- Roslyn Ruff - Josephine May
- Margo Martindale - Miss Horchow
- Steve Rosen - Ernie Turk
- Johanna Day - Advisor
- Mary Jo McConnell - Desk Nurse
- Jeffrey C. Hawkins - OR Doctor #1
- Linda Marie Larson - Lois Tupps
- Danae Nason - Assisting Nurse #1
- Phil McGlaston - Worker
- Duncan Bindbeutel - Doctor at Party (uncredited)
- Roy Pollack - Upscale Party Goer (uncredited)
- Elysia Richards - Nurse (uncredited)
- Tanya Wheelock - College Student (uncredited)
- April Parker Jones - Mrs. Katcher
- Ruby Lewis - Connie
- Kristin Slaysman - Bernadette
- Susan-Kate Heaney - Shirley
- Debbie Jaffe - Nurse Grand
- Clark Moore - Officer Burt
- Doug Hurley - John (uncredited)
- Mae Whitman - Patient
- Lauren Weedman - Quadruplets' Mother
- Nicholle Tom - Maureen
- Ellen Wroe - Ginger
- Bobby Campo - Carl
- Clark Freeman - Operating Doctor #1
- Natasha Sims - Operating Nurse
- Ori Kalmus - Reporter
- Casey Dolkas - Photographer
- Cleo Fraser - Vivian Scully
- Barrett Perlman - Prostitute (uncredited)
- Leah Shaw - Prostitute (uncredited)
- Michael Mantell - Byron
- Martha Hackett - Shirley
- William Nicol - Assistant Doctor
- William Nicol - Operating Doctor #2
- Emily Bridges - Velma
- Dean Chekvala - Mr. Zelinsky
- Kira Sternbach - Marjorie
- Gabe O'Mara - Daniel Zelinsky
- Monica Hewes - Sophia Zelinsky
- Michael Tower - Doug
- Carolyn Crotty - Marilyn
- Jed Sura - Assistant Doctor
- Tony Robinette - Nerdy Man
- Charlotte Chanler - Woman
- Sarah Allyn Bauer - Young Woman
- Faleena Hopkins - Young Estabrooks
- Christian O'Brien - Guest (uncredited)
- Joseph Lyle Taylor - Stan
- Kyle Jones - Glenn
- Emily Davenport - Patty
- Mike Peebler - Anesthesiologist
- Shaun Rylee - Scully Family Friend (uncredited)
- Barry Bostwick - Morris
- Ann Cusack - Harriet
- Caroline Lagerfelt - Barb
- Leah Costello - Louise
- Rachel Kimsey - Nessie Lawson
- Helen Wilson - Dr. Anna Freud
- Eileen Grubba - Lucille
- Jarard Kings - Passenger
- Alan Ruck - Psychiatrist
- John Pollono - David Haas
- Brian R. Norris - Jake Prescott
- Shanna Collins - JoBeth Prescott
- Micah A. Hauptman - Kyle
- Pepper Binkley - Adelaide
- Michael Dunn - Car Dealer
- Mary Catalano - Myrtle
- Alex Chansky - Thug #1
- Craig Baxley Jr - Thug #2
- Finn Wittrock - Dale
- Flex Alexander - Walter
- Brit Shaw - Colleen
- Gary Kraus - Dennis
- Braden Moran - Doctor in Lecture
- Doug McKeon - Reverend Peter Mayfair
- Rob Kerkovich - Jeremy
- Bennet Guillory - Eustace
- Claire van der Boom - Shirley
- Bug Hall - Schacter
- Gil McKinney - Charles
- Kate Fuglei - Marie
- Jeff Doucette - Mr. Langshaw
- Logan Donovan - Travis Banks
- Adam Silver - Tim Deasy
- Jamie Landau - Mason
- Michael Yavnielli - Jacob
- Rick Marcus - Roger
- Olivia May - Peep Show Woman
- Spencer Garrett - Beckett
- Devlin Wilder - Affluent Gentleman (uncredited)
- Anne Dudek - Rosalie
- Joan Severance - Leona
- Mary Passeri - Jean Richards
- Betsy Zajko - Ruby
- Molly Hagan - Sybil
- Zak Barnett - Ted
- Ashley Johnson - Flora Banks
- Carrie Wiita - Penny
- Marlane Barnes - Gladys
- Jennifer Holloway - Ramona
- Nealla Gordon - Nurse Lang
- Milissa Sears - Audrey
- Kelly Lynn Warren - Nurse Gwynne
- Anne Griffin - Kathleen
- Bethany Dwyer - Nurse Pratt
- Michael Cassidy - Dr. Malcolm Toll
- Amanda Jane Cooper - Sissy
- Rebecca Staab - Enid
- Rebecca Larsen - Betsy
- Patty Cornell - Louise
- Susie Schelling - Scrub Nurse
- Susie Schelling - OR Nurse
- William Charles Mitchell - Staffer
- Cheyenne Wilbur - Bus Passenger
- Jason Kravits - Doctor
- James Eckhouse - Dr. Chuck Ingram
- Robert Joy - Dr. Ellenberg
- Tim Ransom - Dr. Rish
- Linara Washington - Lini
- Blake Robbins - Security Guard Brown
- Jocelyn Ayanna - Bitsy
- Wiley M. Pickett - Colonel Stapp
- George Jonson - Major Simons
- Chris Conner - Dr. Begner
- Jed Rees - Dr. Crane
- Lauren Pritchard - Yvonne
- Mark Pestana - The Handler
- Kyla Deaver - Katie Langham
- Will Jennings - Sam Langham
- Joseph Wilson - Administration Doctor (uncredited)
- Rose McIver - Vivian Scully
- Evan Arnold - Dr. Ditmer
- Melinda Page Hamilton - Anne Palmateer
- Ana Walczak - Rose Palmateer
- Larry Poindexter - Paul Palmateer
- Gareth Williams - Dr. Lyons
- Lucas Dixon - Director
- Will Doughty - Elliot Draper
- Josh Randall - Nate Bombeck
- Sarah Sido - Francine Bombeck
- Jonathan T. Floyd - Repairman
- Alexa Alemanni - Maureen
- René Auberjonois - Dr. George Papanikolaou
- Rya Kihlstedt - Tatti Greathouse
- Danny Huston - Dr. Douglas Greathouse
- Kerry O'Malley - Bee Faunce
- Rebekah Ward - Loraine
- Brianne Davis - Serena Buckley
- Michael Bunin - Dr. Broad
- Tru Collins - Angie
- Francesca Ferrara - Nurse
- Donna Pieroni - Joanne
- Bruce M. Stockert - Waiting Room Patient (uncredited)
- Melanie Paxson - Mrs. Turnsworth
- Brandon Scott - Jessie Durkin
- Drew Rausch - Mitch McCaffrey
- Jay Ellis - Dr. Cyril Franklin
- Jillian Reeves - Fannie Durkin
- Vivian Kerr - Ingrid McCaffrey
- Cutter Garcia - Errol
- Nina Daniels - Waiting Room Nurse
- Rebecca Kessler - Maternity Ward Candy Striper (uncredited)
- Julianne Nicholson - Dr. Lillian DePaul
- Greg Grunberg - Gene Moretti
- Keke Palmer - Coral
- Johnny Sneed - Al
- Renée Elise Goldsberry - Morgan Hogue
- Jeremiah Birkett - Everett
- Courtney B. Vance - Dr. Charles Hendricks
- Doug Tompos - Dr. Gibb
- Maitely Weismann - Mariel
- Yetide Badaki - Nurse Williams
- Grasie Mercedes - Nurse Jenkins
- Matt Crabtree - Philippe
- Joy Brunson - Receptionist
- James Holloway - Buell Green Orderly
- Belle Angel - Nurse (uncredited)
- Elizabeth Bogush - Elise Langham
- Barry Watson - Shelley Decklin
- Nicole Steinwedell - Holly
- Kevin Shinick - Mr. Durang
- Yvans Jourdain - Alfred
- Jeff Schine - Kenny Hitchens
- Nick Smoke - Don
- W. Cameron Tucker - Stan
- David Lengel - Clyde
- Josh Fingerhut - Carl
- Jo Galloway - Yvette
- Autumn Withers - Sandra
- Suziey Block - Stag Film Woman
- MAJOR. - Singer
- Mark Parrish - Hank (uncredited)
- Peri Gilpin - Florence Duncan
- Alex Wyse - Elliot
- David Starzyk - Jim Pearson
- Mike Mahaffey - Archie
- Ross Kettle - Tony
- Veronica Mannion - Ellen
- Randy Davison - Wired Male
- Jessica Howell - Meg
- Todd Stroik - Meg's Partner
- Julie Dove - Wired Female
- Mark Cirillo - Ellen's Partner
- Afton Jillian - Fair Debutant (uncredited)
- Cece King - Woman in White (uncredited)
- Joshua Nicks - Pedestrian (uncredited)
- Sterling K. Brown - Marcus
- Erin Cummings - Kitty
- Leonard Earl Howze - Leonard
- Ann Dowd - Estabrooks Masters
- Marin Ireland - Pauline Masters
- Christian Borle - Frank Masters
- Karimah Westbrook - Delila
- Karissa Lee Staples - Cindy
- Baadja-Lyne Odums - Vivienne
- Mataeo Mingo - Nathan
- Marc Evan Jackson - Harold
- Scott Michael Campbell - Roger Corwin
- Lance Barber - Larry
- Derk Cheetwood - Police Officer
- Kandis Fay - Pam
- Charles Christopher - Greg Garwood (uncredited)
- Betsy Brandt - Barbara Sanderson
- Cole Sand - Henry Johnson
- Christopher Clausi - Patron (uncredited)
- Christopher Clausi - Bar Single (uncredited)
- Christopher Clausi - Journalist (uncredited)
- Christopher Clausi - Party Guest (uncredited)
- Kayla Madison - Tessa Johnson
- Artemis Pebdani - Flo Packer
- Jocko Sims - Robert Franklin
- Adam Arkin - Shep Tally
- Bradley White - Dr. Kaufman
- Eric Lange - David Buckland
- Elijah Rock - Manny
- Nick Gillie - Glenn
- Katie Parker - Bernadette
- Noah Robbins - Henry Johnson
- Peter Douglas - Sergeant Marcus Ivey
- Hanna Hall - Linda Einhorn
- Chris Dougherty - Donald Einhorn
- Colin Trahan - Peter Norris
- Liesel Kopp - Delacourt
- Caitlin Gallogly - Tina
- Lashette Showers - Hospital Attendant
- Casey E. Lewis - Clive Dundle
- Mather Zickel - George Johnson
- Necar Zadegan - Queen of Iran
- Waleed Zuaiter - Mohammad aka Shah of Iran
- Maggie Grace - Dr. Christine Wesh
- JB Blanc - Mahdi
- Christopher Grove - Harry Vetters
- Jim Ortlieb - Minister
- Leo Marks - Interviewer
- Brian Day - Photographer
- Joshua Russell - Smoking Playboy (uncredited)
- Eddie Jemison - Hand Massager Salesman
- Reagan Pasternak - Patricia
- Wendy Worthington - Sister Annabelle
- Pete Gardner - Dean Snyder
- Jennifer DeFilippo - Angela
- Phillip Jordan - Ronald Sturgis
- Christian Clemenson - Leslie Riordan
- Eve Gordon - Judith
- Sarah Scott - Elsa
- Briggon Snow - Luther
- Dustin Bayers - Soldier
- Tate Donovan - Graham Pennington
- Allison Janney - Margaret Scully
- Garrett M. Brown - Chancellor Fitzhugh
- Julie Ann Emery - Jo
