- Gary Busey - Ezra Burnham
- Mark Hamill - Dr. Sam Stein
- María Conchita Alonso - Marie Alexander
- Adam Baldwin - Major James Bowen
- Ronny Cox - Lt. Col. Lester Glade
- Joe Pantoliano - Stan Harbinger
- Callum Keith Rennie - Carlito
- David Warner - Inspector Harold Langford
- Mykelti Williamson - Dr. Michael Alders
- Stacy Keach - Cord van Owen
- Jennifer Beals - Robin Dysart
- Stephen Shellen - Wayne Haas
- Kim Cattrall - Rebecca Highfield
- Ralph Macchio - Dr. Neal Eberhardt
- C. Thomas Howell - Capt. Miles Davidow
- Harve Presnell - Greg Matheson
- Ron Perlman - Lt. Col. Brandon Grace
- M. Emmet Walsh - Sanford Vallé
- John Diehl - Joe
- Cary Elwes - Dr. John 'Jack' Percy Vilmorin York
- Dina Meyer - Dr. Rachel Harris
- Eugene Byrd - Ronnie Dell
- Michael Dorn - Pete Claridge
- Marina Sirtis - Olivia 'Liv' Kohler
- Alan Ruck - Howard Sharp
- Dennis Haysbert - Joshua Finch
- Amanda Plummer - Dr. Theresa Givens
- Thora Birch - Aggie Travers
- Emmanuelle Vaugier - Lisa Dobkins
- Saul Rubinek - Aaron Zgierski
- Lloyd Bridges - Col. Kress
- Frances Fisher - Lady Julia
- Robert Sean Leonard - Robby Archer
- Steven Bauer - Sgt. Waylon Dumar
- Rick Roberts - Andrew McLaren
- Robert Loggia - Justice Earl Clayton
- Diana Scarwid - Elizabeth Halsey
- Xander Berkeley - Terry McCammon
- Nora Dunn - Laura Sinclair
- Robert Foxworth - President Charles Halsey
- Joely Fisher - Amy
- Robert Patrick - Major John Skokes
- Jeffrey Jones - Dr. Scott Perkins
- Burt Young - Captain Parker
- Leland Orser - Dr. Arthur Zeller
- Beau Bridges - Dr. Simon Kress
- Fred Savage - Danny Martin
- Bob Gunton - Clute Nichols
- Julie Harris - Hera
- Annette O'Toole - Commander Lydia Manning
- Eric Keenleyside - Friedkin
- Kirsten Dunst - Joyce Taylor
- Jane Adams - Mona Bailey
- Leonard Nimoy - Thurman Cutler
- Wil Wheaton - Cadet
- Stephen McHattie - Dr. Sherrick
- Bruce Boxleitner - Senator Wyndom Brody
- Charles Martin Smith - Spencer Deighton
- Jon Tenney - Aidan Hunter
- Chris Elliott - Jack Parson
- David James Lewis - Will Carson
- Manny Coto
- Pen Densham
- Joel Goldsmith
Gary Busey interpreta a Ezra Burnham en la serie.
Mark Hamill interpreta a Dr. Sam Stein en la serie.
María Conchita Alonso interpreta a Marie Alexander en la serie.
Adam Baldwin hace el papel de Major James Bowen.
Ronny Cox hace el papel de Lt. Col. Lester Glade.
Joe Pantoliano hace el papel de Stan Harbinger.
Callum Keith Rennie interpreta a Carlito en la serie.
David Warner hace el papel de Inspector Harold Langford.
Mykelti Williamson interpreta a Dr. Michael Alders en la serie.
Stacy Keach interpreta a Cord van Owen en la serie.
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