- Brey Chanadet - Other Kid
- Nick Fisher - Young Jeffrey Dahmer
- Michael Beach - Det. Dennis Murphy
- Colby French - Patrick Kennedy
- Mac Brandt - Robert Rauth
- Shaun Brown - Tracy Edwards
- Grant Harvey - Rolf Mueller
- Penelope Ann Miller - Joyce Dahmer
- Josh Braaten - Young Lionel Dahmer
- Cameron Cowperthwaite - Steven Hicks
- Nigel Gibbs - Reverend Jesse Jackson
- Justin Stella - Derek
- Ken Lerner - Joe Zilber
- Michael Andrew Baker - Lionel's Lawyer
- Jesse Bush - Officer #1
- Thomas Crawford - Judge
- Colin Ford - Chazz
- Karole Foreman - Dottie
- Asa Germann - Blonde Jogger
- Matthew Gilmore - Officer #2
- Trilby Glover - Guidance Counselor
- Alex Hyde-White - Doctor
- Emma Kennedy - Denise
- Peter MacKenzie - Mr. Bertoglio
- Tenz McCall - Young David Dahmer
- David Theune - Math Teacher
- Ato Blankson-Wood - Aaron
- Chris Gann - Police Officer #1
- Joshua Edward Moore - CSI Investigator
- Mark Reininga - Young Police Officer
- Leanne Suter - On Camera Reporter
- Matthew Alan - Officer Gabrish
- Scott Michael Morgan - Officer Balcerzak
- Hope Banks - Mrs. Hempsill
- Rodney Burford - Tony Hughes
- Ken Clement - Wally the Butcher
- Tempany Deckert - Front Desk Police Officer
- Peter Holden - Police Officer
- Daniel Curtis Lee - Police Photographer
- Keylor Leigh - Department Store Clerk
- Travon McCall - Police Lieutenant
- Dia La Ren Nash - Sandra Smith
- Curtis Nelson II - Paramedic #1
- Teshi Thomas - Nicole Childress
- Vince Hill-Bedford - Steven Tuomi
- Blake Cooper Griffin - Charles
- Mark Atteberry - Dr. Park Dietz - Psychologist
- Hollie Bahar - Field Surgeon
- Fiona Bishop - Yearbook Girl
- Aaron Coleman - Dean of Students
- Brie Eley - Clinician
- Isaac Faulkner - Dan
- Michael Germant - Seth
- Brittany Giles - Tina
- Steve Hasley - Photographer
- John Ahle Kellar - Doug Brozovsky
- Eugene Ko - Yearbook Guy
- Teddy Margas - Sticky Ricky
- Carson Zone - Tanner
- Dyllón Burnside - Ronald Flowers
- Matt Cordova - Detective Rauss
- Skyler Bible - Richard Guerrero
- Ivar Brogger - Judge
- Ron Bush - Jeffery’s Lawyer
- Crystal Coney - Nurse
- Lacy Diamond - Prisoner #1
- Dion LaMarr Harvey - Prisoner #2
- Ken Ivy - African American Man
- Phet Mahathongdy - Somdy Sinthasomphone
- Ben Scott - Bus Driver
- Mark Weiler - Officer
- Karen Malina White - Shirley Hughes
- Karl Makinen - Officer Clyde Reynolds
- Noel Arthur - Doctor
- DaShawn Barnes - Rita Isbell
- Bruce Beatty - Dr. Larry Weeks
- Christopher Bencomo - Manny
- Anissa Borrego - Cashier
- Jared DeBusk - Rico
- Jordan Michael Green - Hairstylist
- Cheryl Francis Harrington - Shirley’s Mother
- Taneka Johnson - Pediatrics Nurse
- Caroline Klidonas - Makeup Artist
- Eva La Dare - Delivery Nurse
- Amy Mack - Barbara Hughes
- Brandon Papo - Male Employee
- Arthur Richardson - Manager
- John Shartzer - Marcus
- Michael Anthony Spady - Rufus
- Matt Steele - Duane
- Keanush Tafreshi - Denim Employee #1
- Nikea Gamby-Turner - Mildred Lindsey
- David Barrera - Chief Arreola
- Brandon Black - Dean Vaughn
