- Floriana Lima - Dr. Krista Dumont
- Michael Nathanson - Sam Stein
- Jaime Ray Newman - Sarah Lieberman
- Giorgia Whigham - Amy Bendix
- Clancy Brown - Major Schoonover
- Andrew Polk - Col. Morty Bennett
- Rick Holmes - Senator Stan Ori
- Jeb Kreager - Gunner
- C. Thomas Howell - Carson Wolf
- Shohreh Aghdashloo - Farah Madani
- Ripley Sobo - Leo Lieberman
- Raul Torres - Cartel Sicario
- Rob Morgan - Turk Barrett
- Royce Johnson - Sgt. Brett Mahoney
- Kevin Chapman - Kusack
- Corbin Bernsen - Anderson Schultz
- Annette O'Toole - Eliza Schultz
- E.J. Carroll - Doctor Charles
- Todd Alan Crain - David Schultz
- Kacie Sheik - Rhonda
- Jason Nuzzo - Older Airport Suit
- Ben Rezendes - Scut
- Tyler Elliot Burke - Paulie
- Chris Critelli - Lance
- Lucca De Oliveira - Donny Chavez
- Jon David Casey - Mickey O'Hare
- Jagger Nelson - Rex
- Teri Reeves - Marlena Olin
- Joseph D. Reitman - Creepy Ed
- Derek Roberts - Officer Lawrence
- Kareem Savinon - Officer Smith
- Tabitha Holbert - Delia Robinson
- Alexa Davalos - Beth Quinn
- Darlene Violette - Waitress
- Owen Burke - Mazur
- Timothy Stickney - OIG Agent
- Delaney Williams - O'Connor
- Shezi Sardar - Ahmad Zubair
- Ambre Anderson - Businesswoman
- Michael Kennealy - Cop
- Tim Guinee - Clay Wilson
- Ilfenesh Hadera - Mistress
- Ramón Olmos Torres - Soldier
- Graham Wolfe - Weems
- Quincy Chad - Geiger
- Andrea Leigh - Carla
- Porter Kelly - Nurse
- Geoffrey Cantor - Mitchell Ellison
- Dov Davidoff - Ricky Langtry
- Marlene Ginader - Producer
- Pat Kiernan - Newscaster 1
- Roma Torre - Newscaster 2
- Kathleen Mary Carthy - Barmaid
- Leajato Amara Robinson - FBI Agent
- Vishaal Reddy - Aide
- Valisa Tate - Birthday Girl (uncredited)
- Jordan Mahome - Isaac
- Amanda Bruton - Cop
- René Ifrah - Officer Jack
- Adelind Horan - Computer Tech
- Houshang Touzie - Dr. Hamid Madani
- Nicolette Pierini - Lisa Castle
- Aidan Pierce Brennan - Frank Castle Jr.
- Kobi Frumer - Zach Lieberman
- Josh Caras - Carl
- Yadira Correa - Cop
- Alexander Notkin - Sergei Konchevsky
- Avery Mason - Ringo
- Peter Albrink - Johnny
- Adrian Alvarado - Eddie
- Lucas Kane - Drunk
- Daniel Tirado - Paramedic
- Lenny Thomas - Customer
- Shooter Jennings - Shooter Jennings
- Ashley August - Debbie
- Todd Ryan Jones - Davy
- Ian Poake - Tech
- Michael Pemberton - Lieutenant Ferrara
- Joe Holt - Sheriff Hardin
- Brandon Gill - Deputy Ken Ogden
- Rudy Eisenzopf - Deputy Dobbs
- Alex Pires - I.T. Guy
- Charlie Romanelli - Militia
- Tony Plana - Rafael Hernandez
- Johnny Pozzi - Rick
- Thomas G. Waites - Arthur Walsh
- Preston Christopher Lawrence - Bartender
- Ilia Volok - Kazan
- Keith Jardine - Russian Thug
- Manny Ureña - Jimbo
- Dikran Tulaine - Nikolai Poloznev
- Decater James - Veteran
- Chris Barnes - Tow Truck Driver
- Jordan Dean - Jake Nelson
- Jordan Dean - Jake Campbell
- Mary Elizabeth Mastrantonio - Marion James
- Mike Figueroa - Geno
- Diego Aguirre - Mike
- Cecelia Antoinette - Lillian
- Nafeesa Monroe - Inspector Monroe
- Kara Young - Wendy
- Greta Quispe - Clerk
- Steve Mack - Security Guard
- Charles Brice - Bobby
- Bianca LaVerne Jones - Cop
- Brendan Walsh - Moke
- Jordyn DiNatale - Shantel
- Flora Wildes - Lanie
- Justin Paul - Martin
- Allie McCulloch - Rebecca Pilgrim
- Jimi Stanton - Todd
- Derek Goh - Danny
- Ted Koch - Bob Wick
- Shevy Gutierrez - ESU Cop
- Jeffrey Brabant - Marine #1
- Manny Galan - Marine #3
- Jes Davis - Hooker #2
- Kate Rigg - Dr. Mason
- Samuel María Gómez - José
- Eboni Booth - TV Reporter
- Anthony Ruiz - Vendor
- Zell Steele Morrow - Michael Pilgrim
- Brian Adam DeJesus - Gang Leader #1
- Christopher R Ellis - Moose
- David R. Nash - Leader
- Ross Andru
- John Romita Sr.
- Gerry Conway
- Alan Fine
- Joe Quesada
- Jim Chory
- Felicia D. Henderson
- Jeph Loeb
- Stan Lee
- Tyler Bates
C. Thomas Howell interpreta a Carson Wolf en la serie.
Kevin Chapman interpreta a Kusack en la serie.
Mary Elizabeth Mastrantonio interpreta a Marion James en la serie.
Shooter Jennings hace el papel de Shooter Jennings.
Annette O'Toole interpreta a Eliza Schultz en la serie.
Jon Bernthal interpreta a Frank Castle / Punisher en la serie.
Ben Barnes interpreta a Billy Russo en la serie.
Amber Rose Revah interpreta a Dinah Madani en la serie.
Josh Stewart interpreta a John Pilgrim en la serie.
Jason R. Moore interpreta a Curtis Hoyle en la serie.
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