- Joseph Campanella - Lew Wickersham
- Gloria DeHaven - Gloria Farnsworth
- Paul Stewart - Dr. Halder
- Elisabeth Fraser - Beverly Renick Cortina
- Lloyd Nolan - Sam Dubrio
- Robert Middleton - Jake Coryell
- Brooke Bundy - Jill Bonnett
- Rip Torn - Victor Roarke
- Jack Bannon - Troy
- Tol Avery - Slade
- Henry Calvin - Lazaro Figueroa
- Linda Marsh - Irina Stassos
- Mako - Tami Okada
- Frank Puglia - Grandfather Bertelli
- Richard Mulligan - Dr. Bob Adams
- Diana Hyland - Janice Graham
- Ford Rainey - Dr. Crow
- John Randolph - Clint Houston
- Herbie Faye - Hustler
- Larry Pennell - Agent Barnes
- Sid Haig - Harry Kellaway
- Eddie Egan - Lt. Paul Haber
- Frank Aletter - Lorne Marshall
- Barbara Anderson - Angela Dubrio
- Dean Stockwell - Chris Townsend
- Paul Fix - Johnny Gundersen
- Donnelly Rhodes - Ramon Verona
- Neil Diamond - Neil Diamond
- Tom Skerritt - Morgan Carpenter
- Don Knight - Paul Gantry / Patrick Gray
- Jo Van Fleet - Alexandra Pulvarenti
- Pat Priest - Louise Carter
- Bruce Gordon - Bishop
- Robert H. Harris - J. P. Malloy
- Jerry Douglas - Lt. Mitch Webster
- Kim Hunter - Louise Dubrio
- Logan Ramsey - Gilbert Aumont
- Henry Beckman - Leonard Duncan
- Harold Gould - Bruno Raphael
- Steve Ihnat - Sheriff Weed
- Marion Ross - Muriel Enright
- Leslie Parrish - Linda Marley
- Vic Perrin - Tony
- Anthony Eisley - Lawrence King
- John Marley - Ernst Stassos
- Barbara Bosson - Miss Riley
- Stuart Nisbet - Tom West
- Gene Raymond - Richmond Greene
- Rosemary Forsyth - Liz Farrell
- William Smithers - Salvatore Pucci
- Judi Meredith - Carrie Day
- Booth Colman - Max Bonnett
- Alexander Scourby - Count Boria
- Glenn R. Wilder - McNeil
- Anthony Zerbe - James Conway
- Yvonne Craig - Mrs. Diana Everett
- Liam Dunn - Brock
- Norman Alden - Travers
- Robert Ito - Dr. Yoshiro
- Ed Lauter - Sergeant
- Robert Donner - Rizo
- Elsa Lanchester - Portia Penhaven
- Paul Picerni - Roger Stack
- Jessica Walter - Althea Blake
- Phil Leeds - Professor Wilson
- Phillip Pine - William Larkin
- Marlyn Mason - Joyce Loman
- Vincent Gardenia - Eddie Cortina
- Walter Baldwin - Luther
- Vera Miles - Jean McBride
- David Hurst - Vladek
- Robert Karnes - Walter Drake
- Henry Wills - Man with Sunglasses
- John Colicos - Eddie Lee Prentiss
- John Colicos - Dr. Myles Considine
- Joseph V. Perry - Police Officer
- Jon Cypher - Phillip Lomax
- Stanley Adams - Chip
- Jeanette Nolan - Granny Nell Foster
- Tim O'Connor - Albert Tucker
- Chick Chandler - Antrim Scott
- Dabney Coleman - Ralph Stoner
- Percy Rodriguez - Roy Bradley
- Michael Stanwood - Ken
- Joan Hotchkis - Irene Gifford
- Marc Lawrence - Angelo Palerma
- Paul Richards - Bradley Everett
- Ina Balin - Andrea
- Diane McBain - Stella Diamond
- Ric Roman - Frankie Saunders
- Herb Voland - Frank Terrano
- Charles Drake - Adam Pierson
- Quinn K. Redeker - Jim Dancy
- Richard Derr - Victor Farnsworth
- Richard Derr - Roger Kittridge
- James Olson - Donald Jordan
- Dana Elcar - Skip Seldon
- Robert Lansing - George Edward Diamond
- Joseph Mell - Landlord
- Jay Novello - Tomas Crespi
- Jay Novello - Rico Pucci Sr.
- Victor French - Matt Brandon
- Barbara Babcock - Nurse Hapgood
- Robert Yuro - Mike DiAngelo
- Larry Linville - Lieutenant George Kramer
- Max Kleven - Chauffeur
- Marian McCargo - Martha Pierson
- William Windom - Calvin Norris
- Lynn Hamilton - Eve Chancellor
- Peter Brandon - Mitch
- Hal Baylor - Henry Marshak
- Paul Mantee - Tommy Gantt
- Paul Mantee - Frank Viola
- Paul Mantee - Paul
- Paul Mantee - Marcos
- Arthur Franz - Father Vale
- Judith McConnell - J.C. Casey
- Ann Prentiss - Gwen Rogers
- John Doucette - Ward Gillis
- Dennis Patrick - Darrell Bigelow
- Woodrow Parfrey - Harry
- Woodrow Parfrey - Willie Small
- Sally Kellerman - Diana Walker
- Elena Verdugo - Eva Brock
- John Pickard - Trooper
- John Pickard - Wilkens
- Tom Stern - Lee Traherne
- Helen Funai - Joy Suk
- Geraldine Wall - Norma
- Lily Valenty - Maria
- Sharon Hugueny - Janet Malone
- Bobby Hall - Artie
- Dick Ziker - Bus Driver
- Dick Ziker - Mannix Imposter
- Bob Garrett - Chauffeur
- K.L. Smith - Sheriff Bevan
- Wende Wagner - Miss Ellis
- Gene Rutherford - Owney
- Leonard Yorr - Max
- Karla Most - Clara Warner
- Ramon Bieri - Peters
- Alan Caillou - Derek
- Gabriel Curtiz - Wiem
- Ben Cooper - Frank
- Edwin Max - Charley
- Norbert Schiller - Rolf Passauer
- Kenneth Mars - Mercer
- Letícia Román - Stella Scott
- Gerald York - Pete Cleary
- Marianna Hill - Ellen Barton
- Morgan Jones - Pender
- Morgan Jones - Howard Pender
- Jon Kowal - Guard
- Shepherd Sanders - Leonardo
- Lillian Adams - Woman
- Billy Snyder - Sergeant
- Jewell Lain - Jane
- Valora Noland - Cindy Gier
- Sherwood Price - Tony Lupcio
- Robert Emhardt - Ralph Warden
- Hugh Beaumont - Frank Abbott
- Hugh Beaumont - Hammond
- Ed McCready - Andy
- Allen Jaffe - Waiter
- Leonard Bremen - Charley
- John Harding - Rick Day
- Martin Braddock - Gordon Parker
- Jimmy Joyce - Manager
- Don Ross - 2nd Thug
- Sandra Smith - Violet Brooks
- Kevin Hagen - Alan Guthrie
- Kevin Hagen - Jackson
- Edna Glover - Operator
- Ken Renard - Mr. Sureyano
- Philip Vandervort - Hamilton
- Richard Bull - Dr. Lambert Whitaker
- Richard Bull - Professor Edmund Crewson
- Richard Bull - Dr. Green (uncredited)
- Richard Bull - Frank Devereaux
- Betty Anne Rees - Cora Hayden
- Tina Andrews - Edna
- Art Lewis - Hayden
- Jonathan Kidd - Target Range Operator
- Susan Howard - Amanda Hewitt
- Susan Howard - Christina Preston
- David Sheiner - Sam Duck
- Joe Maross - Dr. Steven Warren
- Joe Maross - Ira Welch
- Maggie Johnson - Sarah Toller
- Ed Bernard - Bull Evans
- Don 'Red' Barry - Mr. Barlow
- Weston Gavin - Rico Pucci Jr.
