- Bhavik C. Pankhania - DC Lee
- Sebastian Knapp - Seth Murdoch
- Robert Lindsay - Max Crockett
- Natalie Mendoza - Mathilde Crockett
- Rosalie Craig - Megan Wattal
- Susannah Fielding - Tamara Valentine
- Jack Ashton - Jack Valentine
- Roger Evans - Mikey Wallace
- Navin Chowdhry - Pete Wattal
- Ellie Kendrick - Elenora Crockett
- Cassie Bradley - Kasha Perry
- Suzanne Packer - Jane Crawford
- Joanna Scanlan - Kelly Mulcreevy
- Kiran Sonia Sawar - Maheeda Abassi
- Caroline Catz - Alison Spiers
- Michele Dotrice - Mary Costair
- Freddie Fox - Miles Stevens
- Hugh Dennis - George Holden
- Charlotte Ritchie - DS Irene Ross
- Cathy Tyson - Jackie Somner
- Patsy Kensit - Barbara Graham
- Rupert Graves - Gordon Elmwood
- Martin Kemp - Mick Elkins
- Vince Leigh - Frankie Marsh
- Rob Brydon - Roy Gilbert
- Rhashan Stone - Algernon 'Al' Ford
- Sarah Parish - Mariel Flynn
- Catherine Tyldesley - Kate Porter
- Niall Wright - Liam Fallin
- Alan Davies - George Gillian
- Caoimhe O'Malley - Elodie Docherty
- Paul McGann - Archie Addington
- Daisy Bevan - Loz Addington
- Bluey Robinson - Gabriel George
- Paul Forman - Marco Capone
- Nicholas Goh - Jian Yang
- Rosie Day - Rose Boleyn
- Nitin Ganatra - Dan
- Siân Phillips - Agnes Gillian
- Ben Batt - Philip Henry / DCI Ethan Fletcher
- Kelvin Fletcher - Donovan Janaway
- Victor Oshin - Jason Greaves
- Femi Nylander - Ollie Greaves
- Jonty Stephens - Caretaker
- Joy McAvoy - Angela McGruder
- Sharon Rooney - Doreen Warren
- Shelley Conn - Hilary O'Doyle
- Tomos Gwynfryn-Evans - Dominique Aubert
- John Thomson - Jimmy Daly
- Natalie Gumede - Deborah Winwick
- George Watkins - Gregg Byrne
- Felipe Bejarano - Robbie Pahura
- Andrew Rothney - Rhuaridh McGruder
- Carl Andersson - Owen Walker
- Allegra Marland - Pearl Walker
- Vincent Moisy - Barman
- Andrew Greenough - Pete
- Saira Choudhry - Alliyah
- Siobhan Hewlett - Penny
- Emily Joyce - Diane
- Richard Dixon - Judge Evan Mannington
- Leah Balmforth - Girl 1
- Romani Wright - Girl 3
- Bex Hainsworth - Keira Roberts
- Max Bennett - Martin Silver
- Gerran Howell - Father Luton
- Pearce Quigley - Hector Ingham
- Joanna Riding - Maeve Gibney
- Joan Iyiola - Jemma Kent
- Stefan Adegbola - Alex Kent
- Toby Stephens - Mark Holgate
- Lydia Leonard - Lucy Holgate
- John Gordon Sinclair - Nevis McLintock
- Pixie Lott - Lola Baker
- Daniel Lapaine - Brad Coleman
- Dipo Ola - Cal Baker
- Jared Garfield - Ian Andrews
- Will Young - Greg DeVere
- Simon Markey - Joe Davis
- Charley Webb - Hilary McLean
- Sophia Myles - Geraldine Bridget DeVere
- Hugh Quarshie - Clarence Adderly
- Robert Goodman - Jinxy Jones
- Michael Howe - Brian Watson
- Bill Blackwood - Steven Hall
- Enzo Squillino Jr. - Steve Green
- Victoria Hamilton - Dora Lang
- Isaura Barbé-Brown - Sandra Blake
- Joy Richardson - Janet Blake
- Lucinda Dryzek - Lynn Wood
- Holli Dempsey - Lilith Wood
- Richard Harrington - Lenny Wood
- Akshay Sharan - Sahir Hassan
- Jason Hughes - Clive Saunders
- Bill Bailey - Paul Watt - Radio DJ (voice)
- Ian Aryeh
- Robert Quinn
- Richard Senior
- Isher Sahota
- Alex Pillai
- Laura Scrivano
- Robert Drummond
- Kam Odedra
- Robert Murphy
- Robert Murphy
- Damien Timmer
- Blair Mowat
Tala Gouveia interpreta a DCI McDonald en la serie.
Jason Watkins interpreta a DS Dodds en la serie.
Claire Skinner hace el papel de Chief Superintendent Mary Ormond.
Lily Sacofsky interpreta a DC Milena Paciorkowski en la serie.
Danyal Ismail interpreta a DC Martin Malik en la serie.
Charlie Chambers interpreta a DC Samuel Goldie en la serie.
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