- Jessica Lundy - Sandra O'Bannon / Lisa Wolfe
- Wallace Langham - Alan
- Sarah Drew - Suzie Keener
- Tony Curran - Lucas Harvey
- Grant Shaud - Leo Krane
- Ellen Geer - Grandma Benoit
- Thomas Ian Nicholas - Greg Watt
- Anastasia Griffith - Samantha Emory
- Shane McRae - Eric Rogich
- Carlos Lacámara - Jorge Navarro
- Brian Kerwin - Nathan Bradley
- Molly Ringwald - Kathleen Walsh
- Martha Plimpton - Rosemary Widdick
- Amy Pietz - Nancy Covington
- Cecilia Suárez - Maria Vargas
- David Morse - Douglas Lydecker
- Khalil Kain - Malcolm Littleton
- Michelle Marsh - Secretary
- Rumer Willis - Bethany Simmons
- Treva Etienne - Man on Phone
- Reiley McClendon - Todd Gromada
- William Schallert - J. Donald Kessinger
- David Arquette - Michael 'Lucky' Benoit
- Gabriel Olds - Kent Henley
- Sara Botsford - Constance Madsen
- Remy Ryan Hernandez - Pablo's Wife
- Jennette McCurdy - Sara Crewson
- Jonathan Chase - Cowboy
- Tim Guinee - Sean Caffey
- Zoe Kazan - Izzy
- Robert Rusler - David Barrington
- Miguel Ferrer - Joey / Teddy Carmichael
- Charlie McDermott - Brandon Whitman
- Jorge-Luis Pallo - Armando
- Spencer Garrett - HR Executive
- James Van Der Beek - Dylan Hoyt
- Jasmine Jessica Anthony - Young Girl
- Tim Conlon - Walter Waller
- Octavia Spencer - Jurist
- Amber Barretto - College Girl
- Marcus Giamatti - Lance Pauling
- Kelly Overton - Robin Aaronson
- Joey King - Kelly Mackenzie age 8
- Kevin Corrigan - David Brewer
- Scott Holroyd - Michael Gilpin
- Tom Everett - Sponsor
- Hunter Brochu - Bobby Lechelle
- Camryn Grimes - Sharona
- Alan Ruck - Albert Bunford
- Todd Louiso - Troy Sanborn
- Holt McCallany - Nick Lewin
- Ryan Michelle Bathe - Claire Williams
- John Ortiz - Daniel Muñoz
- Richmond Arquette - David Saunders
- Andrew James Allen - Jeremy
- William Sadler - John Edgemont
- Chris Messina - Casey Edward Frank
- Jenny Mollen - Lydia Kyne
- Jake Richardson - Tyler Downey at High School
- Paul Blackthorne - Henry Stoller / Henry Stoller's Son
- Mimi Kennedy - Helen Fitzpatrick
- Adam Goldberg - Bruce Rossiter
- Aleksa Palladino - Lyla Gallagher / Geraldine Hanscombe
- William Allen Young - Wesley Judson
- Beth Grant - Librarian
- Mason Cotton - Ben Goldman
- Jodi Carlisle - Whitman's Secretary
- Yancey Arias - Alberto Torres
- Roger Aaron Brown - Evan Sabow
- Mark Steines - Host
- Lawrence Monoson - James Massey
- Noel Fisher - Jessie Andrews / Brian
- David Carradine - Jessica's Brother
- Aida Turturro - Bobbi Catalano
- Jay R. Ferguson - Tommy Lehane
- Maïté Schwartz - Janet
- Blythe Danner - Louise Leaming
- Vanessa Lengies - Zoey Lehman
- Brent Briscoe - Trent
- Deirdre Lovejoy - Dr. Messner
- Natalia Baron - Sally Greer
- Kevin Cooney - P.O.W.
- Annabelle Gurwitch - Rory Carmer
- Nick Price - Older Boy
- Casey Biggs - Ken Androsky
- Enuka Okuma - Julie Skahan
- Elizabeth Hendrickson - Mindy
- Madison Mason - Lawyer
- Ryan Hurst - Michael Benoit
- Joe Manganiello - Angelo Filipelli
- John DeMita - Ted Lowry
- Brian Hallisay - Sean Covey
- Elizabeth Dennehy - Hasting's Boss
- Geoff Pierson - Sam Winters
- Diane Venora - Sarah Jane Levitt
- Balthazar Getty - Christopher Dennis Sipes
- Daniel Bess - Young Man
- Alexandra Breckenridge - Isabel Galvan
- Blake Robbins - Trooper
- Rachel Miner - Emilia Purcell
- Edoardo Ballerini - Sam Elkin
- Emma Stone - Cynthia McCallister
- Katy Selverstone - Marilyn Downey
- Molly Hagan - ER Doctor
- Sierra McCormick - Adolescent Allison
- Rob Benedict - Passenger
- Robert Joy - Kenneth Holloway
- Gina Hecht - Dr. Andrews
- J.C. MacKenzie - Dan Taper
- Jenette Goldstein - Mrs. Pinsley
- Jon Polito - Vincent Discala
- Jonno Roberts - Don Burnes
- Charlayne Woodard - Dr. Richards
- Emiliano Torres - Mr. Vincent
- Peter Wingfield - Sean Redburn
- Del Zamora - Maintenance Man
- Rick Worthy - The Regal Man
- Kate Levering - Elizabeth Randall
- Nestor Serrano - Hector Alvarez
- Tania Raymonde - Taylor Greene
- Phil Reeves - Doctor
- Michael Raymond-James - Travis McQueen
- Reynaldo Rosales - Mr. Wallaby
- Anjul Nigam - Doctor
- Perrey Reeves - Karen Herzfeld
- Thom Hoffman - Boy
- Kate Burton - Bonnie Barrister
- Paul Adelstein - Craig
- Josh Holt - Young Man in Diner
- Chloe Webb - Margaret Folsom
- Matt Letscher - Dr. Erik Westphal
- Reed Diamond - Jared Swanstrom
- Frances Fisher - Abigail Marsh
- Peri Gilpin - Diane Benoit
- Xander Berkeley - Mitchell Slocombe
- Amanda Detmer - Sarah
- Erin Chambers - Julie Snowden
- Michael Robert Brandon - Other Man
- Robert Curtis Brown - Dr. Sandborn
- Daniella Alonso - Elizabeth Torres
- Nancy Travis - Laura Swenson
- Alex Fernandez - Martin Gibbons
- James Eckhouse - Dr. Gromada
- Silas Weir Mitchell - Deranged Husband
- Paul Perri - Henry Rykoff
- Cameron Dye - Jimmy Fleming
- Oded Fehr - Thomas Statler
- Fisher Stevens - Neal Greybridge
- James Urbaniak - Mr. Enright
- Amy Hill - Receptionist
- Jaime Ray Newman - Angela Saunders / Jade
- John Vickery - Gerald Prosser
- Lily Rabe - Joanna Wheeler
- Bret Loehr - Owen Kearns
- Jessy Schram - Young Allison
- Vondie Curtis-Hall - Scanlon's Friend
- Bruce McGill - Jerry Carlisle
- Steven Culp - Darren Swenson
- Zach Grenier - Leonard Cardwell
- Jeffrey Tambor - Todd Emory / Allison Dubois
- Randy Oglesby - Parole Board Chairperson
- Summer Altice - Magazine Girl
- Eve Gordon - Patty Staley
- Maura Soden - Teacher
- Marisa Coughlan - Gabrielle
- Sam Trammell - Dr. Brian Seward
- Enzo Rossi - Arlo Slocombe
- Harley Graham - Lucy Carlow
- Rick Gonzalez - Juan Espinosa
- Tyrees Allen - Capt. Jackson
- Howie Mandel - Howie Mandel
- Pruitt Taylor Vince - Peter Winant
- Taylor Nichols - Paul Downey
- Michael Gross - Peter Barrister
- Neil Vipond - Old Henry Stoller
- George Newbern - Thomas O'Bannon
- Fredric Lehne - David Delaney
- Zilah Mendoza - Admitting Nurse
- Eric Stoltz - Sonny Troyer
- Allyce Beasley - Ruth Boddicker
- Eric Pierpoint - Chief Parker
- Marc Gomes - Doctor
- Ebon Moss-Bachrach - Simon Burwell
- Colby French - David Chadway
- Kay Panabaker - Elisha
- Suzanne Davis - Cristin Morehouse
- Lizette Carrión - Cashier
- Bubba Lewis - Connor Widomski
- Matt Cohen - Ryan Haas
- Joey Slotnick - Brett Carter
- Melanie Paxson - Miss Colletto
- Dariush Kashani - Doctor
- Alexandra Krosney - Keelin McKinney
- Arjay Smith - Young Evan Sabow
- Gina Philips - Colleen Fitzpatrick Barlow
- Suzanne Santo - Christine Lovell
- Luna Lauren Velez - Elena Cabrera
- Joshua Malina - Tim Carmer
- Tracy Pollan - Caitlyn Lynch
- Evan Parke - Owen Butler
- Mozhan Marnò - Rachel
- Jamil Walker Smith - Raymond Vargas
- Matthew Del Negro - Michael Skahan
- Bellamy Young - Kate Emery
- Ben Weber - Morgan Turley