- Brenda Scott - Sandy
- Roy Engel - Stanley Blake (uncredited)
- Bob Herron - Thug #2 (uncredited)
- Harry Harvey - Proprietor
- Harry Harvey - Maintenance Man
- Harry Harvey - Doctor
- Harry Harvey - Garrison
- Harry Harvey - Ken Bailey
- Harry Harvey - Geologist
- Paul Stevens - Mayor Glass
- Paul Stevens - Vernon Olson
- Richard Bakalyan - Frank Quigley
- Richard Bakalyan - Vincent's Thug
- Dale Van Sickel - Bulldozer Driver (uncredited)
- Barbara Baldavin - Kay Kilgore (Imposter)
- Barbara Baldavin - Arleen Cade
- Clu Gulager - Lyle Foster
- Tom Hallick - Detective Lou Gifford
- Rory Calhoun - Al Ramon
- Richard Evans - Victor Valdek
- Victor Izay - Dr. Thackery
- Victor Izay - Room Service Waiter
- Victor Izay - Perry Christopher
- Robert Loggia - Inspector Varga
- Titos Vandis - Mayor
- Craig Littler - Jerry Smith
- Dabbs Greer - Dan Turpin
- Dabbs Greer - Petey O'Grady (uncredited)
- Emily Banks - Barbara West
- Emily Banks - Alyce Taggart
- Alfred Shelly - Cop (uncredited)
- Bill Quinn - Coroner
- Bill Quinn - Doctor
- Naomi Stevens - Woman with Figueroa (uncredited)
- Alan Fudge - Dr. Collins
- Bartlett Robinson - Alfred Price
- Joe Lo Presti - Captain Gomez
- Lee Meriwether - Reva Daniels
- Jeremy Slate - Ted Kilgore
- Nita Talbot - Gloria Turnbull
- Adam Williams - George Henderson
- Adam Williams - Prosecutor
- Natalie Schafer - Bunny Mason
- Marta Kristen - Aileen
- Belinda Montgomery - Susan Graham
- Del Monroe - Ramsey Tate
- Arch Whiting - Paul Emmons
- Dick Miller - Photographer
- Dick Miller - Fashion Photographer (uncredited)
- John Indrisano - Tim
- Jill Ireland - Ellen Kovak
- Joe Mantell - Albie Loos
- Joe Mantell - Eddie Stacy
- Nicholas Colasanto - Mac Wagner
- Madlyn Rhue - Marcia Inman
- Madlyn Rhue - Nedda Kordic
- Jed Allan - Ed Kovak
- Sue Ane Langdon - Mrs. Devereaux
- Robert Casper - Decorator
- Jack Ging - Lt. Dan Ives
- Jack Ging - James Spencer
- Russ Conway - Captain Briskin
- Russ Conway - H. T. Stewart
- Jan Sterling - Anne Marion
- Marian Seldes - Ida Colby
- Dick Cherney - Gardener (uncredited)
- Chuck Hicks - Deputy (uncredited)
- Chuck Hicks - Sikes
- Douglas Henderson - Tom Lockwood
- Douglas Henderson - Police Detective (uncredited)
- Douglas Henderson - Philip Crane
- Douglas Henderson - Simms
- Douglas Henderson - Thomas Ferguson
- Robert "Buzz" Henry - Helicopter Pilot
- Robert "Buzz" Henry - Fred
- George Sawaya - Safecracker (uncredited)
- George Sawaya - Lew
- George Sawaya - Driver (uncredited)
- Vic Morrow - Eric Latimer
- Mike Mazurki - Kony
- Geoffrey Lewis - Ernest
- Geoffrey Lewis - Killer
- Ron Nyman - Church Janitor (uncredited)
- Ron Nyman - Detective
- Ron Nyman - Policeman
- Ron Nyman - Deputy (uncredited)
- Ron Nyman - Police Officer (uncredited)
- Ron Nyman - Tony Lucio's Henchman (uncredited)
- Ron Nyman - Officer
- Ron Nyman - Sgt. Charley (uncredited)
- Ron Nyman - Sgt. Charlie
- Len Wayland - Chief Wedlow
- Len Wayland - Jake Durian
- Len Wayland - Jonathan Morrison
- Len Wayland - Pete (uncredited)
- Janis Paige - Georgia Durian
- George Murdock - Mr. Ferraro
- Buddy Joe Hooker - Rowdy (uncredited)
- Timothy Scott - Walter
- Kenneth Tobey - Sheriff
- Kenneth Tobey - Ted Bailey
- Kenneth Tobey - Sheriff Wells
- Veronica Cartwright - Mrs. Goldberg (uncredited)
- Fritz Weaver - Dr. Cameron McKenzie
- Fritz Weaver - William Avery
- Anne Archer - Anne Avery
- Guy Way - Party Guest (uncredited)
- Guy Way - Thug (uncredited)
- Guy Way - Man at Bar (uncredited)
- John S. Ragin - Burns
- Miko Mayama - Midori Nakano
- Bill Zuckert - Car Dispatcher - Eddie
- James B. Sikking - Sketchley
- James B. Sikking - Mark Langdon
- Robert Sorrells - Clement North
- Forrest Compton - Elgin Bonning
- Charles Dierkop - Frank Gillis
- Charles Dierkop - Makuta / John Marrish
- Bobby Troup - Bobby
- Bobby Troup - Bobby Troup
- Dorothy Neumann - Scrubwoman
- Dorothy Neumann - Gertrude
- Abe Vigoda - Anton Valine
- Harry Caesar - Inmate
- Edd Byrnes - Clay
- Harold J. Stone - Judge Green
- Ryan MacDonald - Lt. Robert Hargrave
- James McEachin - Benjy (uncredited)
- Don Eitner - Stu Marshall
- Don Eitner - Larry Scott
- Peter Mamakos - Smith
- Vince Howard - Doctor
- Vince Howard - Dr. Jackson
- J. Pat O'Malley - Mr. Bryant
- J. Pat O'Malley - Bartender
- J. Pat O'Malley - Lou Weldman
- Val Bisoglio - Charlie Larrabee
- Charlie Picerni - Ed Plummer (uncredited)
- Charlie Picerni - Cease (uncredited)
- Charlie Picerni - Kenneth (uncredited)
- Charlie Picerni - Danny Constantine
- Charlie Picerni - Larry Gates
- Gary Dubin - Mark
- Mark Russell - Orderly (uncredited)
- Mark Russell - Plainclothesman (uncredited)
- George Dunn - Customer
- Linden Chiles - Homer Boswell
- Lloyd Gough - Senator Miniver
- Madge Blake - Mrs. Muriel Pochek (uncredited)
- George Cisar - Hotel Clerk (uncredited)
- Jack Perkins - Henry (uncredited)
- Craig Chudy - Thug (uncredited)
- Craig Chudy - Martone
- Craig Chudy - Volleyball Player
- Craig Chudy - Marv
- Jonathan Goldsmith - Thomas Clayton Hewitt
- Jonathan Goldsmith - Lee Thomas
- Ross Hagen - Croaker
- Warren Vanders - Mel
- Barbara Rush - Rebekah Bigelow
- Barbara Rush - Celia Bell
- Clifton James - Barney Ford, Police Chief
- Joe E. Tata - Fred Eby
- Joe E. Tata - Gas Station Attendant
- Joe E. Tata - Augie
- Carmen Zapata - Chambermaid
- Lewis Charles - Dondero
- Peter Brocco - Derelict
- Peter Brocco - Don Vincent Demorra
- Peter Brocco - C.W. Taggart
- Mike Farrell - Clay Riegles
- Charles Napier - Police Officer (uncredited)
- Nick Dimitri - Soldier (uncredited)
- Charles Seel - Blind Man
- Robert Patten - Ben Lorenz
- Kathryn Hays - Betsy Charnik
- Bob Harks - Hood (uncredited)
- Bob Harks - Bomb Disposal Officer (uncredited)
- Bob Harks - Guard (uncredited)
- George Savalas - Sergeant
- Ted White - Thug (uncredited)
- Ron Masak - Barry Gates (uncredited)
- Adam West - Jonathan Forsythe
- Nehemiah Persoff - Anton Wojeska
- Elizabeth MacRae - Diane Glover
- Ed Call - Bernie Moss
- Pitt Herbert - Salesman
- Lee Miller - Neo James (uncredited)
- Elizabeth Ashley - Karen Winslow
- William Devane - Al Kordic
- Paul Shenar - Johnny Sands
- John Devlin - Rickard
- Ward Wood - Art Malcolm
- Herman Poppe - Ambulance Technician
- Anne Newman Bacal - Nurse
- Fred Krone - Hart (uncredited)
- Larry Watson - Lou (uncredited)
- Lucille Benson - Ida
- Lucille Benson - Myra
- Darrell Zwerling - Richard
- Richard Davalos - Paddy Wright
- Harry Carey, Jr. - Floyd Brand
- Don DeFore - Ted Hackett
- Reva Rose - Woman in Apartment
- Joshua Bryant - Paul Russell
- Oliver McGowan - Carl Dorso
- Stanja Lowe - Miss Landon
- John Aprea - Thug (uncredited)
- Vince Deadrick Sr. - Thug (uncredited)
- Rex Holman - Angel
- Ivor Barry - Duke of Wallingford
- Troy Melton - Harvey Grant
- Joby Baker - Rudy Marin
- Joseph Hindy - Gilbert Kordic
- John McLiam - Harry Forrest
- Erik Estrada - Tropic
- Stafford Repp - Fred Dobie
- Carol Lynley - Dorothy Kinman
- Lincoln Kilpatrick - Lonnie
- Alex Henteloff - Chili Dog
- Ray Ballard - Kobin
- Ray Ballard - Taxi Driver
- Milt Kogan - Les
- Darren McGavin - Mark
- Read Morgan - Ben Kessler
- Read Morgan - Policeman at cabin
- Greg Morris - Luke Whitney
- Ted Hartley - Don Elliott
- Ivan Goff
- Ben Roberts
- Bruce Geller
Naomi Stevens hace el papel de Woman with Figueroa (uncredited).
Abe Vigoda interpreta a Anton Valine en la serie.
George Murdock interpreta a Mr. Ferraro en la serie.
Tom Skerritt interpreta a Morgan Carpenter en la serie.
Marc Lawrence interpreta a Angelo Palerma en la serie.
John Marley interpreta a Ernst Stassos en la serie.
Adam Williams interpreta a George Henderson en la serie.
Phil Leeds hace el papel de Professor Wilson.
Elsa Lanchester interpreta a Portia Penhaven en la serie.
Robert Loggia interpreta a Inspector Varga en la serie.
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