- Shaun Johnston - Roy Cates
- Belinda Metz - Anne Cates
- Sarah Lind - Dee Sampson
- Daryl Shuttleworth - Ted Sampson
- Heath Lamberts - P.T. Barnum
- Katharine Isabelle - Annie Sullivan
- Emily Perkins - Mary Shelley
- Peter Outerbridge - Dr. Milton Bradshaw
- Elliott Gould - Albert Einstein
- Len Cariou - Alexander Graham Bell
- Lisa Jakub - Joan of Arc
- Wendell Smith - McSween
- Paul Daniel Wood - Police Officer (as Paul Wood)
- Tom Cavanagh - Lewis Carroll (as Thomas Cavanagh)
- Saul Rubinek - Napoleon Bonaparte
- Michele Miller - Mother
- Simon MacCorkindale - Oscar Wilde
- Henry Czerny - Ludwig van Beethoven
- Patricia Casey - Dr. Preston
- Matt Frewer - Frederick Banting
- Adam J. Harrington - Sandy Mear (as Adam Harrington)
- Brian George - St. Nicholas
- Judy Norton - Ray Cates’ Girlfriend
- Michael Sarrazin - Edgar Allan Poe
- Sandra Caldwell - Harriet Tubman
- Brian Dooley - Principal
- Ellie Harvie - Cleopatra
- Marie Zydek - Alicia
- Karen LeBlanc - Gina Lester
Capítulo disponible en las siguientes plataformas:
