- Ness Bautista - Joe Holliwell
- Lynn Collins - Natalie
- Gethin Anthony - Jack Brennan
- Brían F. O'Byrne - Frank McAlpine
- Kelly Jenrette - Stacey Knox
- Judith Light - Bobi Jewell
- Joe Fishel - FBI Agent
- Grady Port - Young Ted
- Tyler Huth - Timmy Oakes
- Justin Matthew Smith - Gil Murray
- Maia Moss-Fife - Gil's Secretary
- Kyle Beatty - Alan Meeks
- Evan Henderson - SF Chronicle Mailboy
- Tom Thon - Political Science Professor
- Frank Brennan - History of Science Professor
- Wilbur Fitzgerald - UCSB Professor
- Lindsay Ayliffe - Hard Science Professor
- Michael Nouri - Bob Guccione
- Wallace Langham - Louis Freeh
- Jane Lynch - Janet Reno
- Griff Furst - Burkhardt
- Rhoda Griffis - Beth Ackerman
- Liam Day - Suspicious UnSub
- Maureen Mountcastle - Janet Reno's Secretary
- Will Murden - Sean Fitzgerald
- Banks Repeta - Dan Fitzgerald
- Brian d'Arcy James - Professor Henry Murray
- Trieste Kelly Dunn - Theresa Oakes
- Johnny Berchtold - Teenage Ted
- Simone Lockhart - Pretty Girl
- Alan D'Antoni - Mailman
- Bernard Hocke - Dark Scientist 1
- Myke Holmes - Dark Scientist 2
- Michael Harrity - G-Man
- Diesel Madkins - Ernie Esposito
- Elizabeth Becka - Sandy
- Melisa Cardona - Ackerman's Secretary
- John Wilmot - Judge Lovell
- Leon Farmer - Swat Leader
- Curtis Wyatt III - FBI Agent 1
- David Jensen - Jerry Burns
- Tom Nowicki - Tom McDaniel
- Katja Herbers - Linda Patrik
- Christian Camargo - Lowell Bergman
- Rebecca Henderson - Judy Clarke
- Mike Pniewski - Dr. Charles Epstein
- Gregory Alan Williams - Judge Garland Burrell
- Dan Triandiflou - Gary Wright
- Doug Kruse - David Gelernter
- Jana Allen - Heidi Shumway
- Mary Rachel Dudley - Lois Epstein
- Steve Coulter - Anthony Bisceglie
- Bonnie Johnson - Wanda Kaczynski
- Joe Knezevich - Steve Freccero
- Pamela Ricardo - Court Clerk
- Candace Mabry - Patrick Fisher's Secretary
- Rowan Bousaid - Yuppy Dad (Birdwatcher)
- Alex Webb - FBI Forensic Lead
- Tonya Bludsworth - Yuppy Mom (Birdwatcher)
- Jill Remez - Susan Mosser
- Monique Yvette Grant - Alice Hawthorne
- Ricky Wayne - Mayor Campbell's Aide
- Andrew Sensenig - Piedmont College President
- Kent Shocknek - News Anchor
- Barry Ratcliffe - Clairemont Hills Pastor
- Wes Jetton - ATF Bomb Tech
- Christopher Beanland - FBI Forensic Agent
- Cindy Fernandez-Nixon - CNN PA
- Bryan Fitzgerald - Frat Bro
- Jarrod Beck - Hooligan
- Adam Ratcliffe - Georgia State Trooper
- Soleil Patterson - Fallon Stubbs
- Jason Turner - APD Colonel
- Cabot Rea - News Anchor
- Bill Dawes - Cadigan
- Jay DeVon Johnson - ATF Chief
- Cornelius Smith, Jr. - Mayor Bill Campbell
- Marley Shelton - Hannah Gray
- Roxanne Hart - Trudy Embry
- Desmond Harrington - FBI Head Louis Freeh
- Keisha Castle-Hughes - Tabby
- Elizabeth Reaser - Ellie Fitzgerald
- Mark Duplass - David Kaczynski
- Nick Searcy - Sheriff Thompson
- Brad William Henke - Big John
- Tony DeMil - Charlie Cooke
- Jay O. Sanders - Jack Bryant
- Patrick Cage - Jermaine Hughes
- Malerie Grady - Lindsay
- Tony Wade - Lead Agent
- Nick Towne
Cameron Britton interpreta a Richard Jewell en la serie.
Carla Gugino hace el papel de Kathy Scruggs.
Jack Huston hace el papel de Eric Rudolph.
Arliss Howard interpreta a Earl Embry en la serie.
Ness Bautista hace el papel de Joe Holliwell.
Gethin Anthony hace el papel de Jack Brennan.
Kelly Jenrette interpreta a Stacey Knox en la serie.
Judith Light interpreta a Bobi Jewell en la serie.
Joe Fishel interpreta a FBI Agent en la serie.
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