- Nadine Velazquez - D.D.A. Emma Rios
- Robert Gossett - Assistant Chief Taylor
- Carlos Ponce - Mr. Emilio Diaz
- Leslie Grossman - Claire Hunter
- Caitlin Custer - Raquel Newman
- Amy Davidson - Allison fisher
- Ransford Doherty - Kendall
- Jason London - Chris Harris
- Shanna Collins - Robyn Harris
- Devon Werkheiser - Officer Cooper
- Rick Peters - Michael Harris
- Justin Schollard - Dr. Newman
- Ross Butler - Ian Yorita
- Bill Brochtrup - Dr. Joe Bowman
- Kathe Mazur - D.D.A. Andrea Hobbs
- Markus Flanagan - Dr. Carl Riley
- Clare Carey - Mrs. Riley
- Molly Burnett - Kim Riley
- John Lacy - Jimmy Bosch
- Jeanine Mason - Heather
- Esai Morales - Deputy Manuel Diaz
- Christopher Cousins - Dr. Charles Mason
- Jessica Lundy - Aubrey Dietz
- Amir Talai - Geoff Klein
- Kevin Shinick - Barry Lawrence
- Joe Flanigan - Rick Marlow
- Rebecca Wisocky - Madeline Morgan
- David Mazouz - Steve
- Will Shadley - Mike
- Gavin Stenhouse - Jason Dietz
- Daniel Reichert - Mr. Downy / Luke Dalton
- Noah Weisberg - Roland Jennings
- Thad Luckinbill - Hunt Massey
- Jansen Panettiere - Reed Downy / Rory Brooks
- John D'Aquino - Craig Fowler
- Peter Katona - Alex Bennett
- Jon Tenney - Agent Fritz Howard
- Michael Nouri - Congressman Steven Keller
- Devon Graye - Ryan Keller
- Scott Bailey - Robert Keller
- Michael Hyatt - Jada Roads
- Josh Randall - Detective Sean Mackeroy
- Yaani King Mondschein - Mrs. Walker
- Jakobe Dempsey - Darryl Walker
- Jermel Howard - Miller
- Darrell Britt-Gibson - Shorty Wallace
- Alani iLongwe - T-Ray Jackson
- Eugene Shaw - Ben Wells
- Jared Hillman - Jason Grant
- Malcolm-Jamal Warner - Lt. Chuck Cooper
- Dan Castellaneta - Ray Winters
- John Aylward - Ted King Sr.
- James MacDonald - Lt. Reed
- Joel Brooks - Gary Bridges
- Nic Robuck - Darren Talbot
- Molly Stanton - Olivia King
- Teresa Ruiz - Monica Garcia
- Augustus Prew - Billy
- Augustus Prew - Wade Weller aka Ryan Mills
- Carlos Moreno Jr. - Florentino Reyes
- Chris Trouble Delfosse - Jesus Chavez
- Jeri Ryan - Linda Rothman
- Sydney Walsh - Susan Mills
- Nathan Kress - Tyler Lang
- Jim Beaver - Donald Beckwith
- Tom Parker - Ted King Jr.
- Chris Wood - Brandon North
- Sonya Leslie - Cynthia
- Amir Malaklou - NEMO BEHDI
- John Ales - Martin Elliot
- Richie Stephens - Marcus Kemp
- Susan Grace - Mark's Grandma
- Xolo Mariduena - Stefan Camacho
- Jesse McCartney - Dawson Tucker Yale
- Adam Irigoyen - Jesus Marquez
- Matt O'Leary - Alex Wilson
- Jason Dolley - James Martin Elliott aka 'J-Me'
- Nikki DeLoach - Corporal Laura Day
- Reiley McClendon - Benny
- Kate Morgan Chadwick - Katherine 'Kiki' Weinberger
- Anthony Keyvan - Lucas Garza
- Susan James Berger - Mary Conrad
- Pamela Dunlap - Lorraine North
- Alejandra Flores - Mrs. Herrera
- Noah Crawford - Connor Price
- Brian Borello - Chris Walker / Gold Storm
- Amy Bailey - Karina Volsky
- Diego Delpiano - Tim Greggs
- Bridger Zadina - Wyatt Duncan
- Zac Badasci - Cory
- Luke Cook - Joey Bowie
- Guy Wilson - Mark Howard
- Jaime Ray Newman - Wildred Darnell
- Torrey DeVitto - Nicole
- Nick E. Tarabay - Jason Goss
- Ron Marasco - Judge Grove
- Madison McLaughlin - Kris Slater
- Skye P. Marshall - Makisha Selby
- Lenny Jacobson - Erik Walsh
- Charlene Amoia - Kelly Press
- Shannon Dang - Sushi Hostess
- Ever Carradine - Sharon Beck
- Brooke Nevin - Mrs. Palmer
- Tamara Mello - Jordan Garcia
- Kenneth Mitchell - Sam Curtis
- Raoul Max Trujillo - Javier Mendoza
- Chris Browning - Mustache
- Brandon Barash - Detective Robby Oderno
- Chris Brochu - Josh Allen
- Rita Volk - Briana Mathis
- Conor Leslie - Mary Lowe
- Alyson Reed - Mrs. Lowe
- Tim Chiou - Ken Song
- Shelby Wulfert - Megan Cushing
- Alice Greczyn - Vanessa Blaine
- Rick Fox - Rick Fox
- Jon Wellner - Attorney
- Ian Bohen - Daniel Dunn
- Daniel Di Tomasso - Detective Wes Nolan
- Brey Chanadet - Young Michael (uncredited)
- Tanner Buchanan - Michelle Brand
- Rene Rosado - Gustavo "Gus" Wallace
- Leslie L. Miller - Rachel
- Stuart Ambrose - Uniformed Officer
- Carole Cook - Marcella Brewster
- Jon Polito - Dino Kotero
- America Olivo - Liseth Ortiz
- James Duff
- Sylvain White
- Anthony Hemingway
- Stacey K. Black
- Steve Robin
- Rick Wallace
- Ralph Gifford
- Carson Moore
- Michael Alaimo
- Jim Leonard
- Leo Geter
- Duppy Demetrius
- Greer Shephard
Jon Polito interpreta a Dino Kotero en la serie.
Dan Castellaneta interpreta a Ray Winters en la serie.
Augustus Prew interpreta a Billy en la serie.
Jon Tenney interpreta a Agent Fritz Howard en la serie.
Mary McDonnell interpreta a Captain Sharon Raydor en la serie.
G.W. Bailey hace el papel de Lt. Louie Provenza.
Tony Denison interpreta a Lt. Andy Flynn en la serie.
Michael Paul Chan hace el papel de Lt. Mike Tao.
Raymond Cruz interpreta a Detective Julio Sanchez en la serie.
Phillip P. Keene hace el papel de Buzz Watson.
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