- David Tennant - Kilgrave
- David Tennant - Kilgrave (voice)
- Sarita Choudhury - Kith Lyonne
- Jeremy Bobb - Gregory Sallinger
- Tiffany Mack - Zaya Okonjo
- Terry Chen - Pryce Cheng
- Leah Gibson - Inez Green
- Erin Moriarty - Hope Shlottman
- Wil Traval - Will Simpson
- Rosario Dawson - Claire Temple
- Susie Abromeit - Pam
- Robin Weigert - Wendy Ross-Hogarth
- Kobi Libii - Zack
- Joseph Ragno - Roy Healy
- Ian Blackman - Bob Shlottman
- Deborah Hedwall - Barbara Shlottman
- Nedra Marie Taylor - Gina
- Juri Henley-Cohn - Gregory Spheeris
- Aaron Costa Ganis - Bobby
- Clarke Peters - Det. Oscar Clemons
- Leslie Lyles - Maureen Denton
- Parisa Fitz-Henley - Reva Connors
- Kieran Mulcare - Ruben
- Colby Minifie - Robyn
- Birkett Turton - Holden
- Andréa Burns - Angie
- Jessica Hecht - Audrey Eastman
- Ricky Paull Goldin - Carlo Eastman
- Keil Oakley Zepernick - Bodyguard #1
- Richard Brevard - Matt / Bodyguard #2
- Jeremy Sample - Bodyguard #3
- Brett Azar - Len Sirkes
- Dante E. Clark - Antoine
- Sean Weil - Charles Wallace
- Mike Houston - Harvey
- Royce Johnson - Sgt. Brett Mahoney
- Elizabeth Cappuccino - Young Jessica
- Catherine Blades - Young Trish
- James Freedson-Jackson - Young Kilgrave
- Miriam Shor - Alisa Jones
- James Colby - Brian Jones
- Billy McFadden - Phillip Jones
- Michael Siberry - Albert Thompson
- Lisa Emery - Louise Thompson
- Thomas Kopache - Dr. Kozlov
- Colin Moss - Justin Boden
- Michelle Hurd - D.A. Katrina Reyes
- Amanda Warren - Dr. Gallo
- Taylor Dior - Chanise
- Nichole Yannety - Female Intern / Nicole
- Ruibo Qian - Mei
- Jon Norman Schneider - Maître'd
- Peter Davenport - Man
- Brian J. Carter - Doorman
- David S. Lomax - Cabbie
- Thom Sesma - Doctor David Kurata
- Neimah Djourabchi - Andre
- Athena Colon - Yuliana
- Jan Kutrzeba - Polish Mechanic
- Ben Kahre - Jack Denton
- Gabriel Sloyer - Trainer
- Josiah Nolan - Rugby #3
- David Shumbris - Odd Man
- Sonnie Brown - Nurse
- Jos Laniado - Portuguese Father
- John Adams - Dad
- Brian Edwards - Officer Cooper
- Eli Bridges - Stoner
- Tom DiNardo - Crackpot
- Danielle Ferland - Clair / Frumpy Cellist
- Gillian Glasco - Emma / Actress
- Zak Steiner - Brad
- Ryan Farrell - Jackson / Trendy Guy
- Kubbi - Distraught Woman
- Paul Pryce - Donald
- Mary Looram - Old Woman
- Jazmin Luperena - Tweaky
- Jay Hieron - Bodyguard #4
- Brian Faherty - Boss
- Jeté Laurence - Little Girl
- Sydney Morton - Patron
- Nnamdi Nwosa - Mugger #1
- Evan Dane Taylor - Mugger #2
- Elliot Santiago - Cabbie
- Jesmille Darbouze - Serena
- Kevin Yamada - Mr. Lin
- Danielle K. Thomas - Prison Nurse
- Alexis Wolfe - Dealer
- Patrick Richwood - Homeless Man
- Mauricio Ovalle - Contractor
- Bryan Winston - Man
- Vincent Oddo - Bartender
- Monte Bezell - Cop #1
- Tanya Perez - Cop #3
- Maya Tanida - Girl #1
- Kathleen Doyle - Mrs. Elizabeth De Luca
- Mazin Akar - Hank
- Ryan Jonze - Chuck
- Robert Verlaque - Laurent Bouchard
- Slate Holmgren - Robinson
- Michael Markiewicz - Ken
- Mark Lotito - Desmond Tobey
- Larissa Laurel - Hostage Negotiator
- Stacey van Gorder - Wife
- Craig DiFrancia - Cop #1
- Michael Rosete - Cop #2
- Lauren Lim Jackson - TV Newscaster
- Owen Asztalos - 10 Year Old Boy
- Cherelle Cargill - E.R. Doctor
- Lana Young - Detective
- Bonnie Rose - Female Guard
- KeiLyn Durrel Jones - Male EMT
- Daniel Marcus - Maury Tuttlebaum
- Chester Jones III - Detective
- Kaira Klueber - Female Jogger
- Stewart Steinberg - Old Male Dog Owner
- Jinn S. Kim - Truck Driver
- Patricia R. Floyd - New Attendant
- Berto Colon - Commando #2
- Chazz Menendez - Taxi Driver
- James Augustus Lee - Venue Manager
- Mandela Bellamy - UPS Driver
- Alex Monsky - City Worker
- Alex Boniello - Punk Kid
- Tiffany Green - Bunny Wiles
- Frank De Julio - Nurse Brad
- Lia Yang - Nurse Chung
- Cecelia Riddett - Old Woman
- Mack Kuhr - Male Surgeon
- Hal Ozsan - Griffin Sinclair
- Angel Desai - Linda Chao
- Jacqueline Antaramian - Doctor Zakarian
- Anthony Grasso - Ian
- Jay Klaitz - Robert "Whizzer" Coleman
- Ashlie Atkinson - Mavis
- Shayan Shojaee - Rafi
- Christopher McFarland - Ash
- Jim C. Ferris - Kyle
- Andrew MacLarty - Evan
- Keilly McQuail - Nutty Woman
- Narada Campbell - Track-Suited Client
- Ruth Aguilar - Marina
- Marco Greco - Security Guard
- Rachel McPhee - Woman in Robe
- Lisa B. Tharps - Detective Ruth Sunday
- James McCaffrey - Maximilian "Max" Tatum
- Cece King - Makayla
- Adaku Ononogbo - Sheena
- Joel Leffert - Leland
- Joseph Castillo-Midyett - Isaiah
- Jake Boyd - Young Trader
- Haley Murphy - Young Actress
- Elden Henson - Foggy Nelson
- Ben Van Bergen - Dr. Tiboldt
- Arnie Burton - Eugene
- Erik Frandsen - Neighbor
- Xavier Rodney - Paparazzo #1
- Ryan Bourque - Paparazzo #2
- Victoria Cartagena - Sonia
- Alan R. Rodriguez - Chaz
- Spenser Granese - Gary
- DeAriesha Mack - Ex-Military Woman
- Marco Torriani - Sulky Teenager
- Barbara Kingsley - Sally
- Maceo Oliver - Nick
- DeShawn White - Marlene
- Reema Sampat - Teaser Date
- Victor Pagan - Homeless Man
- Frank Licari - Tabloid #1
- Tuffy Questell - Cabbie
- Malachi Nimmons - Man
- Callum Keith Rennie - Dr. Karl Malus
- Daniel Everidge - Dave
- Teresa Yenque - Abuela
- Mel Johnson Jr. - Justis Ambrose
- Gary Lee Mahmoud - Club Manager
- da'Vinchi - Eric Ambrose
- LeeAnne Hutchison - Luanne
- Steve Grodewald - Scary Looking Dude
- Mat Vairo - Stirling
- Sasha Hutchings - Kourtney
- Evan Hall - Wyatt
- Kevin Csolak - Keith
- Justin Sintic - Gus
- Eden Marryshow - Shane
- Emmy Harrington - Lila
- Alfredo Narciso - Ronald Garcia
- Arlene A. Mcgruder - Bus Driver
- Carlos Arce Jr. - Attendant
- Brian Hutchison - Dale
- Sarah Dacey Charles - Chemist
- Brian McCarthy - First A.D.
