- Beth Brickell - Jessica Wells
- Diana Ewing - Amy Farrah
- Peter Donat - Bates
- Richard Egan - Dan Sydon
- George Fisher - Wetzel
- Lance Fuller - Andrews
- Helen Funai - Lin
- Connie Garrison - Blond
- Del Hinkley - 2nd Reporter
- Robert F. Hoy - Huntley
- Katherine Justice - Paula
- Robert Kenneally - Co-Pilot
- Richard Mulligan - Jack Harte
- Marc Ross - Palmer
- Shelley Fabares - Chris / Tina
- Burr DeBenning - Frank
- Rita Gam - Dr. Ross
- Ian McShane - Paul
- Trisha Noble - Millicent
- Dorothy Blackburn - Emme Brady
- Lou Wagner - Webster
- Morgan Jones - Corman
- A.G. Vitanza - Coyle
- Lester Fletcher - Drake
- Jason Evers - Alan Grant
- Pamela Bellwood - Patricia
- Frances Reid - Millie
- Farley Granger - James McKittrick
- John Hoyt - Same Rae
- Helena Carroll - Mrs. Stump
- Lina Raymond - Amanda Miller
- John Yates - Alex Miller
- Sharyn Wynters - Madelon
- Orwin C. Harvey - Security Guard #2
- John Moio - Harlow
- Jim Sheppard - Security Guard #1
- Everett Creach - Tate
- Biff McGuire - Professor Shannon
- Pat Crowley - Lila Faro
- Fred Beir - Billy Jones
- Betty Ann Carr - Cherokee
- Frank Christi - Eddie Danilo
- Logan Ramsey - Eric Frank
- Jeff Morris - Dan Faro
- Robert Miller Driscoll - Bob Anders
- George Brenlin - McCoy
- Bill Baldwin - 1st Man
- Owen Bush - 2nd Man
- Bill Striglos - Reporter
- Alex Cord - Gallagher
- Karen Carlson - Janet Larson
- Richard Kelton - Jed Larson
- Jack Cassidy - Buckman
- Peter Brown - Cassidy
- Bryan O'Byrne - Manning
- Beeson Carroll - Sykes
- Ari Sorko-Ram - Aronson
- Deborah Loomis - Maid
- Ion Teodorescu - Kohner
- Marlyn Mason - Karen Ashley
- Curt Lowens - Alain Ledoux
- Robert Lipton - Vic
- Ahna Capri - Monique Ledoux
- Charles Cioffi - Pike
- Paul Stewart - Joe Delphia
- John McLiam - Charlie Wendell
- Claudia Bryar - Grandmother
- Bryan Scott - Donny Ashley
- Mark Miller - Brandon
- Tom Drake - Fred Wells
- Lee de Broux - Lash
- Pepper Martin - Manning
- Garry Walberg - Doc Slaone
- Clifford A. Pellow - Davis
- Richard LePore - Sgt. Pierce
- Jessica St. John - Chloe Stevens
- Joseph Campanella - Corbett
- Juliet Mills - Caroline Jeffries
- Cesare Danova - Knebel
- Steve Sandor - Gilroy
- Bert Convy - Peters
- Judson Pratt - Guard
- Phillip Pine - Dr. Steve Parker
- Harry Lauter - Dep. Sheriff Gibson
- William Benedict - Scavenger
- Howard Curtis - Warren
- Robert Dunlap - 2nd Cop
- Pippa Scott - Phyllis Hartley
- Clifford David - Ed Glenn
- Sherry Jackson - Elena Bosworth
- Don Gordon - Joe Brennan
- Susan Bay Nimoy - Mrs. Brennan
- Eddie Barth - Taffy
- Rod Colbin - Frank Hartley
- Dick Crockett - Ty
- Patrick Whyte - Butler
- Leslie McRay - 1st Woman
- Nick Dimitri - Candy
- Joanna Barnes - Hannah Bigelow
- Jonathan Goldsmith - Reardon
- Whit Bissell - Rollins
- Carl Betz - Purcell
- Carmen Argenziano - Molinas
- Damon Douglas - Hansen
- Rigg Kennedy - Tourist
- David Knapp - Bannerman
- Gretchen Corbett - Nancy Taylor
- Steven Keats - Kelly
- Joshua Bryant - Bub Stuart
- John P. Ryan - Carl Ainsley
- Anthony James - Eddie Ross
- Herman Poppe - Russ Shanks
- Danny Wells - Cabby
- Eric Braeden - Forbes
- John Durren - Lewis
- Roger Perry - Dr. Ruben
- Murray MacLeod - Nick Strella
- Lynda Carter - Bobbi Dee
- Dane Clark - Joey Bender
- Wes Parker - Cappy Crawford
- John Lupton - Dave Burke
- Diana Herbert - Rose Burke
- Linda Dano - Nurse
- Eileen Chesis - Joan
- Susan Dey - Ellen Tanner
- Jeff Donnell - Ethel
- Charles Drake - Mr. Simmons
- Howard Duff - Dan Mallory
- Joel Fabiani - Kyle Dennison
- Robert Ginty - Griff Tanner
- Huntz Hall - Willy
- Hollis Irving - Mrs. Lake
- Fred Lerner - 1st Cop
- Audrey Totter - Mrs. Simmons, Ellen's mom
- Charles B. Fitzsimons
Anthony James interpreta a Eddie Ross en la serie.
Cesare Danova interpreta a Knebel en la serie.
Anthony Franciosa interpreta a Matt Helm en la serie.
Gene Evans interpreta a Sgt. Fred Hanrahan en la serie.
Laraine Stephens interpreta a Claire Kronski en la serie.
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