- Barbara Tarbuck - Carol Waller Smith
- Geoffrey Owens - Unemployment Evaluator
- Marianne Muellerleile - Bartender
- Natasha Gregson Wagner - Beverly Waller
- Tim Hopper - Michael Levitt
- Vivian Bang - Nurse
- Amy Landecker - Lindsay Burke
- Sarah Hagan - Young Suzannah
- James Frain - Calley
- Will McCormack - William Gerwin
- Andy Milder - Mr. Beauchamp
- Johnny Pacar - Intoxicated Boy
- Don Harvey - Darrell Yellen
- Gregory Itzin - Senator Jed Garrity
- Arliss Howard - Kenneth Push
- Sarah Lilly - Olga Z
- Alejandro Patiño - Driver
- Abby Brammell - Dana Carlow
- Robert Beltran - Father Armando Avilar
- Max Casella - Joel Tiernan
- Kevin Alejandro - Jason Morrow
- Natalie Zea - Sophie Cullen
- Mark Harelik - Elliott Davis
- Romy Rosemont - Jury Consultant
- Kyle Gallner - Young Stephen
- Dennis Boutsikaris - Dr. Anthony Woodel
- Pablo Schreiber - Jeremy Kiernan
- Brad Greenquist - Michael Williams
- Ronny Cox - Mr. Hammond
- Diedrich Bader - Fred Rovick
- Michael Laskin - Dr. Bondi
- Morena Baccarin - Brooke Hoyt
- Lee Garlington - Marion Wheeler
- Gretchen Egolf - Mary Stacey
- John Shea - David Morrow
- Grace Zabriskie - Connie Buckley
- Bill Tangradi - Dancing Man
- Danielle Panabaker - Summer Lowry
- Rosanna Arquette - Michelle Todd
- Khary Payton - Mr. Bronson
- Dempsey Pappion - Mr. James
- James Patrick Stuart - Stephen Garner
- Carol Potter - Secretary
- Ben Feldman - Justin Lydecker
- Alicia Coppola - Ms. Ballou / Mrs. Church
- Lawrence Pressman - Therapist
- John Getz - Stuart McCallister
- Jim True-Frost - Stephen Campbell
- Matt Barr - 17-Year Old Boy
- Jess Weixler - Mandy Sutton
- Johnathan McClain - Ted
- Steven Flynn - Peter Connolly
- April Grace - Balinda Alexander
- Bridget White - Rebecca Lowry
- Jaimi Paige - Waitress
- Andi Eystad - Bella Kayne
- Vicki Davis - Young Katie
- Ramón Franco - Store Manager
- Cas Anvar - Dr. McGraff
- Betty Gilpin - Kim Clement
- Michael Kopelow - Counterman
- Tom Verica - Aaron Carver
- James T. Callahan - Jury Foreman
- Michael Cavanaugh - Defense Attorney
- Shawn Doyle - Brad Auerbach
- Megan Henderson - Reporter
- Jan Hoag - Middle Aged Woman
- Rolando Boyce - Randy Littleton
- Neve Campbell - Debra
- Neve Campbell - P.D. McCall
- Kyle Colerider-Krugh - Mr. Marcotullio
- Aaron Refvem - Finn Miller
- Rami Malek - Timothy Kercher
- Katie Kreisler - Melinda Bell
- Rizwan Manji - Rental Agent
- Jennifer Lawrence - Young Allison
- Jennifer Lawrence - Claire Chase
- Emily Alyn Lind - Six Year Old Girl
- Eric Unger - Son
- Asher Book - Wyatt Forrester
- Donna Bullock - Therapist
- Morann Peri - Lorena Vasques
- Cody Longo - Gavin Coley
- Ray Porter - Putt Putt Golf Man
- Jaden Sorensen - Little Boy
- Jill Remez - Crime Tech
- Thomas Jane - Clay Bicks
- Matt Malloy - Alan Gardener
- Ryan Self - Waiter
- Tom Titone - Doctor
- Leslie Ishii - Bartender
- Joe Hart - Middle-Aged Man
- Sarah Knowlton - Doctor
- Andy Pessoa - Boy
- Jessica Lancaster - Other Woman
- Kasey Mahaffy - Waiter
- K.T. Thangavelu - Nurse Dunbar
- Don Luce - Man in Bank Line
- Atom Gorelick - High School Kid
- Karen Maxwell - Young Woman
- Joshua Minnick - Young Man
- Sky Soleil - Bank Robber
- Lavetta Cannon - Hospital Nurse
- Christina Pickles - Mrs. Walker
- Shanna Collins - Amanda
- Michael Fairman - Frontier Doctor
- Michael Shamus Wiles - Sheriff
- Christa B. Allen - Maura Walker
- Josie Loren - Michelle Vega
- Ann Walker - Prospector's Wife
- Ryan Judd - Deputy
- James A. Watson, Jr - Public Defender
- Kathleen Robertson - Kathy / Diana Marvin
- Blair Hickey - Salesman
- Damara Reilly - Meredith Johnson
- Ellie Gerber - Allison at age 16
- Jordan Moser - Bobby Page
- Jon David Casey - Warren Bell
- Wilson Jermaine Heredia - Richard Gomez
- Caroline Macey - Diane Colquitt
- Jordan Baker - Patty Chase
- Joel Anderson - Ben Radley
- Susan Grace - Teacher
- Michael Bolten - Teenage Boy
- Tyler Foden - Teenage Boy
- Ruth Williamson - Mrs. Rykoff
- Christian Alexander - Young Casey
- Albert Malafronte - Lawyer
- Ryan Shively - Park Ranger
- Kathy Lamkin - Gladys Discala
- Nicholas Hormann - Franklin Gates
- Bryce Robinson - Oliver Levitt
- Tad Griffith - Heavyset Man
- William Charlton - Sergei Timur
- A. Russell Andrews - Mike
- Rebecca Wisocky - Janice
- Link Baker - Security Guard
- Jason Kaufman - EMT
- Akiko Morison - Orderly
- Patrick Stinson - News Anchor
- Ana Mercedes - Dora
- Donna Pieroni - Nurse
- Christopher Fairbanks - Driver
- Charlie Hofheimer - David Channing
- Jessica Lindsey - Older Ariel Dubois
- Nancy Bell - Saleswoman
- Traber Burns - Landlord
- Will Beinbrink - Impound Officer
- Christopher Shaw - NA Attendee
- Lynette DuPree - NA Attendee
- Josh Wingate - NA Attendee
- Rueben Gonzáles - NA Attendee
- Annie Campbell - Nurse
- Joshua Rush - Tanner Campbel
- Joshua Rush - Boy in Banana Costume
- Kirsten Potter - Woman
- Steve Kazee - Michael Barlow
- Peter Birkenhead - Lie Detector Administrator
- Saundra McClain - Nurse
- Ramón De Ocampo - Aaron
- Kate Blumberg - Gail Rossiter
- Larry Miller - Dylan Kravitz
- Susan Kelechi Watson - Subordinate
- Takayo Fischer - Asian Woman
- Kevin Symons - Businessman
- Cindy Pickett - Tanya King
- Warren Kole - Wesley King
- Shashawnee Hall - Principal Phillips
- Deborah Offner - Mrs. Ueberschaer
- Christopher McDonald - Gregory King
- Dru Mouser - Monica
- Andy Mackenzie - Henry Alonzo
- Robert Neary - Peter Barbera
- Lesley Boone - Justine Godrich
- Lesley Boone - Sondra Banister
- Elisabeth Moss - Jennie / Haley Heffernan
- Kimberly Scott - Coroner
- Adrian Sparks - Manager
- Kate McGregor-Stewart - Landlady
- Rubén Garfias - Pawn Shop Owner
- Kerris Dorsey - Young Jennie
- Dakin Matthews - Arthur Brock
- David Aaron Baker - Dr. Myers
- Katie MacNichol - Natalie Paxton
- Aaron McPherson - Bailiff
- Dagmar Midcap - Reporter
- Lydia Blanco Garza - Housekeeper
- Dre Slaman - Waitress
- Jason Priestley - Walter Paxton
- Arye Gross - Cooper Conroy
- Amy Price-Francis - Pamela Franklin
- Gerry Becker - Marcus Canty
- Rayne Guest - Cheryl Ann Potts
- Colette Kilroy - Elizabeth
- Joe Leroy Reynolds - Cassette Recorder Man
- Nick Toren - Camera Man
- Marcus Chait - Mr. Goldman
- Julie Dretzin - Mrs. Goldman
- Jane Lanier - Female Campaign Official
- Mark Hutter - Male Campaign Official
- Zoë Hall - Brooke Green
- Rebecca Mozo - Teacher
- Martin Pierron - Mr. Kay
- Larry Clarke - Officer Ben Talmadge
- T'Shaun Barrett - Uniform Cop
- T'Shaun Barrett - Male Voice
- Freddie Smith - Senior Boy
- Kathleen Early - Melissa Barrister
- Scott MacArthur - Anton
- Lynne Taylor - Newscaster
- Craig Tsuyumine - Newscaster
- Erich Anderson - Cyrus
- François Chau - Doctor
- Alexis Raich - Nicole Swenson
- Paige Howard - Myra Edgemont
- Lauren Rigau - Chloe Edgemont
- James Immekus - Michael Rhodes
- Jacob Fishel - Young Jed Garrity
- Sean Wing - Young Gordon LaRoche
- Barry Cullison - P.O.W.
- Laura Eichhorn - Hostess
- Bryan T. Donovan - Political Consultant
- John Sloman - Fire Brigade Captain
- Steven Owsley - Principal Reed
- Emily Wing - Ms. McGreal
- Robert Maxhimer - Man Behind Counter
- Paul Fitzgerald - Graham Stacey
- John Cothran - Judge Brock
- Anne Gee Byrd - Mrs. Fogarty
- Ryan Cutrona - Reginald Smythe
- Bill Heck - David Draper
- Jennifer Riker - Loan Officer
- Lisa B. Tharps - Nurse
- Jude Ciccolella - Richard Madsen
- Edward Finlay - Actor
- Peter Porte - Fourth Man
- Todd Weeks - Ben Salzberg
- Zak Lee - Julian Pierce
- Greg Thirloway - Husband
- Kristin Proctor - Wife
- Karole Foreman - Receptionist
- Julieta Ortiz - Maid
- JD Cullum - Optometrist
- Serena Reeder - Ms. Hastings
- Kevin Cristaldi - Voyeur
- Ashley Hinson - Woman
- Craig Bonacorsi - Nick
- Leslie Cohen - Female Voice
- Jon Fleming - Suspect
- Jonathan Adams - Curtis Lambert
- Judith Moreland - Physical Therapist
- William Brent - Young Joey / Teddy Carmichael
- Kristen Bush - Bartender
- Tim Monsion - Principal
- Kelly Preston - Meghan Doyle
- Noah Bean - Charles Winters
- Mireille Enos - Kelly Winters
- John Prosky - Tom Van Dyke
- Erin Cottrell - Madeline McKenzie
- Dean Norris - Paul Scanlon
- Dean Norris - Detective Rickey
- Erin C. Buckley - Assistant
- John Hawkinson - Attorney
- Pamela Gray - Mrs. Tharp
- Emily Bergl - Victoria
- Lucas Till - Adam Mankowitz
- James M. Connor - Patrick Davidson
- Erica Piccininni - Stacey Bonner
- Taylor Geare - Little Girl
- Luis Carazo - Diego Molino
- Byron Quiros - Man
- Stephanie Patton - Blonde Teenager
- Peggy Goss - Mother
- Angela Bullock - Psychiatrist
- Mark Colson - Balding Man
- Rich Skinner - Obese Man
- Cade Canon Ball - Young Boy
- Georgia Hatzis - Meredith Burnes
- Stephen Mendillo - James Leaming
- Heather Mazur - Clare Burnes
- Darcy Rose Byrnes - Phoebe Burnes
- Seth Isler - Doctor
- Abdul-Khaliq Murtadha - Foreman
- Ryan Caltagirone - Young Man
- Aly Mawji - Waiter
- David Warshofsky - Russell Burgess
- Matt Kaminsky - Mr. Walsh
- Jim Cantafio - Mr. Donlin
- Kurtwood Smith - Edward Cooper
- John Ales - Hal Munzell
- Eddie Driscoll - Adam Dietz
- Maura M. Knowles - Rachel Stetson
- Roy Abramsohn - Douglas Reilly
- Marc Jablon - Paul Burke
- Kenneth Meseroll - Lawyer
- Matt Champagne - Bradley Atkins
- Mike Peebler - Zachary Giltner
- Dahlia Salem - Harmony Fletcher
- Bryan Callen - Ryan
- Scott Lawrence - Doctor
- David Barry Gray - Nathan Hunsecker
- Ginifer King - Jessamyn
- Kevin Brief - Klog King Plumber
- Jeremiah Birkett - Doctor
- Elsie Fisher - Young Bridgette
- Andrew Thacher - Jeremy Crane
- Regi Davis - Passer-By
- Paul Bartholomew - Teacher
- Andrew Rothenberg - Kevin Flynn
- Diana Yekinni - Jane Doe
- Kedren Werner - Nurse
- Jessica McKee - Trisha Daniels
- Stuart McLean - Donald / Smiley-Face
- Brooke Mackenzie - Crying Girl
- Rod McLachlan - Bill Whitaker (voice)
- Jennifer Carta - Margaret
- Derek Magyar - Garrett Russell
- Susan Angelo - Registration Nurse
- Joanna Strapp - Marie's Teacher
- Karen Pittman - Nurse
- Casey Williams - Nurse
- Brianna Borden - Girl in Drumstick Costume
- Anjelica Huston - Cynthia Keener
- Ted Garcia - Reporter #3
- Ted Garcia - Newscaster
- Ted Garcia - On-the-Scene Newsman
- Ned Schmidtke - Terry Cavanaugh
- Willie Garson - Alan Hitchens
- Ron Marasco - Dr. Atwell
- Starletta DuPois - Woman
- Bee-Be Smith - Nurse
- Catherine O'Connor - Teller
- José Zúñiga - Oswaldo Castillo
- Efrain Figueroa - Hector Cruz
- Vivis - Maria Lima
- Joe Stevens - Lieutenant Gleason
- Joe Stevens - Sergeant
- Chris Bresky - Pizza Delivery Guy
- Toni Torres - Mrs. Ruiz
- Ben Bode - Drew Campbel
- Chris McGarry - Kevin Charles
- Mia Barron - Gretchen Mitchell
- Eddie Jemison - Willem Wittmar
- Reedy Gibbs - Nurse
- Ameenah Kaplan - Nurse
- Mimi Lieber - Speech Therapist
- Marc Aden Gray - Evan Boyce
- Kamala Lopez - Walter Paxton's Attorney
- Kamala Lopez - Miss Romney
- Kamala Lopez - Paxton's Attorney
- Ric Sarabia - John David Boatner
- Jason Paul Field - Lineup Man
- Shane Woodson - Lineup Man
- Christopher Wiehl - Scott Carlow
- Gary Wolf - Music Store Clerk
- François Giroday - Waiter
- Kofi Natei - Police Officer
- Walter Addison - Carl Catalano
- John Lee Ames - Edgar Kripke
- Shea Whigham - Patrick Wilkes
- Hayley McFarland - Jamie Portman
- Emily Swallow - Erica Duvall
- Yvette Cruise - Maid
- Robert Christopher Riley - Police Officer
- Annamarie Kenoyer - Ashley Whitaker
- Faith Prince - Lauren Portman
- Franc Ross - Jesse Reeder
- Nija Okoro - Bank Teller
- Adam Monley - Young Man
- Luis Augusto Figueroa - Latino Man
- Pilar Holland - Latina Woman
- Matt Prokop - Kyle 'K.C.' Covington
- John Ellison Conlee - Lloyd Darby
- Lorin McCraley - Earl Sanderson
- Clarinda Ross - Anna
- Reynaldo Gallegos - Cesar
- James Leo Ryan - Levar Cole
- Andrew Borba - Doctor
- Keith Contreras - Young Executive
- Adam J. Smith - Young Executive
- Gregory Sims - Mitchell Lomis
- Kent Shocknek - Newscaster
- Alexie Gilmore - Gretchen Morgan
- Alejandro Furth - Morgue Attendant
- Olivia Sandoval - Arianna Devalos
- Michael Sollenberger - Doctor
- Carlos Sanz - Man in Suit
- Erin Raftery - Deanna Whalen
- Tobias Segal - Chad Lowry
- Michole Briana White - Dr. Cheryl Kung
- Britt Flatmo - Young Summer Lowry
- Ellen Hollman - Mallory Kessinger
- Ian Reed Kesler - Mr. Teefers
- Connor Rosen - Jeb Behrends
- Johnny Chavez - Bailiff
- Laura Prepon - Kira Hudack
- Derek Phillips - Sean Riley
- Daniel Booko - Crew Cut
- Shaun Baker - Paramedic
- Lysander Abadia - X-Ray Tech
- Ana Mackenzie - Kate Hatton
- Geoffrey Arend - Andy Seward
- Stephanie Pearson - Julie Pinsley
- John Forest - John 'DJ' Dunham
- Dwight Ewell - Florist
- Emerson Brooks - Police Officer
- Tom Beyer - Officiant
- Douglas Dickerman - Grown Man
- Brian Avers - Brian Fondran
- Mike Hagerty - Large Man
- Will Peltz - Nervous Young Man
- Gabriel Morales - Adolescent Devalos
- Erik Smith - Nicky
- Skoti Collins - Mr. Martin Prescot
- Joel David Moore - Keith Bruning
- Vanessa Marano - Jennifer Whitten
- David Dayan Fisher - Jonathan Thigpen
- Cornell Womack - Colonel Mark Reidy
- Matt Biedel - Highway Patrolman
- Leslie Thurston - Nurse
- Jonathan Silverman - Matt Mulhearn
- Melinda McGraw - Sondra Hahn-Barker
- Raphael Sbarge - Josh Berryman
- Annika Peterson - Amy Mulhearn
- Ryun Yu - Henry
- Greg Germann - Dr. Alan Hahn
- Michael Rady - Liam McManus
- Jenna Gavigan - Mrs. Lisa Kerrigan
- Myk Watford - Daniel Kerrigan
- Taylor Groothuis - 5-Year-Old Anna
- Shannon Welles - Octogenarian Ariel
- Tony Elias - Police Officer
- Alexandra Chando - Melissa Treynet
- Pat Skipper - Bill Ruettiger
- Sam Lloyd - Danny Watson
- Roma Maffia - Victoria Gossett
- Teri Polo - Mary-Louise Graff
- Mark Sheppard - Charles Walker
- Brett Davern - Ryan Graff
- Margaret Colin - Kelly Shuler
- John Linton - Clarence Denton
- Christopher Duva - DJ
- Gina St. John - Reporter #2
- Gina St. John - Newscaster
- Peggy Dunne - Engineer
- Peggy Dunne - Shopper
- Christina Scherer - Shannon Mitchell
- Dylan Minnette - Cameron
- Carlos Jacott - Gary Durant
- Tony Sirico - Tony
- Michael Hyatt - Cameron's Attorney
- Tracey Walter - Walter Durant
- Royana Black - Mrs. Hudson
- Tom Schmid - Cameron's Dad
- Michael Patrick McGill - City Worker
- Jessica Hecht - Judy Bennette
- Lana Parrilla - Lydia Halstrom
- Michael Gladis - Dave Anderson
- Tony Hale - Gil Bureli
- Elizabeth Roberts - Melinda Sully
- Frank Cappello - Waiter
- Edward Padilla - Clerk
- Ronnie Gene Blevins - Biker
- Brett Collier - Meter Attendant
- Frank Whaley - Gabe Helling
- Matt McTighe - Mr. Scanlon
- Angela Pierce - Samantha Coakley
- Seri DeYoung - Rebecca Coakley
- Griffin Cleveland - Young Lee Scanlon
- Austin Trace - Young Paul Scanlon
- Tom Wopat - Sheriff Gillery
- Elizabeth Rice - Caroline Krueger
- Vedette Lim - Paramedic
- Patrick Zeller - Officer
- Jarod Einsohn - Deputy
- Antonio D. Charity - Deputy
- Gregg Henry - Coach Swanson
- Katherine Sigismund - Coach Amy Gabler
- Matthew Glave - Dr. Heath Timlin
- Marc Vann - Wayne Lundgren
- Stan Egi - Surgeon
- Don Fischer - Josh Whitman
- Teri Reeves - Monica Janeway
- Candice Azzara - Elderly Woman
- Mary Garripoli - Mrs. Lundgren
- Clancy Brown - Rob Walcott
- David Burke - Gavin Finch
- Stoney Westmoreland - Russ O'Toole
- Angela Paton - Mrs. Halstead
- Jennifer Chang - Secretary
- Jack Harding - Goateed Man
- Caroline Kinsolving - History Teacher
- Judy Reyes - Jane Livingston
- Rena Sofer - Dr. Natalie Salem
- Brian Schwary - Copy Attendant
- Brian Schwary - Young Man
- Brian Schwary - Robert Edward Lowell
- Mark Webber - Blond Man / Man in Fireproof Suit
- Jesse James Youngblood - Navajo / Bank Robber
- Zahn McClarnon - Alex Keeswood / Driver
- Stevens Gaston - Merchant
- Jason Beghe - Frank Davenport
- Roxanne Hart - Lily Devalos
- Suzanne Cryer - Joanna Spencer
- Rob Mayes - Fireman
- Carlos Gómez - Benito Velez
- Samantha Droke - Charlotte Spencer
- Benjamin Byron Davis - Aaron Foley
- Bernardo de Paula - Wilfredo Soto
- Ross Philips - Man
- Bill Seward - Reporter #4
- Brian Howe - John Claybourne
- Sterling K. Brown - Todd Gillis
- Max Baker - Dale Oleck
- Abbie Cobb - Stacy McKee
- Laura San Giacomo - Susannah Collings
- Mitch Pileggi - Dan Burroughs
- Ed Francis Martin - CEO
- Melissa Bickerton - ND Neighbor
- Tyler Champagne - Young Boy
- Raúl Esparza - David Ostrowski
- Bruce Gray - Joe's Dad
- H. Richard Greene - Sam Diller
- Matthew Arkin - Doctor Chapman
- Aaron Hendry - Jerry Thornton
- Logan Lipton - Tom
- Thomas Blake Jr. - Bad Cell
- Lisa Ross - Well-Dressed Woman
- Jayne Taini - Heavyset Woman
- Ron Orbach - Ken Corrigan
- Lee Reherman - Jason Bumgarner
- John Glover - Carson Churchill
- Matt McKenzie - Managerial Type
- Ruby Lewis - Female Victim
- Christian Camargo - Jeremy Haas
- Nicole DuPort - Elena Haas
- Jillian Armenante - Veronica Tate
- Amir Arison - Harold Clark
- Andy Umberger - Principal Brand
- Linda Callahan - Dr. Tramble
- Bellina Logan - Miss Alpert
- Enrique Murciano - Luis Amenabar
- Roger Bart - Dennis Caruso
- Sasha Pieterse - 14-Year Old Marie
- Lily Knight - Judge Malone
- Charlie Koznick - David
- Scott Alan Smith - Byron Knox
- Jacob Vargas - Eduardo Garcia
- J. Paul Boehmer - Attorney
- Geno Monteiro - Bailiff
- Arianna Ortiz - Rest Home Worker
- Frank Wood - Crazed Man
- Bruce Nozick - Attorney
- Terry Woodberry - Texas Prison Guard
- John Paxton - Older Man
- Scott Rabinowitz - Raleigh
- Ken Kerman - Arizona Prison Guard
- Dan Romero - Announcer
- Lorenzo Callender - Pablo
- Frank Alvarez - Martinez
- John Mese - Ivan Kinetko
- Aisha Hinds - Maxine Harris
- Sofia Karstens - Rene
- Howard S. Miller - Defense Attorney
- Rebecca Metz - Diane
- Anna Maganini - Newswoman
- Reed Frerichs - Defendant
- Bruno Oliver - Waiter
- Jon Sklaroff - Mr. Rondell
- Paul Schackman - Aerospace Engineer
- Sam Vance - Officer
- Brandon Keener - Tim
- Phe Caplan - Donna
- Pia Artesona - Crying Woman
- Wayne King - Detective Wolfe
- Anahi Bustillos - Witness
- Elizabeth Payne - Teacher
- Nicole Pano - D.A. Assistant
- Margo Martindale - Catherine
- Robert Blanche - Robert Pulaski
- Lily Rains - Young Woman
- Catherine Wadkins - Young Woman
- Maria Quiban - Reporter
- Rachel Kimsey - Older Sharona
- Vincent Duvall - Officer
- Scott Klace - Lawyer
- Begonya Plaza - Medical Examiner
- Ariana Thomas - Volunteer
- Gus Lynch - Forest Ranger
- Joe Chrest - Henry Yellen
- Nelson Mashita - Clerk
- Jake Dinwiddie - Boy
- Randy Mulkey - Ranger
- Randy Mulkey - Texas Ranger
- Lisa Lackey - Kamala
- Michael Mantell - Nyles
- Caryn West - Mary Buckley
- Romeo Rene Fabian - Friend
- Phil Abrams - Director
- Kerry Leigh Michaels - Aide
- Christopher Michael - Guard
- Neal Matarazzo - Interrogating Detective
- Neal Matarazzo - Homicide Detective
- Janet Rotblatt - Old Woman
- Gino Montesinos - Reynaldo Cerrera
- Jaime Gomez - Pablo
- Faline England - Sarah / Melissa
- Dane Northcutt - Patrolman
- Roberto Montesinos - Nondescript Man
- Hector Atreyu Ruiz - Trunk Man
- Craig Gellis - Needle Man
- Diane Gaidry - Nurse
- Adria Dawn - Bitten Woman
- Jordan Garrett - Sean Bertoni
- Bobby Coleman - 7 Year-Old Boy
- Paul McCarthy-Boyington - Boyfriend
- Louis Iacoviello - Policeman
- Frank Ertl - Warden
- Robb Reesman - Guard
- Seth T. Walker - Detective
- Seth T. Walker - Forensic Tech
- Michael Bentt - Guard
- Jess King - Guard
- Fay Masterson - Passenger
- Chad Lowe - David Call
- Michael Crider - New Pilot
- Elliott Grey - Co-Pilot
- John Hartmann - Forensics Specialist
- Patrick Robert Smith - Delivery Man
- Nicholas Logan - Eddie
- Kathy Baker - Marjorie Dubois
- Samantha Quan - Deborah
- Paul Norwood - Puzzled Man
- John Montana - Rickey's Partner
- Brent Jennings - Wayne
- Todd Malta - Admirer
- Nealla Gordon - Elisha's Mother
- Lenora May - Mother
- Saida Pagan - Morning News Anchor
- Saida Pagan - TV Reporter
- Saida Pagan - Newscaster
- Annabelle Milne - Friend
- Annabelle Milne - Cathy Croshaw
- Sumalee Montano - Nurse
- Roz Witt - Nurse
- Michele Harrell - Nurse
- John O'Brien - Hotel Clerk
- Lyn Alicia Henderson - Nurse
- Christopher Hoffman - Photographer
- Kelly McNair - Young Woman
- Zoe Simpson - Woman in Hall
- Jessica Stier - Young Woman
- Florence Regina - Ward Nurse
- Zack Duhame - Officer / Phantom
- Ryan de Quintal - Upset Fan
- David Barrera - Fr. Santiago
- Oriana Oppice - Isabel Navarro
- Elizabeth Gudenrath - Student
- Sam Anderson - Eliot Peterson
- Carson Elrod - Roger
- Warren Sweeney - Security Guard
- Derick Alexander - Orderly
- Ronald William Lawrence - Orderly
- Steven M. Gagnon - Cop
- Loren Lazerine - Cop
- Ron Perkins - Bank Manager
- Ryan Carlberg - 21-Year Old
- Logan Grove - Justin Church
- Ciro Suarez - Examiner
- Del Monroe - Old Man
- Conor O'Farrell - Larry Watt
- Hayes MacArthur - Randy Pilgrim
- Hari Dhillon - Chand Sooran
- Troy Blendell - Elliott
- Jacory Gums - Damon Hodges
- Jeanette Brox - Amanda Staley
- Reena Dutt - Keaton
- Alan Woolf - Judge
- Troy A. Cephers - Fireman
- Mary Strong - Reporter
- Mary Strong - Sports Reporter
- Vitta Quinn - TV Reporter
- John Wesley - Judge
- Elena Fabri - Jessica Garner
- John Harnagel - Middle Aged Man
- John Rubens - Officer
- Walker Howard - Clyde Morton
- Jeff Campbell - Steve Herzfeld
- Monnae Michaell - Clyde's Mother
- Harry Groener - Joe's Boss
- Kyle Bornheimer - Waiter
- Susan Santiago - Inez Avila / Gloria
- Ian Patrick Williams - Professor
- Suki Kaiser - Nadine Massey
- Paige Hurd - Ashley
- Sydney Walsh - Medical Examiner
- Rachael C. Smith - Kathy Summers
- Lisa Jay - Patricia Gilmartin
- Benjamin Mouton - Stickman
- Cheyenne Wilbur - Super
- Norma Michaels - Mrs. Jorgensen
- Dyllan Christopher - Todd's Friend
- Ian Barford - Butcher
- Felice Heather Monteith - Librarian
- Di Quon - Babysitter
- Gina Marie Fields - Uniformed Officer
- Joseph Buttler - Teacher
- Andrew Lewis Caldwell - Student
- Roma Chugani - Dr. Sooran
- Haynes Brooke - Faux Joe
- Channing Nichols - Faux Ariel
- Willard E. Pugh - Security Guard
- Jensen Atwood - Pimp
- Naja Hill - Black Woman
- Meagan Moore - Blond Woman
- Stacie Rippy - Redheaded Woman
- Adam Kulbersh - Dr. Kelsch
- David Haydn-Jones - Mr. Morehouse
- Cajardo Lindsey - Reporter
- Jon Carlo Alvarez - Worker
- Adam Shapiro - Worker
- Rebecca Gayheart - Jessica Delaney
- Michaela Watkins - Clerk
- Salvator Xuereb - Bobby
- Jayden Lund - Bartender
- Bunnie Rivera - Maid
- Jim Holmes - Caller
- Matt Winston - Mr. Cathcart
- Holliston Coleman - Hannah
- Jeff Corbett - 2005
- Jay Huguley - Larry Greene
- Jamison Yang - Edrick
- Wayne Grace - Christopher Russo
- Rachel Vacca - Amanda Crane
- Tahmus Rounds - Prisoner
- Vernard 'Bone' Hampton - Prisoner
- Frank Gallegos - Prisoner
- Kelsey Grammer - Bob Sherman / Angel of Death
- Yareli Arizmendi - Coroner
- David James Elliott - Johnny Dunham
- Darlena Tejeiro - Imelda
- Christina Souza - Bettina
- Moira Price - Judge
- David Jahn - Associate
- Jack Walsh - Scanlon's Dad
- Jacob Cooney
- Javier Grillo-Marxuach
- Glenn Gordon Caron
- Kelsey Grammer
- Laurie Seidman
Don Harvey interpreta a Darrell Yellen en la serie.
Angela Paton interpreta a Mrs. Halstead en la serie.
Willie Garson interpreta a Alan Hitchens en la serie.
Ronny Cox hace el papel de Mr. Hammond.
Lily Rabe interpreta a Joanna Wheeler en la serie.
Marianne Muellerleile interpreta a Bartender en la serie.
David Morse hace el papel de Douglas Lydecker.
Kurtwood Smith interpreta a F.B.I. Agent Edward Cooper en la serie.
Jeffrey Tambor interpreta a Todd Emory / Allison Dubois en la serie.
Taylor Nichols interpreta a Paul Downey en la serie.
Capítulo disponible en las siguientes plataformas:
