- Alexandre Chen - Chinese Prisoners and Guards (uncredited)
- Tan Kheng Hua - Baozhai
- Malin Åkerman - Valerie Flame
- Mario Perez - Agent Vargas
- Alejandro Barrios - Campus Guard
- Pierce Kang - Peter
- Erik Betts - CDC G-932 Agent
- Paul Anthony Scott - CDC G-932 Agent
- Dijana Vidušin - Patient
- Eddie Colón - Lorenzo
- Judith Godrèche - Anaïs Desjardins
- Michael Balin - Hanzi
- Dominic Pace - Clinic Guard
- John Kapelos - Matteo Neri
- John Kapelos - Frank Neri
- Antonio Scarpa - Italian Police Officer
- Miloš Vlalukin - Italian Taxi Driver
- Jon Hamm - Derrick Childrens
- David Light - Bob
- Mišo Mihočević - Henri
- Joel McHale - Joel McHale
- Velibor Topic - Nikolai Balodis
- Melody Martišković - Club Patron
- Ithamar Enriquez - Brad
- Jennifer Lafleur - Janet
- Craig Robinson - Edgar Tooby
- Jon Klaft - Alexander
- Feodor Chin - Lead Detective
- Rob Corddry - Blake Downs
- Allen Theosky Rowe - Main Guard
- Diane Sellers - Nurse Jenna
- Matthew Gilmore - Agent Donald
- Jason Ko - Chinese Prison Guard
- James Taku Leung - Scared Guard
- Jesse Wang - Zoo Guard
- Stephen Bralver - CDC Henchman
- Sonny Surowiec - CDC Henchman
- Brian Huskey - Chet
- Lilly Singh - Baroness Von Eaglesburg
- Henry Winkler - Sy Mittleman
- Jason Schwartzman - The Goldfinch
- Erik Audé - Suspicious Doctor
- Emily Berry - Female Patient
- Sarayu Blue - Sloane McIntyre
- Ken Marino - Glenn Richie
- Ken Marino - Glen Richie
- Michael Cera - Sal Viscuso (voice)
- Beth Dover - Nurse Beth
- Zandy Hartig - Nurse Dori
- Krister Johnson - Terry
- Megan Le - Tran
- David Wain - Jim Davidson
- Kimberly Hebert Gregory - Senator Barney
- Lake Bell - Cat Black
- Tom Wright - Director Patten
- Randall Park - Clavis Kim
- Fred Melamed - Professor Waters
- Eric Nenninger - Collins
- Hermie Castillo - Student
- Amber Friendly - News Reporter
- Greg Mills - News Reporter
- Missy Yager - News Reporter
- Trish Hadley
- Rob Corddry
- Krister Johnson
- Jess Dweck
- Emily Heller
- Franny Baldwin
- Matt Novack
Erinn Hayes interpreta a Lola Spratt en la serie.
Rob Huebel interpreta a Owen Maestro en la serie.
Capítulo disponible en las siguientes plataformas:
