- Sonja Sohn - Captain Betty Audrey
- Frankie Faison - Henry 'Pop' Hunter
- Rachael Taylor - Patricia 'Trish' Walker (voice)
- Jaiden Kaine - Zip
- Jessica Henwick - Colleen Wing
- Ron Cephas Jones - Bobby Fish
- Elden Henson - Foggy Nelson
- Chaz Lamar Shepherd - Raymond 'Piranha' Jones
- Finn Jones - Danny Rand
- Stephen Rider - Blake Tower
- Rob Morgan - Turk Barrett
- Kevin Mambo - Sheldon Shaw
- Sahr Ngaujah - Anansi
- Gabrielle Dennis - Tilda Johnson
- Heather Simms - Auntie Ingrid
- Frank Whaley - Rafael Scarfe
- Michael Kostroff - Dr. Noah Burstein
- Felix Betancourt - Ricky
- Lynn Marocola - FDNY Paramedic (uncredited)
- Lynn Marocola - NYPD Police Officer (uncredited)
- Antonique Smith - Detective Nandi Tyler
- Chris Chirdon - Officer
- S. Robert Morgan - Oliver
- Raphael Saadiq - Raphael Saadiq
- Ester Jiron - Girl #1
- Jermel Howard - Shameek Smith
- Warner Miller - Tone
- Steven Ted Beckler - Nate
- Peyton Alex Smith - Chauncey
- Jacob Vargas - Domingo Colon
- Brian Marc - Wilfredo 'Chico' Diaz
- Jason Altman - Police Officer
- Darik Bernard - Crispus Thug
- Tationna Bosier - Strung Out Girl
- Gabe Bettio - Detective
- Charles Bradley - Charles Bradley
- Chance Kelly - Albert Rackham
- Craig muMs Grant - Squabbles aka Reggie
- Thomas Q. Jones - Comanche
- Marston Fobbs - Keely
- Harry Sutton Jr. - Guard 1
- Miles Mussenden - Guard 3
- Chris Lazzaro - Inmate
- Michael Chmiel - Cameraman
- Dawn-Lyen Gardner - Megan McClaren
- Dawn-Lyen Gardner - Megan McLaren
- Robert Keiley - Firefighter 2
- Elijah Boothe - Young Cottonmouth
- Elijah Boothe - Young Adult Cottonmouth
- Amy Halldin - Newscaster 1
- Malika Nzinga - Newscaster 2
- Edwin Freeman - Young Adult Pop
- Edwin Freeman - Young Pop
- Joseph Harrell - Drill Sergeant
- Stephen Grove Malloy - Darrell Mitchell
- Kelvin McGrue - Koko
- Stephen Hill - Bert Hunter
- Jade Johnson - Blue
- Ian Unterman - Jerome
- Brian D. Coats - Pablo
- Dared Wright - Sergeant Maclean
- Michael Basile - Cop
- Wayne Pretlow - Banker
- Nore Davis - Bystander 1
- Marcus de Vere - Gangster
- Ignacyo Matynia - Thug
- Jidenna - Jidenna
- Karen Pittman - Inspector Priscilla Ridley
- Karen Pittman - Deputy Chief Priscilla Ridley
- Shemeka Wright - Family Member
- Manny Perez - Lieutenant Perez
- Danny Henriquez - Diontey
- Jeremy Sample - C-Money
- Andrew Rein - Eric Fraser
- Kendall Lloyd - Port Security Officer
- Danny Johnson - Ben Donovan
- Michaela Jaé Rodriguez - Sister Boy
- Ephraim Sykes - Donnie
- R. Marcos Taylor - Amos
- Robert Jimenez - Manny
- Qurrat Ann Kadwani - Reporter 2
- J. Alphonse Nicholson - Darnell
- Tyler Evans - Cop 1
- Guy Fernandez - Cop 2
- Khalil Maasi - Neville
- Shing Ka - Peter
- Franky G - Juan Carlos
- Natalie Paul - Dana Stryker
- J. Bernard Calloway - Detective Dorsey
- Gene Harrison - Officer Jackie Albini
- Helmar Augustus Cooper - Reverend John Pope
- Jennifer Brito - Female Uniformed Officer
- Roger Wayne - Male Uniformed Officer
- Thiree Pinnock - Angry Teen
- Marquis Rodriguez - Darryl
- Julian Rozzell Jr. - Vendor
- Clark Jackson - Damon Boone
- Michael-Scott Druckenmiller - FDNY Paramedic
- Anthony Vaughn Merchant - Protester #2
- Robyn Payne - Reporter 2
- Robyn Payne - Female Reporter
- A.J. Franklin - Protester #4
- DeLance Minefee - Protester #5
- Edelen McWilliams - Kerry Duggan
- Method Man - Cliff 'Method Man' Smith
- Heather B. - Heather B.
- Roberto De Felice - Ernesto
- David Chen - Bryce
- Andrew Casanova - Michael
- Eddie Clark - John
- Justin Swain - Detective Mark Bailey
- Jeremiah Craft - D.W. Griffith
- John Clarence Stewart - Alex Wesley
- Deborah Ayorinde - Candace
- Jared Kemp - Teenage Willis Stryker
- Sônia Braga - Soledad
- Lee Sellars - Sergeant Jacob 'Jake' Smith
- P.J. Marshall - ESU Lieutenant Mario Green
- John Garrett Greer - Mikey
- Ben Horner - Marshall #2
- Clem Cheung - Jin Lin
- Anthony Aroya - Victor
- Mike Britt - Eddie Axton
- Fab 5 Freddy - Fab 5 Freddy
- Reg E. Cathey - James Lucas
- Reg E. Cathey - James Lucas (voice)
- Corri English - Alicia
- Joshua Rivera - Cameraman
- Sharon Jones - Sharon Jones
- Otto Sanchez - Arturo 'El Rey' Gomez III
- Macc Plaise - Nigel Garrison
- Jacob Wallach - Joey Ross
- Eric Lockley - Corner Kid
- Malcolm C. Murray - Waiter
- LaTanya Richardson Jackson - Mama Mabel Stokes
- LaTanya Richardson Jackson - Mama Mabel
- Curtiss Cook - Uncle Pete
- Curtiss Cook - 'Pistol Pete' Stokes
- Donald Harrison - Donald Harrison
- Michelle Beck - Drea Powell
- Andrew Pang - Detective Donnie Chang
- Andrew Pang - Detective Chang
- D-Nice - D-Nice
- Carolyn Michelle Smith - Wendy Dunnavant
- Tristan Laurence Perez - Male Reporter
- Tristan Laurence Perez - Reporter #1
- Tristan Laurence Perez - Reporter 1
- Venida Evans - Elderly Neighbor
- Stephanie Berry - Older Woman
- Paul Bomba - Detective
- Jemele Hill - Jemele Juanita Hill
- Michael Smith - Michael Smith
- Gary Clark Jr. - Gary Clark Jr.
