- Erica Mer - Charlotte Raymond
- Tracy Middendorf - Anne Harring
- Marshall Cook - Richard Henderson
- Phil Reeves - Sheriff
- Deborah Geffner - Lucy Martin
- Glenn Morshower - Matt Borman
- Dean Norris - David Weiner
- Betsy Brandt - Karen Banks
- Anthony Ruivivar - Carlos Nieto
- Paul Schulze - Mr. Kirkland
- Paul Butcher - Tim Wayne
- Megan Henning - Nancy Hain
- Laura Marano - Brooke Beck
- Dawnn Lewis - Dr. Burton
- Marguerite MacIntyre - Dr. Karen Lowe
- Shannon Woodward - Danielle Johnson
- Susanna Thompson - Dr. Kate Ewing
- Jeremy Ray Valdez - Nestor
- Katija Pevec - Ruby
- Alyssa Shafer - Gracie Harring
- Jolie Jenkins - Lilith
- Frank Novak - Sherman
- Aloma Wright - Desk Nurse
- Melinda Page Hamilton - Sarah Doyle
- Brooke D'Orsay - Melissa Getemer
- Klea Scott - Kim Powell
- Molly Price - Faith Yokas
- Colton Shires - Boy
- Michael Cudlitz - Lt. Troy Adams
- Jose Pablo Cantillo - Rick Hain
- Robert Peters - Kevin
- Robert Curtis Brown - Congressman Doug Lawrence
- Barbara Tarbuck - Eunice
- Lauren C. Mayhew - Sudie Miller
- Mark Harelik - Dr. Lester
- Shea Whigham - Barrett Fidler
- Jesse Borrego - Antonio Baracas
- Patrick Fabian - Gary Riesen
- Jenica Bergere - Renee
- Andrea Thompson - Dr. Lois McCarthy
- Glenn Plummer - Cooly
- Page Kennedy - Gordon Kraft
- Taylor Nichols - Raymond
- Mykel Shannon Jenkins - David Thorn
- Jan Devereaux - Mrs. Ronson
- Kevin Kilner - FBI Agent Paul Maloney
- Jeff D'Agostino - Randy
- Colby French - Keith Jacobs
- Kathryn Harrold - Carla Ballard
- Mark Derwin - Paul Kendall
- Christina Chang - Jenny Small
- Carmen Argenziano - Lt. Col. Bartek
- Peter Outerbridge - Clark White
- Michael Nouri - Wes Douglas
- Robin Bartlett - Dr. Salgado
- Michael Ironside - Ben Graybridge
- Heath Freeman - Josh
- Gil Birmingham - Walter Shephard
- Henri Lubatti - Nurse Tim Miller
- Clare Carey - Lisa Connor
- Johnny Sneed - Dan Harring
- Gregory Itzin - Howard Lewson
- E.J. Callahan - Landlord
- Miracle Laurie - Veronica
- Rosalind Chao - Dr. Kramer
- Lexi Ainsworth - Kaitlin Ronson
- Joyce Guy - Dr. Thomas
- Enrique Castillo - Manager
- Theo Rossi - PFC Joe Vasquez
- Lydia Blanco Garza - Anel Diaz
- Conor O'Farrell - Dr. Gordon
- Chris Massoglia - Jack Connor
- Rich Hutchman - Eric Novack
- Karis Campbell - Kelly Leslie
- Kerry Carney - Dawn Haskel
- Amanda Carlin - Jane Musgrave
- Stephen Markle - Dr. Strickland
- P.D. Mani - Operator
- Mike Randleman - Glen Harvey
- John Bishop - Chad Henry
- Elizabeth Sampson - Waitress
- Dilva Henry - News Anchor
- Donna M. Duffy - Nurse
- Ray Buffer - Parent
- Jeremy Michael Pereira - Baseball Player
- Craig Rees - Arresting State Trooper
- Cheryl White - Sylvia
- Scott Allan Campbell - Tamra's Father
- Natalija Nogulich - Dahlia
- Edward Edwards - Lorenzo Whiteside
- Patty Cornell - Nurse
- Moira Price - Connie Sipe
- Lesley Fera - Gladys Halperin
- Jacory Gums - Soldier
- Alissa Dean - Shelly
- Veronique Vicari - Brenda
- Marc D. Wilson - Officer Cortes
- David Rountree - Officer Gordon
- Jack Rader - Priest
- Daniel Graves - Pharmacist
- Julia Silverman - Shirley Morris
- James Moses Black - Terry
- Andy B. Dardaine - Soldier
- Tiger Mendez - Orderly
- Tony Perez - Raymond Diaz
- Andrew Ableson - Vaughn Kazerian
- Wil Albert - Gerald Borman
- Kristen Ariza - Staff Babysitter
- Elena Finney - Kim
- Alaina Huffman - Estella
- Lonnie Hughes - Dr. Clement Morris
- Kayla Mae Maloney - Sabrina Martin
- Mik Scriba - Peter Smith
- Adam Taylor Gordon - Joey White
- Kavita Patil - Dr. Ansuya Patel
- Corinne Reilly - Leslie White
- Steve Seagren - Ted Martin
- Shanna Collins - Rebecca Stevens
- Jamie Martz - Ryan Uteg
- Jessica Anne Osekowsky - Wendy
- Cameron Bender - Steven Dewalt
- Rand Holdren - Peter Warren
- Terry Savage - Jimmy
- Art Chudabala - Alex Ling
- John Wesley - Mr. Ndulu
- Jeffrey Scott Kelly - Randall Hodge
- Yvans Jourdain - Dr. OnyIuke
- Elyse Donalson - Dr. Eckhart
- Michelle Merring - Ashley
- Mandy McMillian - Melanhie
- Ingrid Sanai Buron - Clerk
- Dave Fennoy - Flute Musician
- Gerry Black - Stanley Price
- Phyllis Applegate - Iris Price
- Richard Roat - Judge Henry
- Stacy Barnhisel - Emily Harris
- Matt Casper - Donnie Brown
- Catherine Wadkins - Cyndi Weaver
- Duane Whitaker - Bar Owner
- Randy Flagler - Clayton
- Marcy Goldman - Ms Tuttles
- Sarah Jones - Belinda
- Blaire Restaneo - Carla Beyer
- Kirsten Severson - Assistant
- Maurice Godin - Dr. John Bender
- Jessica Landon - Lisa Van Adams
- Kevin E. West - Trevor Johnson
- Karen Strassman - Jenna Kirkland
- Carissa Kosta - Production Assistant
- Vincent De Paul - MP3 Guy / Dentist / Porn Star
- Rick Parker - Film crew
- Lisa Waltz - Ms. Johnson
- Katie MacNichol - Nurse Molly Kimbrell
- Jeremiah Birkett - Raymond Jeter
- Don Perry - Mr. Gerica
- Erich Anderson - Landsbury
- Noel Conlon - Joe Burris
- Katrina Nelson - Beth Miller
- Neal Matarazzo - Bill Beck
- Colleen McGrann - Ellie
- Jason Peck - Helicopter Pilot
- Tim Griffin - Detective Chris Leinberger
- Timothy Davis-Reed - Keith Wayne
- Maria McCann - Mindy Wayne
- Deji LaRay - Officer Murphy
- Deborah Carson - Mrs. Connor / Connor's Mother
- Bobby McLaughlin - Dinkins
- Karina Logue - Claire Leinberger
- Hayden Tank - Michael Wayne
- Lola Glaudini - Meredith Beck
- Allen Williams - Gary England
- Adam Lieberman - Daniel Metcalf
- John Hartmann - Dr. Hall
- Jimmy Walker Jr. - Night Watchman / Janitor
- Lisa Gabriel - Law Firm Executive
- Jake Muxworthy - Harry Rush
- Yvonne Jung - Holly Levine
- Victor McCay - Mr. Finch
- Randy Ryan - Richard Rush
- Mark Chaet - Harris
- Michael F. Keenan - ESU Lieutenant
- Larissa Laskin - Donna Lawrence
- David Norona - Kenneth McBride
- Doug Purdy - Reporter
- Lana Antonova - Nicoletta
- Sam Ayers - Medical Assistant
- Kristian Capalik - SWAT Team member
- Walter Cox - Reporter
- Karen Levine - Murdered Victim
- Janelle Marra - Didi Lomax
- Ursula Whittaker - Mindy Manning
- Claudia Besso - Kris Von Getz
- Katie Mitchell - Reporter
- Juan Carlos Cantu - Priest
- Alex Castillo - Berto's Father
- Billy Concha - Insurgent
- Ulysses Estrada - Juan
- Frank Gallegos - Truck Driver
- Bernardo Verdugo - Young Father
- Tarita Virtue - Doctor
- Marc Buckland
Neal McDonough interpreta a Dr Stephen Connor en la serie.
Kelli Williams interpreta a Natalie Durant en la serie.
Christopher Gorham hace el papel de Dr. Miles McCabe.
Anna Belknap hace el papel de Eva Rossi.
Troy Winbush hace el papel de Frank Powell.
Elena Finney hace el papel de Kim.
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