani - Amber, CT Tech
- Anjali Bhimani - Dr. Ashmani
- Goran Ivanovski - Male Mourner
- Steve Bannos - Older Male Usher
- Lee Garlington - Nurse Francine
- Ash T - ER Doctor
- Audrey Looye - Woman
- Rachelle Henry - Teenage Daughter
- Stephanie T. Keefer - New Nurse
- Eliza Shin - Dr. Tanner
- Ashley Holston - Kalina
- John Ales - Stavros
- Richard Pierre-Louis - Ice Cream Guy
- Leon Mandel - Hector
- Rudy Marquez - Spanish Doctor
- Elizabeth Allen Rosenbaum
- Silver Tree
- Jennifer Getzinger
- Kat Coiro
- Tamra Davis
- Geeta Patel
- Kelly Hutchinson
- Celeste Hughey
- Anthony King
- Kate Robin
- Rebecca Addelman
- Linda Cardellini
- Dan Dietz
- Christina Applegate
- Adam Blau
Linda Cardellini interpreta a Judy Hale en la serie.
Christina Applegate hace el papel de Jen Harding.
Frances Conroy hace el papel de Eileen Wood.
James Marsden interpreta a Ben Wood en la serie.
Luke Roessler interpreta a Henry Harding en la serie.
Sam McCarthy interpreta a Charlie Harding en la serie.
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