- Jordan Peele - Various
- Pablo Francisco - Various
- David Herman - Various
- Ike Barinholtz - Various
- Debra Wilson - Various
- Bobby Lee - Various
- Phil LaMarr - Various
- Keegan-Michael Key - Various
- Michael McDonald - Various
- Will Sasso - Various
- Frank Caliendo - Various
- Andy Daly - Various
- Nelson Ascencio - Various
- Pat Kilbane - Various
- Ron Pederson - Various
- Stephnie Weir - Various
- Josh Meyers - Various
- Jill-Michele Meleán - Various
- Craig Anton - Various
- Crista Flanagan - Various
- Tim Conlon - Various
- Paul Vogt - Various
- Bryan Callen - Various
- Arden Myrin - Various
- Chris Hogan - Various
- Nicole Randall Johnson - Various
- Anjelah Johnson-Reyes - Various
- Frank Caeti - Various
- Johnny A. Sanchez - Various
- Kandice Stroh - Barbra Streisand (1 episode)
- Alex Borstein - Various
- Alex Borstein - Ms Swan / Karen
- Alex Borstein - Ms. Swan, Mama Brightling
- Orlando Jones - Various
- Orlando Jones - Self - Special Guest / Andre 3000
- Artie Lange - Various
- Artie Lange - Self - Special Guest
- Nicole Sullivan - Various
- Nicole Sullivan - Self
- Nicole Sullivan - Meg Ryan
- Nicole Sullivan - Lida
- Nicole Sullivan - Mindy Tikvah
- Andrew Bowen - Various
- Andrew Bowen - Star Trek-Encore (archive footage)
- Mark Hamill - Mr. Swan
- Stan Lee - Self
- Tommy Lee - Self
- Michael Buffer - Self
- Barry Williams - Self
- Dean Collins - Ernie
- Jessica Alba - Jessica Simpson
- Martin Short - Self
- Missy Elliott - Self
- Tony Hawk - Self
- Carmen Electra - Self - Guest Host
- Neve Campbell - Self - Host
- Billy Barty - Self
- Halle Berry - Self
- Tyra Banks - Katisha
- David Faustino - Self - Host
- Jay-Z - Self
- Vitamin C - Self
- Jennifer Lyons - Player
- John Mahoney - Self
- Kato Kaelin - Self
- Pauly Shore - Self - Host
- Pam Grier - Self - Guest Host
- Harry Connick Jr. - Self - Host
- Eve Plumb - Herself / Host
- Jay Roach - Self
- Cindy Margolis - Self - Special Guest
- Illeana Douglas - Self
- Leah Remini - Self
- Bobcat Goldthwait - Self - Host
- Ike Turner - Self
- RuPaul - Self
- Shaquille O'Neal - Self
- Jennette McCurdy - Cassidy Gifford
- Devon Alan - Little Boy
- Amanda Bynes - Self
- Colby Donaldson - Self
- Kate Walsh - Self - Special Guest
- Bruce McCulloch - Self
- Maile Flanagan - Chastity Bono (uncredited)
- David Boreanaz - Self
- Seth MacFarlane - Seth MacFarlane / Peter Griffin
- Fred Willard - Self - Special Guest / Gene St. John
- Lou Diamond Phillips - Self
- Keri Russell - Self
- Flea - Self
- Chris Kirkpatrick - Self
- Oprah Winfrey - Self
- Eliana Alexander - Maria
- Amanda Bearse - Self - Cameo (uncredited)
- Preston Lacy - Self
- Jim Meskimen - Neil
- Whoopi Goldberg - Self
- Wanya Morris - Self
- Countess Vaughn - Self
- Anna Faris - Self
- John Cena - Self
- Danny DeVito - Self
- Ryan Reynolds - Self
- Daisy Fuentes - Self
- Phyllis Diller - Self - Hostess
- Joe Walsh - Self
- Donny Osmond - Self
- Marc Anthony - Self
- Chris Klein - Self - Special Guest / Executive
- Xzibit - Self
- Isaac Mizrahi - Self
- Peter Werner - IZM Biker
- Chyna - Self
- Lennox Lewis - Self
- Brian McFayden - Self
- Steve-O - Self
- Cedric the Entertainer - Dr. Jekyll / Mr. Hyde
- Jamie Kennedy - Self
- Michael Rapaport - Abraham Lincoln
- Danny Bonaduce - Self
- La Toya Jackson - Self
- Anna Nicole Smith - Self - Cabana Chat guest
- Rip Taylor - Self
- Michelle Clunie - Heidi
- Trevor Einhorn - Brother
- Robert Englund - Self
- Alison Sweeney - Self
- Yasmine Hanani - Barkur's Beauty
- Ben McKenzie - Ryan Atwood
- Tony Danza - Self
- Cole Petersen - Trevor
- Jazzmun - Martina
- Tony Orlando - Self
- Brian Dunkleman - Self
- Aisha Tyler - Self
- Anthony Hamilton - Self
- Christina Milian - Self
- James Brown - Self
- Jeff Garlin - Hank Whitley
- Brian McKnight - Self
- Dweezil Zappa - German Tourist Tobias
- Ryan Stiles - Self - Host
- Bret Hart - Self
- Freddie Prinze Jr. - Self
- Michael Madsen - Self
- Tom Arnold - Self
- Shakira - Self
- Melina Kanakaredes - Self
- Carl Edwards - Self
- Christopher Meloni - Various
- French Stewart - Self - Host
- Queen Latifah - Self - Hostess
- Arjay Smith - Troy
- Bill O'Reilly - Self
- Debbie Harry - Self
- Bo Bice - Self
- Brandon Molale - Stone Cold Edie Austin
- David Anthony Higgins - Self
- Jordan Black - Self
- Michael Cera - Self
- Howie Mandel - Self
- Joe Rogan - Self - Host
- Thomas Calabro - Self - Host
- Rene Russo - Self
- Q-Tip - Self
- Joe Brown - Self
- Jada Pinkett Smith - Self
- Paul Lévesque - Triple H
- Freddy Rodríguez - Self
- Andrea Martin - Self - Hostess
- Steve Borden - Self
- Perez Hilton - Self - Host
- Vanessa Williams - Self
- Pamela Anderson - Various
- Michael McDonald - Various
- Ne-Yo - News Anchor
- Kevin McDonald - Self - Host
- Peter Dennis - Announcer
- Garry Marshall - Self
- Susan Sarandon - Self
- Susan Sarandon - Self - Special Guest
- Eddie Guerrero - Self
- Christopher Titus - Self - Special Guest
- Rob Corddry - Johnny
- Adam Copeland - Cornell Overstreet / Self
- Katie Cassidy - Self
- Brian Bosworth - Self
- Jean Speegle Howard - Elderly Woman
- LeVar Burton - Self
- John C. McGinley - Self - Special Guest / Paul a Postal Worker
- Dulé Hill - Self
- Murphy Lee - Self (uncredited)
- Mandy Moore - Self
- Erica Hubbard - Double Dutch Rope Jumper
- Eva Longoria - Self
- Chris Hardwick - Self
- Richard Schiff - Self
- Brittany Curran - Ruthie
- Kelly Preston - Self
- Matthew Broderick - Self
- Richard Lewis - Self
- Spencer Daniels - Skeeter
- Tom Bergeron - Self
- Tony Shalhoub - Taxi Cab Driver
- Tony Shalhoub - Self
- William H. Macy - Self
- Don Most - Don Most as Peter Pippen
- Jillian Warry Barberie - Mikayla
- Peter Marshall - Self
- Nelly - Self
- Desmond Llewelyn - Self
- Ann Walker - Teacher
- Melissa Joan Hart - Melissa Joan Hart / Britney Spears
- Venus Williams - Self
- Todd Bridges - Self
- Ray Allen - Self
- Sting - Self
- Dan Milano - Greg the Bunny
- Quincy Jones - Self
- Paul Wight - Self
- Catherine O'Hara - Woman on Blind Date
- Amanda Beard - Self
- Roddy Piper - Self
- Jay Mohr - Self / Chris Penn
- Tim Robbins - Self
- Sandra Bernhard - Self - Host
- Scott Wolf - Bailey Salinger
- Robert Zemeckis - Self
- Adam Brody - Seth Cohen
- Mary Elizabeth McGlynn - Interviewer
- Claudia Schiffer - Self
- Bob Newhart - Self - Special Guest
- Randy Jackson - Self
- Kelly Hu - Self
- Lisa Loeb - Singer in Hallway
- Nicole Richie - Self
- Nicole Richie - Self - Special Guest
- Tom Kenny - Self
- JC Chasez - Self
- Ahmet Zappa - Mr. Baun
- Cody Klop - Michael
- Cody Klop - Bratty Kid
- Ice-T - Self - Host
- Jon Heder - Self
- Jon Heder - Self - Special Guest / Percy
- Lawrence Mandley - Cameraman
- Brian Austin Green - White Chocolate
- Harland Williams - Self
- Jacklyn Zeman - Self
- Redman - Sam Boogie
- Terry Bradshaw - Self
- Christina Applegate - Self
- Roy Jones Jr. - Self
- Kevin Sorbo - Self
- Scott Adsit - Stagehand
- Lise Simms - Executive
- Jason Earles - Swirley Kid
- Bucky Lasek - Self
- Zack Shada - Crippled Boy
- Sandra 'Pepa' Denton - Self
- Regis Philbin - Self
- Alanis Morissette - Self
- Rodney Dangerfield - Self - Host
- Andy Dick - Self
- Keanu Reeves - Self
- Don Johnson - Self
- Dustin Hoffman - Self
- Steve Harvey - Self
- Martin Klebba - Rich
- Beverly Johnson - Self
- Patton Oswalt - Crip in Wheelchair
- Pierce Brosnan - Self
- Lee Reherman - Fist
- Kristin Davis - Self
- Oscar de la Hoya - Self
- Jacob Young - Self
- Jon Favreau - Self
- Tequan Richmond - Tyson
- Usher - Self
- Camryn Manheim - Self
- David James Elliott - Children's Book Author
- Sean Hayes - Self
- George Carlin - Self
- George Carlin - Mr. Conductor
- Jake Busey - Self
- Eric Idle - Zookeeper
- Sara Rue - The Babysitter
- Ron Howard - Self
- Ken Norton Jr. - Self
- Nathan Morris - Self
- Kelly Osbourne - Self
- Frankie Muniz - Self
- Frankie Muniz - Humorist (uncredited)
- LL Cool J - Self
- LL Cool J - Self - Host
- Matthew Fox - Charlie Salinger
- Soren Fulton - Birthday Boy
- Soren Fulton - Timmy
- Aaron Carter - Self
- Tom Green - Self
- Vivica A. Fox - Self
- Vivica A. Fox - Self - Special Guest
- Bobby Edner - Michael
- Bobby Edner - Robot Trick or Treater
- DMX - Self
- DMX - Self - Special Guest
- Gary Coleman - Self
- Dionne Warwick - Self
- Laurence Fishburne - Self
- Damon Dash - Self
- Ben Affleck - Self
- Jane Krakowski - Self
- Kenny G - Self
- Warren Beatty - Self
- David Arquette - Self
- David Arquette - Self - Special Guest / Stanley
- Will Smith - Self
- Charlton Heston - Self
- Bradley Whitford - Self
- William Hung - Self
- Patrick Fugit - Self
- Patrick Fugit - William Miller
- Dominic Monaghan - Self
- Jack Betts - