- Sicily Johnson - Diana (Teenager)
- Novella Nelson - Pearl (1955-1970)
- Elijah Kelley - Young Willie
- Tommy Hollis - Reverend Jackson
- David Ramsey - Booker Palmer (Adult)
- Donna Biscoe - Jessica
- Rhoda Griffis - Mrs. Hopkins (Younger Woman)
- Edith Ivey - Mrs. Hopkins (Older Woman)
- Shashawnee Hall - Ab
- Terrence Howard - Lincoln
- E. Roger Mitchell - Charlie (1912)
- Ronald McCall - Johnny Metzer
- Gregory Alan Williams - Charlie (1941)
- DJ Qualls - Jason
- Faye Yvette McQueen - Dancer
- Earl Maddox - Racist
- Wilbur Fitzgerald - Public Defender
- Jill Jane Clements - Waitress
- Angela Elayne Gibbs - Woman with Baby
- Libby Whittemore - Nurse
- Don Henderson Baker - Clerk (1955)
- Tony Vaughn - Man (1941)
- Jody Thompson - Another Boy
- Alex Van - Ralph
- Frank Hoyt Taylor - Mr. Anderson
- Wynton Yates - Don
- Patty Mack - Pearl
- Michelle Benjamin Cooper - Pearl
- Wesley Yates - Booker Palmer (Age 8)
- Preston Wigasi Brant - Booker Palmer
- Mike Masters - Ben
- Angelina Spicer - Ruthana (Teenager)
- Carol Mitchell-Leon - Flora's Mama
- Tom Even - Judge Bennett
- Mitchell Laurance - State's Attorney
- Tonea Stewart - Bessie
- Tina King - House Maid
- Jevon Dewand - Slave
- Carrie Collins - Bar Patron
- Joe Cobb Jr. - Dock Worker #2
- Scott Oliver - Judge Hogan
- James Mayberry - Blood Donor #1
- Mert Hatfield - Sheriff
- Erik Kilpatrick - Reggie
- Jordan Williams - Kevin Hopkins (Older Man)
- Jonathan Parks Jordan - Gavin Hopkins
- Crystal R. Fox - Ruthana
- Jermaine Jackson - Dancer
- Peter Werner
- Alex Haley
- Carol Schreder
- David Stevens
Cicely Tyson interpreta a Mama Flora en la serie.
Erika Alexander interpreta a Young Flora en la serie.
Blair Underwood interpreta a Willie en la serie.
Queen Latifah hace el papel de Diana.
Mario Van Peebles hace el papel de Luke.
Hill Harper interpreta a Don en la serie.
Shemar Moore interpreta a Lincoln Fleming en la serie.
Lou Myers interpreta a Albie en la serie.
Tanya Wright hace el papel de Ernestine.
Sicily Johnson interpreta a Diana (Teenager) en la serie.
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