- Sheryl Lee Ralph - Dee Mitchell
- Shar Jackson - Niecy Jackson
- Countess Vaughn - Kimberly Ann Parker
- Fredro Starr - Quinton 'Q' Brooks
- Ray J - Dorian Long
- Andrew Keegan - Matt Tarses
- Lee Chamberlin - Mrs. Leveaux
- Golden Brooks - Maya Wilkes
- Maurice Greene - Percy
- Ajai Sanders - Lisa
- Walter Jones - Jay
- Lynn Hamilton - Ruth Mitchell
- Lil' Kim - Diamond
- Jazsmin Lewis - Lanae Foster
- Chrystee Pharris - Girl #1
- Bree Turner - Brenda
- Mo'Nique - Nikki Parker
- Selwyn Ward - College Guy
- Orlando Brown - James
- Shad Moss - Ray-Ray
- Curtis Williams - Tony
- Jon Huertas - Antonio
- Clifton Powell - R.C.
- Olivia Brown - Barbara Lee
- Tyrese Gibson - Troy
- Nakia Burrise - Joy
- Kym Whitley - Gertrude Lowe
- Meagan Good - Nicole
- Brian J. White - Gabe
- Iona Morris - Sandy
- Sanaa Lathan - Ebony
- Master P - Patience
- Kenya Williams - Cleo
- Anna Maria Horsford - Diane Henderson
- Yolanda Snowball - Ms. Baker
- Vera Yell - Jasmine
- Jesika Reynolds - Reese
- Scott Hamm Duenas - Allen
- Richard Gant - Rev. Lovejoy
- Angell Conwell - Melony
- Shorty Mack - Nice
- Derek Luke - Ruckus
- Alexis Fields - Alicia
- Lahmard J. Tate - Jerome
- Chico Benymon - Lamont
- Karimah Westbrook - Shania Levy
- Tasha Taylor - Tiffany
- Tevin Campbell - Kevin
- Francesca P. Roberts - Maxine
- Jermaine Hopkins - The Kid
- Amy Gross - Patricia
- Judy Kain - The Cashier Woman
- Christian Coleman - Freddie
- Medusa - Lady Lunatic
- Brandy Norwood
Brandy Norwood interpreta a Moesha Mitchell en la serie.
William Allen Young hace el papel de Frank Mitchell.
Marcus T. Paulk interpreta a Myles Mitchell en la serie.
Lamont Bentley hace el papel de Hakeem Campbell.
Shar Jackson interpreta a Niecy Jackson en la serie.
Ray J hace el papel de Dorian Long.
Capítulo disponible en las siguientes plataformas:
