- Nyambi Nyambi - Samuel
- Jim Fitzgerald - Dealer
- Dan Aho - Steve
- Sarah Baker - Stacey
- Cole Jensen - Willie
- David Mazouz - Randy
- Jessy Hodges - Maura DuVall
- Tucker Albrizzi - Tucker
- Kathy Nagler - Dispatcher
- John O'Brien - Waiter
- Bill Stevenson - Bryce
- Rico E. Anderson - Man
- Bob Bledsoe - Luther
- Eliza Coyle - Waitress
- Burl Moseley - Ndugu
- Mike Siegel - Marty
- Christopher Gehrman - Clinton
- Benjamin King - David
- Rebecca Field - Jill
- Robert Gant - Kyle
- Kelly Mantle - Steven
- Keone Young - Abe
- Hana Mae Lee - Soo-Jin
- Kayden Kessler - Aaron
- Coby Ryan McLaughlin - Gianni
- William Sanderson - Dennis
- Sally Champlin - Diane
- John Charles Meyer - Dylan
- Alexander Arzu - Harry Potter
- Elsie Fisher - Fairy Princess
- Logan Kishi - Diktrom
- Gibson Bobby Sjobeck - Batman
- Brian Stepanek - Voltaire
- Rachel Brett - Babysitter
- Cathy Fielding - Jane Goodall
- Terry Finn - Eleanor Roosevelt
- Alan Gray - Galileo
- Mark Roman - Thomas Jefferson
- Steve Hytner - Principal Gilmartin
- Brendan Patrick Connor - George
- Kevin Brief - Al
- Isabella Crovetti - Cindy
- Sonya Eddy - Kay
- Ryan Malgarini - Matt
- Cole Sand - Satchel
- Laura Coover - Rebecca
- Marianne Muellerleile - Connie
- Haley Tju - Missy
- Nate Mooney - Oswald
- Robert Pescovitz - Man
- Diarra Kilpatrick - Amira
- Howard Hesseman - Otis
- Alexandra Hoover - Woman
- Keong Sim - Dr. Shufeldt
- Mike Jerome Putnam - James
- Josh Dean - Father Justin
- Betsy Zajko - Crystal
- Cerina Vincent - Desri
- Larisa Oleynik - Allison
- Davenia McFadden - Julie
- Savvy Crawford - Little Victoria
- T.J. Hoban - Anton
- Lamont Thompson - Andre
- June Squibb - Francine
- Francis Guinan - Jack Biggs
- Dave Allen - Tom
- Reginald VelJohnson - Brother Heywood
- Holly Robinson Peete - Christina
- Kathy Bates - Kay
- Susan Sarandon - J.C. Small
- Joel Murray - Dr. Jeffries
- Eric Allan Kramer - Officer Seely
- Jamie Denbo - Officer Soltz
- Jessica Chaffin - Allison
- Wallace Langham - Robert
- Jack McGee - Officer Gronski
- Casey Washington - Ramirez
- Ava Gaudet - Raven
- Kiara Muhammad - Krystal
- Amy Farrington - Karen
- Juliette Goglia - Frannie DuVall
- David Trainer
- Stephen Prime
- Steve Prime
- Victor Gonzalez
- Jason Alexander
- Phill Lewis
- Steve Joe
- Rob DesHotel
- Alex Herschlag
- Mark Gross
- Julie Bean
- Bill Daly
- Chuck Lorre
Marianne Muellerleile interpreta a Connie en la serie.
William Sanderson interpreta a Dennis en la serie.
Susan Sarandon interpreta a J.C. Small en la serie.
Melissa McCarthy interpreta a Molly Flynn en la serie.
Billy Gardell interpreta a Mike Biggs en la serie.
Reno Wilson interpreta a Carl McMillan en la serie.
Swoosie Kurtz interpreta a Joyce Flynn en la serie.
Katy Mixon interpreta a Victoria Flynn en la serie.
Louis Mustillo hace el papel de Vincent Moranto.
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