- Peter MacKenzie - Leslie Farber
- Kurt Oberhaus - Committee for Decency Member (uncredited)
- Keir O'Donnell - Vincent
- Kristen Hager - Isabella Ricci
- Christopher Wiehl - Al Neely
- Susan May Pratt - Joy Edley
- Daniel Rubiano - Thomas
- Angela Sauer - Holly
- Samantha Klein - Eunice
- Beth Fraser - Beth
- Frank Clem - Zookeeper Steve
- Frank Clem - Steve
- Alex Borstein - Loretta
- Bruce Nozick - Newsweek Journalist
- Cary Huff - Doctor (uncredited)
- Cary Huff - Public Defender (uncredited)
- Leah Verrill - Female Study Subject in Film
- Brian Linsley - Male Study Subject
- Catie Boles - Female Study Subject
- Troy Medley - Hank the Janitor
- Sam McMurray - Mr. Avery
- Grant Harvey - Martin O'Reilly
- Whitney Anderson - Cookie
- Lauran September - Emily Hopkins
- Alycen Malone - Stripper (uncredited)
- Laura Silverman - Stephanie
- Jerry O'Donnell - Jack Coleridge
- Bonnie Bower - Wendy
- Lisa Temple - Study Woman #6
- Mariana Tosca - Study Woman #3
- Elizabeth Regen - Mrs. Doughtry (uncredited)
- Kevin Fonteyne - Matt
- Sascha Alexander - Lois Weiland
- Brian Ibsen - Cal
- Matthew McCollum - Young Man
- Drew Marquardt - Frat Guy #3
- Mitch Westphal - Frat Guy #2
- Monique Carmona - Righteous Bar Patron (uncredited)
- Benjamin Koldyke - Paul Edley
- Maury Sterling - Detective David Asher
- Yvonne Zima - Daphne
- Jonathan Kells Phillips - Jacques
- Jeff Lorch - Alain
- Cate Cohen - Woman
- Keli Daniels - Woman #2
- Emily Kinney - Nora Everett
- Colin Woodell - Ronald Sturgis
- Heléne Yorke - Jane Martin
- Brian Howe - Sam Duncan
- Josh Charles - Dan Logan
- Rob Benedict - Jonathan Laurents
- Dennis Cockrum - Francis Masters
- Troy Blendell - Hugh Barringer
- Ace Gibson - Officer
- Dutch Johnson - Guard
- Celeste Pechous - Cindy Loman
- Julia Faye Fisher - Stewardess
- Nolan Gross - 13 Year Old Masters
- Jim Grollman - Driver
- Eric Edwards - Referee
- Jean-Christophe Febbrari - Waiter
- Alysia Reiner - Anita
- Mary Birdsong - Maude Raines
- Brian Unger - Dr. Jeffrey Fahy
- Jake Lockett - Rick
- Paul Cassell - Judge Parks
- Peter Holden - Donald
- Candace Hammer - Celeste
- Katy Dore - Mrs. Gerber
- Joe Calarco - Denny
- Sydney Jay - Gavin
- Toni Christopher - Fay
- Mildred Marie Langford - Shirley
- Jamieson Rhyme - Bud
- Robin Meyer - Gertie
- Cameron Kelly - Blonde Bunny
- Gladys Bautista - Brunette Bunny
- Crystal-Lee Naomi - Heather (Bunny)
- Leslie Murphy - Tina
- Renee Pezzotta - Sister Agnes
- Theo Brennan - Scout
- John Billingsley - Dr. Lloyd Madden
- Rich Sommer - Dale Connolly
- Erin Karpluk - Darleen Connolly
- Alex Weed - Kevin
- Kendra Andrews - Bunny
- Healy Lange - Female Patient
- Aaron Moses - Male Patient
- Judy Greer - Alice Logan
- John Gleeson Connolly - Hugh Hefner
- Bryce Johnson - Lee Dirks
- Gabriel Tigerman - Scotty
- Andre Royo - Sammy Davis Jr.
- Rachelle Dimaria - Dawn Jackson
- Jaret Sacrey - Fred Cox
- Nathan Mohebbi - Todd
- Nicole Carmela - Doe Eyes
- Justin Andrews - Photographer (uncredited)
- Chloe Dworkin - Carly (uncredited)
- Priscilla Quintana - Fabiana (uncredited)
- Ashley Zukerman - Gary Bucksey
- Amanda Quaid - Fran Bucksey
- David Conrad - Mike Schaeffer
- Enuka Okuma - Cleo
- Rafael Feldman - Kyle Schwartz
- Yan Feldman - Lyle Schwartz
- Lily Rains - Cissy
- Eileen O'Connell - Adele
- Armand Vasquez - Waiter
- Tweed Michael Manning - Eye Patch Swinger (uncredited)
- Matt McCoy - Arnold Ketterman
- Jonathan Adams - Judge O. Varga
- Donald Sage Mackay - Prosecutor John Watson
- Tom Kiesche - Jerry
- Beth Kennedy - Juror #11
- James Liebman - Professor / Juror #22
- Joey Vahedi - Literary Man
- Hiep Thi Le - Juror #14
- Robert Arce - Juror #24
- Joel Brooks - Mr. Schiff
- Sarah Silverman - Helen Schiff
- Mike McColl - Richard
- Elise Robertson - Kitty
- Julia McIlvaine - Nurse Trish
- Melissa Center - Surgical Nurse
- Jamila Webb - Pediatric Nurse
- David Pires - Naked Man
- Megan Albertus - Jane
- Aaron Bray - Nudist (uncredited)
- Camryn Manheim - Group Leader
- Jack Laufer - Herb Spleeb
- Rondi Reed - Edith Schiff
- Ivar Brogger - Board Member
- Matthew Bohrer - Roger Fleming
- Laura Schein - Monica Fleming
- Charles Shaughnessy - Charles Clavermore (uncredited)
- Charles Shaughnessy - Charles Clavermore
- Hayes Hargrove - Clerk
- Avery Pearson - Burt
- Hashim Lafond - Dana (uncredited)
- Rick Peters - Nathan
- Frederick Keeve - AA Member (uncredited)
- Frederick Keeve - Client (uncredited)
- Lisa Banes - Nina Clavermore
- Romy Rosemont - Marcia Toplin
- Stephen Root - Harvey Toplin
- Aaron Abrams - Randy
- Steve Bannos - Stavros
- Niecy Nash-Betts - Louise Bell
- Joanna Canton - Cherlyn Green
- Corey Reynolds - James Bell
- Jacqueline Hahn - Brenda
- Chelsea Maidhof - Allison
- Michael Scott Allen - Vance
- Julius Ritter - Geoff
- Melissa Blackwood - Hippie (uncredited)
- Melissa Brownell - Office Worker (uncredited)
- Alex Mannone - Allan (uncredited)
- Jaeden Martell - Johnny Masters
- Jeremy Strong - Dr. Art Dreesen
- Beau Bridges - Dr. Barton Scully
- Alyvia Alyn Lind - Jenny Masters
- Danny Jacobs - Bob Drag
- Frances Fisher - Edna Eshelman
- Michael O'Keefe - Harry Eshelman
- Betty Gilpin - Dr. Nancy Leveau
- David Walton - Bram Keller
- Nick Clifford - Guy
- Kelli O'Hara - Dody
- Aloma Wright - County Clerk
- Brian Slaten - Chuck
- Madeline Ruskin - Holly (uncredited)
- T. Lynn Eanes - Shirley
- Tomas Johansson - AA Meeting Man (uncredited)
- Richardson Cisneros-Jones - Arnold
- Thomas Maier
- Carl Beverly
- Sarah Timberman
- Judith Verno
- Michelle Ashford
- Amy Lippman
Allison Janney interpreta a Margaret Scully en la serie.
Alan Ruck interpreta a Psychiatrist en la serie.
Eddie Jemison hace el papel de Hand Massager Salesman.
Frances Fisher hace el papel de Edna Eshelman.
Josh Charles hace el papel de Dan Logan.
Beau Bridges interpreta a Dr. Barton Scully en la serie.
Margo Martindale interpreta a Miss Horchow en la serie.
Brian Howe interpreta a Sam Duncan en la serie.
Michael Sheen interpreta a William Masters en la serie.
Lizzy Caplan hace el papel de Virginia Johnson.
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