- Dick Butkus - Crusher Kawalski
- Lynne Marta - Lila Durrant
- Don Johnson - Terry Spence
- Sharon Acker - Deena
- Rick Jason - Mr. Murdock
- Raymond St. Jacques - Psychiatrist
- Paul Petersen - Officer Fredicks
- Paul Petersen - Patrolman
- George Chakiris - Brett Cole
- George Chakiris - Clark Sawyer
- Ernest Borgnine - Buster Ryan
- Charles Dierkop - Choo Choo
- Charles Dierkop - Viney
- Fran Bennett - Lucille
- Jack Hogan - Driver
- Rebecca Holden - Carol LeMaster
- Gayle Hunnicutt - Dr. Kimberley Pryce
- John Davis Chandler - Hank
- Janis Paige - Lauren Calder
- Ramon Bieri - Insp. Cory McFadden
- David Wayne - Bill Houston
- George Wyner - Murray Chase
- George Maharis - Dr. Charles Brockway
- Ruth Kobart - Nurse
- David Cassidy - John Gordon Boyd
- Chuck McCann - Oliver Hardy
- Pat Klous - Officer Andrea Flynn
- Brett Halsey - Brogan
- William Windom - Dr. Walter Belkamp
- Diane McBain - Nurse Marcia Bingham
- Don Stroud - Dirk Bronson
- Lisa Frantz - Nurse
- Amy O'Neill - Rosie
- Lloyd Bochner - Elgin Cody
- Danone Camden - Christie (as Danone Simpson)
- Gary Grimes - Buddy Young
- Kim Sudol - Sharon
- Joan Sweeny - Julia Martin
- Beverly Garland - Sarah Chapman
- Jeanette Nolan - Cattle Annie Hickok
- Susan Tolsky - Bernice
- Robert Rothwell - Doctor
- Joe Penny - Eric Jason
- Lynn Whitfield - Val
- Gary Lockwood - Dr. Owen Denny
- Gary Lockwood - Sheriff
- Edward Mulhare - Malcolm James Abercrombie
- Barbara Rush - Lady Celeste Abercrombie
- Stella Stevens - Clover McKenna
- Bob Harks - Priest (uncredited)
- Anne Jeffreys - Elisabeth Davis
- Stefan Gierasch - Monty Parks
- Andrew Prine - Peter Martin Delaney
- Andrew Prine - Truman Masters
- Mary Wickes - Nellie Cochran
- Lou Ferrigno - Steve Otto
- Nita Talbot - Dr. Jayne Wright
- Dennis Cole - Dr. Warren Cozzeck
- Dorian Harewood - Jerry 'The Rock' Lennox
- Richard Jaeckel - Kip Williams
- George Takei - Sam Shima
- John Beck - Dandy Randy Haines
- Forrest Tucker - Buck Turley
- Werner Klemperer - Felix Randolph
- Pat Crowley - Audrey
- Ted White - Bart
- David S. Cass Sr. - Jacobs
- Chuck Connors - Castanos
- Chuck Hicks - Alvin Ambler
- Tom Simcox - Gershwin
- Douglas S. Cramer
- Leonard Goldberg
- Aaron Spelling
- Lawrence Gordon
George Takei interpreta a Sam Shima en la serie.
Gary Lockwood hace el papel de Sheriff.
Lee Horsley interpreta a Matt Houston en la serie.
Pamela Hensley hace el papel de C.J. Parsons.
Lincoln Kilpatrick interpreta a Lt. Michael Hoyt en la serie.
Buddy Ebsen interpreta a Roy Houston en la serie.
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