- Taj Mahal - Self
- B.B. King - Self
- Ike Turner - Self
- Salif Keita - Self
- Ali Farka Touré - Self
- John Lee Hooker - Self (archive footage)
- Corey Harris - Self
- Son House - Self (archive footage)
- Lead Belly - Self (archive footage)
- Keb' Mo' - Self
- Martin Scorsese - Self
- Muddy Waters - Self (archive footage)
- Chris Thomas King - Blind Willie Johnson
- David F. Hughes - Art Laibely (as David Hughes)
- T Bone Burnett - Self (as T-Bone Burnett)
- James "Blood" Ulmer - Self (as James 'Blood' Ulmer)
- Beck - Self
- Nick Cave - Self
- Dick Waterman - Self
- Dick Waterman - Self - Son House's manager
- Eagle-Eye Cherry - Self
- Shemekia Copeland - Self
- Laurence Fishburne - Self - Narrator
- Skip James - Self (archive footage)
- Garland Jeffreys - Self
- J.B. Lenoir - Self (archive footage)
- John Mayall - Self (archive footage)
- Bonnie Raitt - Self
- Lou Reed - Self
- Vernon Reid - Self
- Marc Ribot - Self
- Steve Seaberg - Self
- Lucinda Williams - Self
- Cassandra Wilson - Self
- Marshall Chess - Self
- Chuck D - Self
- Elizabeth Cotten - Self (archive footage)
Laurence Fishburne interpreta a Self - Narrator en la serie.
Chris Thomas King hace el papel de Blind Willie Johnson.
Capítulo disponible en las siguientes plataformas:
