- Tyler Ritter - US Attorney John Brownlee
- Ana Cruz Kayne - Brianna Ortiz
- John Ales - Dr. Gregory Fitzgibbons
- Carolina Bartczak - Lily Kryger
- Ron Lea - Bill Havens
- Kyle Gatehouse - Riggs
- Daniel Kash - Stanley
- Stuart Hughes - Tony
- Yasmin Lau - Hoop Earrings
- Lexie Galante - Young Rep #1
- Mercedes Blanche - Sorority Girl
- Sanjay Talwar - ER Doctor
- Natasha Bromfield - Intake Nurse
- Chris O'Bray - Focus Group Doctor #3
- Simon Sinn - Focus Group Doctor #2
- David Bronfman - Focus Group Doctor #1
- Cece King - Shannon's Mom
- Wendy Lyon - Facilitator
- Krista White - Mary Jo White
- Neil Foster - Handyman
- Lara Daans - Physical Therapist
- David Tompa - Conference Room Lawyer
- Sean Browning - Mike
- Lesley Faulkner - Elizabeth Sackler
- Catherine Tait - Jillian Sackler
- Maria Ricossa - Else Sackler
- Michèle Kaye - Denise Sackler
- Darrin Baker - Dr. Hartman
- Jonathan Higgins - Dr. Coyle
- Matt Baram - Dr. Robert Kaiko
- Noah Harpster
- Eric Newman
- Alex Gibney
- Micah Fitzerman-Blue
- Patrick Radden Keefe
- Peter Berg
Uzo Aduba interpreta a Edie Flowers en la serie.
Matthew Broderick interpreta a Richard Sackler en la serie.
Taylor Kitsch hace el papel de Glen Kryger.
Dina Shihabi interpreta a Britt Hufford en la serie.
West Duchovny interpreta a Shannon Schaeffer en la serie.
John Rothman interpreta a Mortimer Sackler en la serie.
Clark Gregg interpreta a Arthur Sackler en la serie.
Jack Mulhern interpreta a Tyler Kryger en la serie.
Sam Anderson interpreta a Raymond Sackler en la serie.
Tyler Ritter hace el papel de US Attorney John Brownlee.
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