- Alexia Fast - Callie Winter
- William Petersen - Col. Emmett Darrow
- Jason Weiler - Finney
- Jason Weiler - Scientist #2 / Finney
- Shylo Molina - Featured Child
- Vic Browder - Deputy
- Mona Malec - Secretary
- Fran Martone - Akley's Secretary
- Colin Jones - MP2
- Colin Jones - Wayne
- Kristen Rakes - Wilma
- Mark Sivertsen - Staff Sergeant
- Debrianna Mansini - Dorothy
- Ben Ziegler - Hankins
- Vivian Nesbitt - Colonel Cox's Assistant
- Sarah Minnich - Vera
- Kent Kirkpatrick - Army Doctor
- Kent Kirkpatrick - Doctor
- John Trejo - Zeller
- Nate Warren - Vidders
- Christian Clemenson - Niels Bohr
- Philip Ettinger - Watts
- Beth Bailey - Fay
- Rebekah Wiggins - Gladys
- David Midthunder - Aniceto
- Kevin Wiggins - Field Sergeant
- Dave Racki - Soldier #1
- Bryan Head - Soldier #2
- Trine Christensen - Nurse
- Kyle T. Cowan - Young Frank
- Glenn Morshower - Censorship Captain
- Nathaniel Augustson - Bruce
- Nathaniel Augustson - Soldier
- Tommy Truex - Young Officer
- Kenneth Miller - Purcell
- Kenneth Miller - Purcell / MP1
- Genia Michaela - Ruth
- Katie Anne Mitchell - Ticketing Agent
- Joshua Rollins - Tuck
- Frank Bond - Tupper
- John Carroll Lynch - Daniel Ellis
- John Gabriel Rodriquez - Travis
- Matthew Page - Weaver
- Matthew Page - Edgar
- Jessica Hecht - Miriam Rubins
- Robin Thomas - Maxwell Rubins
- Kristin Hansen - Akley's Secretary
- Mark Moses - Col. Alden Cox
- Josh Cooke - Lancefield
- Josh Cooke - Tom Lancefield
- Lucia Micarelli - Annie Liao
- Carole Weyers - Elodie
- Carole Weyers - Elodie Lancefield
- Jade Scott Lewis - Swee
- David Harbour - Reed Akley
- Tailinh Agoyo - Paloma
- Paul Blott - Church
- Bruce McIntosh - Samaritan
- Tad Jones - Major Pelligrin
- Tad Jones - Brass
- Tad Jones - Major Pellegrin
- Adam Godley - Dr. Adelman
- Raoul Max Trujillo - Javier
- Lora Martinez-Cunningham - Ida
- Jennifer Allcott - Evelyn
- Jefferson White - Cole 'Iowa' Dunlavey
- Jefferson White - Cole
- Eddie Shin - Sid Liao
- Christina Kirk - Rose Akley
- James Lawrence Sicard - Ivan
- Gerald McRaney - Sec. Hentry Stimson
- Ryan Jason Cook - Stanhope
- Jonny Coyne - Dr. Alek Barath
- Michael O'Neill - Psychiatrist
- Fiona Dourif - Jean Tatlock
- Fiona Dourif - Jean Tatlock (voice)
- Travis Hammer - O'Byrne
- Neve Campbell - Kitty Oppenheimer
- Tony Devon - Omar
- Joanne Camp - Oppenheimer's Secretary
- Jessica Osbourne - Constance Faraday
- Jessica Osbourne - Constance
- Richard Schiff - Occam
- Catherine Haun - Dot
- Brad Garrett - Eli Isaacs
- Bill Camp - William Hogarth
- Daniel London - J. Robert Oppenheimer
- Stafford Douglas - Thatcher
- Corey Allen - Theodore Sinclair
- Audrey Moore - Francine
- Peter Stormare - Lazar
- Griffin Dunne - Woodrow Lorentzen
- Justin Kirk - Joseph Bucher
- Mamie Gummer - Nora
- Jason Ralph - Stan
- Danny Winn - Scientist Brock
- Lauren Chavez-Myers - Jeannie
- Kiira Arai
- Zoe Keating
- Jeff Russo
Brad Garrett hace el papel de Eli Isaacs.
Peter Stormare interpreta a Lazar en la serie.
John Carroll Lynch interpreta a Daniel Ellis en la serie.
Griffin Dunne interpreta a Woodrow Lorentzen en la serie.
John Benjamin Hickey interpreta a Frank Winter en la serie.
Olivia Williams interpreta a Liza Winter en la serie.
Ashley Zukerman hace el papel de Charlie Isaacs.
Rachel Brosnahan interpreta a Abby Isaacs en la serie.
Harry Lloyd hace el papel de Paul Crosley.
Katja Herbers interpreta a Helen Prins en la serie.
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