- Dallas Roberts - Dr. Jerome Oziel
- Jason Butler Harner - Det. Les Zoeller
- Leslie Grossman - Judalon Smyth
- Jeff Perry - Peter Hoffman
- Marlene Forte - Marta Cano
- Jade Pettyjohn - Jamie Pisarcik
- Tanner Stine - Perry Berman
- Kamy D. Bruder - Chauffeur
- Mara Casey - Marzi Eisenberg
- Max Hawksford - Coach
- Grayson Thorne Kilpatrick - Half-Assed Zombie (Trick-or-Treater)
- Jack Perry - Umpire
- Leanne Suter - CBS 2 Reporter
- Ashley Sutton - Wine Rep
- Jim Cody Williams - Old Man
- Enrique Murciano - Carlos Baralt
- Larry Clarke - Brian Andersen
- Drew Powell - Det. Tom Linehan
- Charlie Hall - Craig Cignarelli
- Rick Holmes - Randolph Wright
- Ron Bottitta - Chief Marvin Iannone
- Walter Belenky - Officer Czarnocki
- Justin Cuomo - Motorcycle Cop
- Anthony Elfonzia - Locksmith
- Brittany Freeth - Uniformed Officer
- Gregory Gast - Coroner
- Peter A. Hulne - Sergeant West
- Don O. Knowlton - Dan Stanton
- Gisela Kovach - Zsa Zsa Gabor
- Artie O'Daly - Officer Mo Angel
- Emory Ogletree II - Weight Coach
- Donovan Patton - Officer Butkus
- Jamie Tompkins - Real Estate Agent
- Alex Vaughan - Philip
- Gareth Williams - Det. Edmonds
- Clara York - Klara Wright
- Ari Graynor - Leslie Abramson
- Nathan Lane - Dominick Dunne
- Michael Gladis - Tim Rutten
- Gil Ozeri - Dr. William Vicary
- Salvator Xuereb - Robert Shapiro
- Brandon Santana - Tony
- Tessa Auberjonois - Dr. Laurel Oziel
- Blanca Araceli - Grandma Maria
- Robert Sean Burke - Cop #2
- Mario Cortez - Cop #1
- Brad Culver - Gerald Chaleff
- Rhied De Castro - Arnel Salvatierra
- Jake Elliott - Hayden Rodgers
- Jacob Figueroa - Edwards
- Stephen Friedrich - Young Reporter
- Roni Geva - Adoption Agent
- Layne Herrin - Glenn Stevens
- Kristin Lindquist - Joyce
- Chloe Oloren - Noelle
- Arthur Richardson - Guy
- Labrandon Shead - Miller
- Jess Weixler - Jill Lansing
- Anthony Turpel - Donovan Goodreau
- Catherine Carlen - Wealthy Socialite
- Joe Chambrello - Handsome Actor
- Paul Chirico - Other Police Officer
- Joseph Culp - Boat Captain
- Robert Dill - Police Officer
- Bradley Fisher - Movie Executive
- Kevin Gardner - Clerk
- Nicole Ghastin - Proctor
- Bernadette Guckin - Gun Range Worker
- Steve Hasley - Other Employee
- Lauren Lopez - Famous Actress
- Valerie Perri - Barbara
- Jeremy W. Roberts - Employee
- Juliet Rusche - Diane Vandermolen
- Orlando Pineda - Young José Menendez
- Belle Shouse - Young Kitty Menendez
- Hugo Medina - Edgardo Diaz
- Guilford Adams - Accountant
- Sally Brooks - Lula Mae
- John Colton - Justice of the Peace
- Matthew Gilmore - Photographer
- John Gloria - Contractor
- Jennifer Ingrum - Louise
- Julian Larach - Hustler
- Mandy Levin - Dr. Anne Heller
- Rob Mainord - Dr. Alan Fox
- Jeff Pride - Det. Mills
- Tom Simmons - Dean of Students
- Milana Vayntrub - Pam Bozanich
- Melissa Bailey - Juror #8
- Andrea Cañizares-Fernandez - Juror #4
- John Churchill - George
- Helen Duffy - Clerk
- Peggy Dunne - Juror #5
- David Lee Hess - Billy
- Matt Kaminsky - Sweeney's Attorney
- Mark Kelly - Norton
- Amie MacKenzie - Linda
- Ross Mackenzie - Judge Weisberg
- Miguel Pérez - Peter Cano
- Shaw Purnell - Ellen 'Lenny' Dunne
- Alex Rollins - Paul D'Emilio
- Amy Schloerb - Velma Smith
- Edward Singletary - Judge Burton Katz
- Zabeth Russell - Juror #1
- Ruben Vernier - Brian Eslaminia
- Jett Wilder - Dominique Dunne
- Tanya Clarke - Carrie
- Erin Coker - Doctor
- Christine Corpuz - Nurse
- Adam Dunnells - Inmate
- Vince Duvall - Joe
- Johnny James Fiore - Other Inmate
- Trae Ireland - OJ Simpson
- Jordan Matlock - Coach Wadlington
- Paul Adelstein - David Conn
- Patrick Breen - Alternate Juror
- Vicki Lawrence - Leigh
- Cinda Adams - Court Clerk (Menendez Trial)
- Tom Beyer - Robbie
- Stephen Bralver - Driver (Erik's Van)
- Andy Forrest - Charles Gessler
- Jim Grollman - Grant Walker
- Joshua Hoover - Andrew
- Diane Yang - Mary
- Heather Knobel - Carol Najera
- Anastasia Leddick - Lesley
- Jamison McDermott - Anna Eriksson
- Yvonne Miranda - Newscaster
- Andrew Oliveri - Barry Levin
- Reece Rios - Phil
- Stephen W. Schriver - Driver (Lyle's Van)
- Sam Skolnik - Isaac
- Christian Telesmar - Alfa Romeo Driver
- Juan Francisco Villa - Fr. Viera
- Gina Vitori - Gina
- Ryan Murphy
- Ian Brennan
Javier Bardem hace el papel de José Menendez.
Cooper Koch interpreta a Erik Menendez en la serie.
Nicholas Alexander Chavez hace el papel de Lyle Menendez.
Chloë Sevigny interpreta a Kitty Menendez en la serie.
Nathan Lane interpreta a Dominick Dunne en la serie.
Ari Graynor interpreta a Leslie Abramson en la serie.
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