- Raphael Sbarge - Mayor John Norquist
- Jacob Chattman - Paul Myers
- Maurice Demus - Jacob
- Stephanie Erb - Susan
- Clark Moore - Deputy Chief
- Scott Thomas Reynolds - Police Officer #2
- Raymond Watanga - Sopa Princewill
- Jacob Zukowski - Joseph Bradehoft
- Tom Virtue - Father Hecker
- Ava Ticotin - Janie Hagen
- Rosemary Thomas - Catherine Straughter
- Spencer Squire - Nick
- Tony Robinette - Donald Bradehoft
- Jordan Wall - Darryl
- Jonathan Stanley - Officer Krause
- Paul Zies - Tattooed Prisoner
- Jim McCaffree - Sheriff - 1957
- Eric Normington - Gavin
- Michael Adler - Judge Lawrence Gram
- Carlos Arellano - Bailiff
- Molly Baker - Audience Member
- Serene Branson - News Correspondent
- Markina Brown - Fresno Reporter #2
- Demi Castro - Geraldo Rivera
- Chase Fein - Police Officer #2
- Vanessa Giordano - Fresno Reporter #1
- Horace Gold - Isaac Richards
- Arye Gross - Gerald Boyle
- Rodney J. Hobbs - African American Sergeant
- Bobbie Lee Jr. - J.W. Smith
- Shane Kerwin - Ed Gein
- Ericka Kreutz - Female Sergeant
- Mercy Malick - Milwaukee Reporter #2
- Ed Mattiuzzi - Milwaukee Reporter #3
- Danny Max - Fresno Reporter #3
- Keyla McNeely - Dorothy Straughter
- Phil Biedron - Portage Prison Guard
- J. Paul Boehmer - Larry King
- David Bowe - Russell Goldstein
- Adwin Brown - Dennis
- Kyle Butenhoff - Ron
- Celestial - Dana
- Sarah Chang - Emily Soo
- Bill Chott - MPA President
- Robert DeSanti - Officer #1
- Matthew Downs - Officer Melnick
- Adam Dunnells - White Prisoner
- Leroy Edwards III - Osvaldo Durruthy
- Kareem Ferguson - Lemar
- Britt George - Portage Prison Guard #3
- John Grady - Barry Goldman
- Jake Green - Officer Kelly
- Jackson Hurst - Stone Phillips
- Doug Long - Officer #2
- Furly Mac - Christopher Scarver
- Verton R. Banks - Larry King
- Dominic Burgess - John Wayne Gacy
- Chris Greene - Chaplain Adams
- Linda Park - Julie Yang
- Troy Blendell - Roy Ratcliffe
- Scott Broderick - Warden Jeff Endicott
- Austin Cauldwell - Rick
- Grant Davis - Judge Daniel George
- Patrick Day - Chaplain Berkum
- Nicole Lynn Evans - Prison Librarian
- Roslyn Gentle - Coroner
- Jeff Harms - Jesse Anderson
- Kiff VandenHeuvel - Frank Currier
- Jay Jackson - Newscaster
- Matt Kaminsky - Walter Jacobson
- David Kelsey - Robert Fennig, Attorney
- Antonio David Lyons - Pastor
- Anthony Omari - Prisoner
- Amanda Reed - Linda
- David Rockwell - Statesville Warden
- Rachel Winfree - Woman
- Rachel Imbriglio
- Tanase Popa
- Regis Kimble
- Sara Stelwagen
- Todd Nenninger
- Todd Kubrak
- Jamie Hardt
- Amanda Beggs
- Jacob McNaughton
- Nick Cave
- Warren Ellis
- Noel Vought
Evan Peters interpreta a Jeffrey Dahmer en la serie.
Antonio David Lyons interpreta a Pastor en la serie.
Richard Jenkins interpreta a Lionel Dahmer en la serie.
Alex Hyde-White interpreta a Doctor en la serie.
Molly Ringwald interpreta a Shari Dahmer en la serie.
Michael Learned interpreta a Catherine Dahmer en la serie.
Niecy Nash-Betts hace el papel de Glenda Cleveland.
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