- Dorian Missick - Dontrell 'Cockroach' Hamilton
- Jeorge Bennett Watson - Mark Higgins
- Hakim Callender - Mortimer 'Mr. Fish' Norris
- Derrick Simmons - EMT #1
- Alyma Dorsey - EMT #2
- Geoffrey Canada - Geoffrey Canada
- Esperanza Spalding - Esperanza Spalding
- R.A. Guirand - Gideon Shaw
- Erika Rolfsrud - Mrs. Hansen
- Los Jones - Ray Ray
- Harlin C. Kearsley - Handyman
- Mike Cabellon - Young Man
- Peter Jay Fernandez - Captain Tom Ridenhour
- Robert Neary - Chase Brunski
- Steven Cachie Brown - Yardie
- Steven Cachie Brown - Styler #1
- Ian Lyons - John Epps
- Aurora Leonard - Cara
- Bisserat Tseggai - Lola
- Jason Chu Wing-Tong - Broker #1
- Jason Abrams - Broker #2
- Aviel Ayoung - Broker #3
- Carme Boixadera - Model #1
- Freddie Kuguru - Patron
- Adam Aseem Tiwari - Technician Steve
- Donald Brooks - Styler #2
- Ghostface Killah - Ghostface Killah
- John Scurti - Dr. Gabe Krasner
- Taylor Selé - Brendan
- Dapper Dan - Dapper Dan
- Stephen Marley - Stephen Marley
- Melanie Nyema - Melanie Nyema
- Sophia Stephens - Sophia Stephens
- Parisa Fitz-Henley - Reva Connors
- Carlos Guity - Father
- Gene Presendieu Jr. - Gypsy Cab Styler
- Bahiyah Hibah - Patrol Cop
- Jamar Greene - Goon One
- Jamar Greene - Goon
- Jade Wu - Connie Lin
- Camrus Johnson - Torre
- Justin Ruff - Young Botanist
- Chaunice Chapman - Woman
- Heaven Michelle McCoy - Young Girl
- Faith Evans - Faith Evans
- Jadakiss - Jadakiss
- Rey Lucas - Detective Tomas Ciancio
- Ashley D. Kelley - Young Nurse
- Shannon Harris - Gwen
- Toree Alexandre - Young Mariah
- Krista Donargo - Female Pastry Chef
- Melissa Rakiro - Stephanie's Sister
- Anthony Salvador Lewis - Reporter #2
- Hope Blackstock - Reporter #4
- Henry Yuk - Hai-Qing Yang
- Cassandra Freeman - Patricia Wilson
- Darius Kaleb - Lonnie Wilson
- Ninja N. Devoe - Aisha Axton
- LaTonya Borsay - Janis
- Jen Casey - Kiki
- Billy Carter - Auctioneer
- Kemo Coleman - Nervous Guard
- KRS-One - KRS-One
- Sean Ringgold - Sugar
- Tijuana Ricks - Thembi Wallace
- Annabella Sciorra - Rosalie Carbone
- Delissa Reynolds - Kalinda Porter
- Marcus Choi - Eric Hong
- Kymbali Craig - Jamaican Woman
- Cheryl Lewis - Black Female Inmate
- Joanna Shelmidine - Older Italian Female
- Harold Surratt - Robert
- Ivan Moore - Joe
- Thomas Silcott - Larry
- Twinkle Burke - Mother
- Tim Moriarty - A.U.S.A. Colin Dunbar
- Cris Tucci - Italian Goon
- Truck Hudson - Goon Three
- Jelani Cobb - Jelani Cobb
- Rakim - Rakim
- Adrian Younge - Adrian Younge
- Ali Shaheed Muhammad - Ali Shaheed Muhammad
- Jefferson Cox - Mob
- Daniel Keith - Detective Jerry
- David Healy - Reporter 1
- David Healy - Reporter #3
- Sway Calloway - Sway Calloway
- Mahershala Ali - Cornell 'Cottonmouth' Stokes
- Erik LaRay Harvey - Willis 'Diamondback' Stryker
- Jim Chory
- Akela Cooper
- Alex R. Wagner
- Jeph Loeb
- Cheo Hodari Coker
Clem Cheung interpreta a Jin Lin en la serie.
Franky G interpreta a Juan Carlos en la serie.
Curtiss Cook interpreta a 'Pistol Pete' Stokes en la serie.
John Scurti interpreta a Dr. Gabe Krasner en la serie.
Mike Colter hace el papel de Luke Cage.
Alfre Woodard hace el papel de Mariah Dillard.
Simone Missick interpreta a Misty Knight en la serie.
Theo Rossi interpreta a Hernan ‘Shades’ Alvarez en la serie.
Mustafa Shakir interpreta a John 'Bushmaster' McIver en la serie.
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