- Nyambi Nyambi - Samuel
- Jim Fitzgerald - Dealer
- Dan Aho - Steve
- Sarah Baker - Stacey
- Cole Jensen - Willie
- David Mazouz - Randy
- Jessy Hodges - Maura DuVall
- Tucker Albrizzi - Tucker
- Kathy Nagler - Dispatcher
- John O'Brien - Waiter
- Bill Stevenson - Bryce
- Rico E. Anderson - Man
- Bob Bledsoe - Luther
- Eliza Coyle - Waitress
- Burl Moseley - Ndugu
- Mike Siegel - Marty
- Christopher Gehrman - Clinton
- Benjamin King - David
- Rebecca Field - Jill
- Robert Gant - Kyle
- Kelly Mantle - Steven
- Keone Young - Abe
- Hana Mae Lee - Soo-Jin
- Kayden Kessler - Aaron
- Coby Ryan McLaughlin - Gianni
- William Sanderson - Dennis
- Sally Champlin - Diane
- John Charles Meyer - Dylan
- Alexander Arzu - Harry Potter
- Elsie Fisher - Fairy Princess
- Logan Kishi - Diktrom
- Gibson Bobby Sjobeck - Batman
- Brian Stepanek - Voltaire
- Rachel Brett - Babysitter
- Cathy Fielding - Jane Goodall
- Terry Finn - Eleanor Roosevelt
- Alan Gray - Galileo
- Mark Roman - Thomas Jefferson
- Steve Hytner - Principal Gilmartin
- Brendan Patrick Connor - George
- Kevin Brief - Al
- Isabella Crovetti - Cindy
- Sonya Eddy - Kay
- Ryan Malgarini - Matt
- Cole Sand - Satchel
- Laura Coover - Rebecca
- Marianne Muellerleile - Connie
- Haley Tju - Missy
- Nate Mooney - Oswald
- Robert Pescovitz - Man
- Diarra Kilpatrick - Amira
- Howard Hesseman - Otis
- Alexandra Hoover - Woman
- Keong Sim - Dr. Shufeldt
- Mike Jerome Putnam - James
- Josh Dean - Father Justin
- Betsy Zajko - Crystal
- Cerina Vincent - Desri
- Larisa Oleynik - Allison
- Davenia McFadden - Julie
- Savvy Crawford - Little Victoria
- T.J. Hoban - Anton
- Lamont Thompson - Andre
- June Squibb - Francine
- Francis Guinan - Jack Biggs
- Dave Allen - Tom
- Reginald VelJohnson - Brother Heywood
- Holly Robinson Peete - Christina
- Kathy Bates - Kay
- Susan Sarandon - J.C. Small
- Joel Murray - Dr. Jeffries
- Eric Allan Kramer - Officer Seely
- Jamie Denbo - Officer Soltz
- Jessica Chaffin - Allison
- Wallace Langham - Robert
- Jack McGee - Officer Gronski
- Casey Washington - Ramirez
- Ava Gaudet - Raven
- Kiara Muhammad - Krystal
- Amy Farrington - Karen
- Juliette Goglia - Frannie DuVall
- David Trainer
- Stephen Prime
- Steve Prime
- Victor Gonzalez
- Jason Alexander
- Phill Lewis
- Steve Joe
- Rob DesHotel
- Alex Herschlag
- Mark Gross
- Julie Bean
- Bill Daly
- Chuck Lorre
Marianne Muellerleile interpreta a Connie en la serie.
William Sanderson interpreta a Dennis en la serie.
Susan Sarandon interpreta a J.C. Small en la serie.
Melissa McCarthy interpreta a Molly Flynn en la serie.
Billy Gardell hace el papel de Mike Biggs.
Reno Wilson hace el papel de Carl McMillan.
Swoosie Kurtz hace el papel de Joyce Flynn.
Katy Mixon hace el papel de Victoria Flynn.
Louis Mustillo hace el papel de Vincent Moranto.
Capítulo disponible en las siguientes plataformas:
