- Amanda Abbington - Miss Josie Mardle
- Zoë Tapper - Ellen Love
- Amy Beth Hayes - Kitty Hawkins
- Calum Callaghan - George Towler
- Aidan McArdle - Lord Loxley
- Hannah Tointon - Violette Selfridge
- Kara Tointon - Rosalie Selfridge
- Kika Markham - Lois Selfridge
- Greg Austin - Gordon Selfridge
- Pippa Haywood - Flora Bunting
- Zoë Wanamaker - Princess Marie Wiasemsky de Bolotoff
- Leon Ockenden - Serge de Bolotoff
- Oliver Jackson-Cohen - Roderick Temple
- Deborah Cornelius - Miss Blenkinsop
- Adam Wilson - Gordon Selfridge (Young)
- Sacha Dhawan - Jimmy Dillon
- Amy Morgan - Grace Calthorpe Selfridge
- Will Payne - Tony Travers
- Malcolm Rennie - Fraser
- Polly Walker - Delphine Day
- Joséphine de la Baume - Valérie Maurel
- Robert Pugh - Lord Wynnstay
- Sacha Parkinson - Connie Hawkins
- Kelly Adams - Nancy Webb
- Cal MacAninch - Mr. Thackeray
- Sean Teale - Franco
- Mimî M. Khayisa - Matilda (Tilly) Brockless
- Jolyon Coy - Tom Gerrard / Gus
- Daniel Fine - Hotelier
- Ray MacAllan - Mr. Geoffries
- Simon Roberts - Priest
- Vincenzo Nicoli - Uncle Gio
- Sam Gittins - Alfie
- Paul Lancaster - Vicaire
- Michael Byers - Photographe
- Thomas Nelstrop - Michael
- Jonathan Howard - Ed
- Will Tudor - Frank Whitely
- Beverley Klein - Madame Lanvin
- Joseph Beattie - Mack Sennett (footage)
- Joseph Beattie - Mack Sennett
- Billy Barratt - Ralph Selfridge
- Alana Boden - Beatrice Selfridge
Frances O'Connor interpreta a Rose Selfridge en la serie.
Jeremy Piven interpreta a Harry Selfridge en la serie.
Ron Cook interpreta a Mr. Crabb en la serie.
Tom Goodman-Hill interpreta a Mr. Roger Grove en la serie.
Samuel West hace el papel de Frank Edwards.
Katherine Kelly interpreta a Lady Mae Loxley en la serie.
Trystan Gravelle interpreta a Victor Colleano en la serie.
Amanda Abbington interpreta a Miss Josie Mardle en la serie.
Amy Beth Hayes interpreta a Kitty Hawkins en la serie.
Hannah Tointon hace el papel de Violette Selfridge.
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