- Gary Busey - Ezra Burnham
- Mark Hamill - Dr. Sam Stein
- María Conchita Alonso - Marie Alexander
- Adam Baldwin - Major James Bowen
- Ronny Cox - Lt. Col. Lester Glade
- Joe Pantoliano - Stan Harbinger
- Callum Keith Rennie - Carlito
- David Warner - Inspector Harold Langford
- Mykelti Williamson - Dr. Michael Alders
- Stacy Keach - Cord van Owen
- Jennifer Beals - Robin Dysart
- Stephen Shellen - Wayne Haas
- Kim Cattrall - Rebecca Highfield
- Ralph Macchio - Dr. Neal Eberhardt
- C. Thomas Howell - Capt. Miles Davidow
- Harve Presnell - Greg Matheson
- Ron Perlman - Lt. Col. Brandon Grace
- M. Emmet Walsh - Sanford Vallé
- John Diehl - Joe
- Cary Elwes - Dr. John 'Jack' Percy Vilmorin York
- Dina Meyer - Dr. Rachel Harris
- Eugene Byrd - Ronnie Dell
- Michael Dorn - Pete Claridge
- Marina Sirtis - Olivia 'Liv' Kohler
- Alan Ruck - Howard Sharp
- Dennis Haysbert - Joshua Finch
- Amanda Plummer - Dr. Theresa Givens
- Thora Birch - Aggie Travers
- Emmanuelle Vaugier - Lisa Dobkins
- Saul Rubinek - Aaron Zgierski
- Lloyd Bridges - Col. Kress
- Frances Fisher - Lady Julia
- Robert Sean Leonard - Robby Archer
- Steven Bauer - Sgt. Waylon Dumar
- Rick Roberts - Andrew McLaren
- Robert Loggia - Justice Earl Clayton
- Diana Scarwid - Elizabeth Halsey
- Xander Berkeley - Terry McCammon
- Nora Dunn - Laura Sinclair
- Robert Foxworth - President Charles Halsey
- Joely Fisher - Amy
- Robert Patrick - Major John Skokes
- Jeffrey Jones - Dr. Scott Perkins
- Burt Young - Captain Parker
- Leland Orser - Dr. Arthur Zeller
- Beau Bridges - Dr. Simon Kress
- Fred Savage - Danny Martin
- Bob Gunton - Clute Nichols
- Julie Harris - Hera
- Annette O'Toole - Commander Lydia Manning
- Eric Keenleyside - Friedkin
- Kirsten Dunst - Joyce Taylor
- Jane Adams - Mona Bailey
- Leonard Nimoy - Thurman Cutler
- Wil Wheaton - Cadet
- Stephen McHattie - Dr. Sherrick
- Bruce Boxleitner - Senator Wyndom Brody
- Charles Martin Smith - Spencer Deighton
- Jon Tenney - Aidan Hunter
- Chris Elliott - Jack Parson
- David James Lewis - Will Carson
- Manny Coto
- Joel Goldsmith
Gary Busey interpreta a Ezra Burnham en la serie.
Mark Hamill interpreta a Dr. Sam Stein en la serie.
María Conchita Alonso interpreta a Marie Alexander en la serie.
Adam Baldwin hace el papel de Major James Bowen.
Ronny Cox interpreta a Lt. Col. Lester Glade en la serie.
Joe Pantoliano interpreta a Stan Harbinger en la serie.
Callum Keith Rennie interpreta a Carlito en la serie.
David Warner hace el papel de Inspector Harold Langford.
Mykelti Williamson interpreta a Dr. Michael Alders en la serie.
Stacy Keach interpreta a Cord van Owen en la serie.
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