- Thaddeus Daniels - Lead Guard / Guard #1
- Jennifer Fouché - Marilyn
- Manni L. Perez - Tina
- Kate Greer - Francine
- Myrna Cabello - Dr. Torres
- Fernando Mateo Jr. - Bouncer
- Rob Morgan - Turk Barrett
- Lane Napper - Vernon
- Shakina Nayfack - Frankie
- Bruce Baek - Driver
- Chris Lamberth - Male Nurse
- Buzz Roddy - Dad
- Cathy Salvodon - Trudy
- Matthew Streeter - SWAT Commander
- Deysha Nelson - Little Girl
- Kenneth De Abrew - Clerk
- Kiri Hartig - Yogi
- Dean Neistat - Undercover Cop
- Kelly Miller - Middle-Management Guy
- Kevin Chacon - Vido Arocho
- Max Miller - Frat Bro #1
- Lynn Marocola - FDNY Paramedic (uncredited)
- Lynn Marocola - NYPD Officer (uncredited)
- Rosalyn Coleman - Dr. Irene Bickell
- Paco Lozano - Russell
- Leticia Castillo - Ana Silva
- Spencer House - Reid Pearson
- Gus Birney - Birdie
- Barbara Tirrell - Sal Blaskowski
- Chris McGinn - Sharon
- Chris McGinn - Bartender
- Christina Shea-Wright - Amber
- Jessica Frances Dukes - Grace
- Nancy Lemenager - Cassie's Mom
- Rebecca De Mornay - Dorothy Walker
- John Ventimiglia - Detective Eddy Costa
- Dante Costabile - Cody Willamet
- John Benjamin Hickey - Peter Lyonne
- Alan Mingo Jr. - Host #1
- Cristala Carter - Reporter
- McLean Peterson - Girlfriend
- Jonathan Holtzman - Mugger
- Gabriela Garcia - Clothing Rep
- Matt Weiss - Andrew Brandt
- Ezra Barnes - Doctor Purks
- Pedro Carmo - Gallerist
- Zuhdi Boueri - Nurse
- Anthony J. Gallo - Street Vendor
- Michael Kelberg - Man on Street
- Tobee Paik - P.A.
- Sandra Glinka - Graduate Student
- Airon Armstrong - Dwayne Blaskowski
- Lori Hammel - Reyna Pincer
- Jennifer Lim - Carly
- Dan Shor - Mathias Cole
- Ivica Marc - Gor
- Leslie Frye - Female Bohemian Neighbor
- Rachel McKeon - Char
- Rachel McKeon - Assistant
- Maury Ginsberg - Steven Benowitz
- Michael Rosen - Laurent Lyonne
- Curran Connor - Chef Caspar Marx
- Lisann Valentin - Uniform Cop
- Tijuana Ricks - Thembi Wallace
- Mary B. McCann - Chief Ronnie Velasco
- Mateo Gómez - Manuel Silva
- Samuel J. Joseph - News Photographer
- Scott Stangland - Joby
- Ellen Mah - Mona Lee
- Libya Pugh - Adoption Counselor
- Joseph Haro - Waiter
- Andrea Patterson - Security Guard #1
- Grayson Berry - Reporter #1
- Jaqueline Arnold - Staring Passerby #2
- Anthoula Katsimatides - Detective Defford
- Eddie K. Robinson - Orderly
- Nayib Felix - Security Officer
- Sandra Elizabeth Rodriguez - Morgue Attendant
- Kim Fischer - Receptionist
- Kevin R. Free - Stage Dad
- Audrey Grace Marshall - Young Trish
- Larry Mitchell - Officer Carl Nussbaumer
- Chaske Spencer - Jace Montero
- Mark Kenneth Smaltz - Gene Burchell
- Bowman Wright - Officer Pickett
- Betsy Hogg - Casting Assistant
- Denise Pillott - Uniformed Officer
- Lindsey Alley - Stage Mom
- Aneesh Sheth - Gillian
- Jacob Laval - Grandson
- Gio Castellano - Bailiff
- Taprena Michelle Augustine - Medical Assistant
- Jamie Neumann - Brianna 'Berry' Gelden
- Roman Roytberg - Alex Sokolov
- Wayne Maugans - Demetri Patseras
- Jillian Lebling - Nora Patseras
- Manuel Penichet - Male Traumatized Witness
- Daniel O'Shea - Male Lookie-Loo
- Kristopher Kling - Teller
- Gopal Lalwani - Pizza Guy
- Satomi Hofmann - Anchorwoman
- Cadden Jones - Reporter #2
- Shravan Amin - Reporter #3
- Shawn Black - NYPD Court Officer (uncredited)
- Gabriel Lopez - Mario
- Gregory Abbey - Mitch Yasdan
- Ari'el Stachel - Victor
- Guy A. Fortt - Guard
- Sam Encarnacion - Jorge
- David R. Nash - Guard
- Charlton Lamar - Officer
- Alan Fine
- Joe Quesada
- Courtney Saladino Gurney
- Alex R. Wagner
- Jeph Loeb
- Stan Lee
Callum Keith Rennie hace el papel de Dr. Karl Malus.
Mike Colter hace el papel de Luke Cage.
Dan Shor interpreta a Mathias Cole en la serie.
Krysten Ritter interpreta a Jessica Jones en la serie.
Rachael Taylor hace el papel de Patricia 'Trish' Walker.
Eka Darville interpreta a Malcolm Ducasse en la serie.
Benjamin Walker hace el papel de Erik Gelden.
Carrie-Anne Moss hace el papel de Jeryn 'Jeri' Hogarth.
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