- Nick Nolte - Tank
- Paul Brinegar - Hnchoo
- Hugh Beaumont - Dr. Simpson
- Michael Brandon - Dr. Lensko
- Salome Jens - Dr. Abby Whitten
- Diana Sands - Dr. Marylou Neeley
- Fay Spain - Linda
- Jo Van Fleet - Leah
- Meg Foster - Cassie
- Paul Burke - Dr. Ben Teverly
- Richard Gilliland - David Weldman
- Diane Baker - Sandra Polk
- Dana Wynter - Amanda Scott
- Jill Clayburgh - Beverly Welton
- Belinda Montgomery - Eunice Carston
- Jessica Walter - Maggi Spencer
- Lois Nettleton - Marian Palmer
- Bradford Dillman - Inspector Fellows
- Ed Nelson - Hank
- Lynne Marta - Barbara
- Lynne Marta - Libby Brent
- John Colicos - Harry Weldman
- Jason Bernard - Resident
- Murray Hamilton - Robert Jennings
- Vera Miles - Dr. Gloria Hall
- Andrew Duggan - Dr. Oliver Garson
- Joseph Campanella - Colson
- George Chakiris - Dr. John Martins
- George Chakiris - Alex Solkin
- George Chakiris - Dr. Christopher
- Robert Walden - Dr. Corelli
- Steve Forrest - Dr. Eric Canford
- Vincent Van Patten - Benjy
- Charles Aidman - Pete Howell
- Pat Hingle - Dr. Scott Farring
- Barney Phillips - Warden
- Sheila Larken - Nurse Anne Wittley
- Sheila Larken - Holly
- Willie Aames - Tony
- Willie Aames - Joe Gannon as a Boy
- Willie Aames - Eric
- Willie Aames - Jeff
- JoAnna Cameron - Lainie Jeffries
- Joan Delaney - Janice Wilcox
- Suzy Kendall - Princess Andrea
- Jesse Welles - Ellen Taggert
- Audrey Totter - Nurse Wilcox
- Mary McCarty - Mother Superior
- Mary McCarty - Charlotte
- Helen Boll - Emergency Nurse
- Roberta Lee Carroll - Nurse Dougherty / Night Nurse (as Roberta Carol)
- Gena Rowlands - Karen Coberly
- Gena Rowlands - Frances Delaney
- Celeste Holm - Geraldine Stern
- Bettye Ackerman - Nurse Marsh
- Carol Lawrence - Mrs. Grayson
- Anne Meara - Rose Miller
- Florence Henderson - Jenny Delaney
- Philip Abbott - Stoddard
- Jan Sterling - Florence Brent
- Robert Pine - Jimmy Cole
- George Grizzard - Dr. Tom Forley
- Elizabeth Ashley - Anne Forley
- James Shigeta - Dr. Osaka
- Rita Rogers - Elena Marsh
- Robert Lipton - Bryan Marsh
- Murray MacLeod - Private Burton Reeves
- Janet Wood - Nadine
- Heidi Vaughn - Julie Jennings
- Tom Ormeny - Frank
- Geoffrey Binney - Ken
- Frank Campanella - Sgt. Gifford
- Michael Anderson Jr. - Kevin
- Phyllis Thaxter - Celia Jennings
- Corinne Camacho - Dr. Jeanne Bartlett
- Fred Holliday - Dr. Barnes
- Patricia Stich - Louise
- Stewart Moss - Greg
- William Devane - Dr. Ray Waltham
- Ed Hall - Stan
- Michael Clark - Glen
- Al Checco - Gordie
- Victor Brandt - Tony
- Lincoln Kilpatrick - Daggett
- Robert F. Lyons - Pete
- Christina Crawford - Dr. Myles
- Mia Bendixsen - Jenny Palmer
- Jason Evers - Ken Palmer
- Slim Gaillard - Piano player
- Laurie Prange - Emmy Cranston
- John Abbott - Professor MacIntyre
- Jeff Donnell - Mrs. Hersey
- Dick Kallman - Charlie
- Gary Lockwood - Dr. Carl Webson
- Gary Lockwood - Lorenz
- Barry Sullivan - Professor Tink Polk
- Frank Converse - Pete Barris
- Georg Stanford Brown - Dr. Roy James
- Richard Kiley - Dr. Thomas Patton
- Hal England - Dr. Bill Kebner
- Harv Selsby - Resident
- Evelyn Frank - Nurse
- Ivan Bonar - Dr. Crump
- Ivan Bonar - Dr. Diamond
- Lloyd Kino - Doctor
- Sarah Marshall - Ann Campbell
- Lola Albright - Madeline Barris
- Lola Albright - Grace Jennings
- Karl Held - Arthur Campbell
- Barbara Baldavin - Nurse Holmby
- Pitt Herbert - Manager
- Joyce Van Patten - Paula Eckhart
- Nick Benedict - Intern
- Nick Benedict - Dr. Spahn
- Martin E. Brooks - Lt. Brooks
- Bill Bixby - Dr. Hurst
- Joan Blondell - Doris
- Bob Harks - Policeman (uncredited)
- Bob Harks - Visitor (uncredited)
- Bob Harks - Doctor (uncredited)
- Tom Hallick - Dr. Rolston
- Forrest Tucker - Ollie Wayne
- Jayne Meadows - Nurse Chambers
- Percy Helton - Johnny
- Guy Way - Assistant Coach
- Frank Wilcox - Ashley Drumman
- Peter Brocco - Mr. Honeyman
- Douglas Henderson - Dr. Lee Wrenford
- Katherine Helmond - Rachel Weldman
- Robert Adler - Charles
- Paul Stanley
- Vincent Sherman
- Daniel Petrie
- Harvey Hart
- Michael O'Herlihy
- Chad Everett
- Cliff Gould
- Dick Nelson
- Robert M. Young
- Barney Slater
- Mann Rubin
- Don Brinkley
Chad Everett hace el papel de Joe Gannon.
Gena Rowlands interpreta a Frances Delaney en la serie.
Nick Nolte interpreta a Tank en la serie.
Pat Hingle interpreta a Dr. Scott Farring en la serie.
Gary Lockwood interpreta a Dr. Carl Webson en la serie.
James Daly hace el papel de Paul Lochner.
Audrey Totter hace el papel de Eve Wilcox.
Ed Hall interpreta a Stan Bricker en la serie.
Virginia Hawkins interpreta a Evvie Canford en la serie.
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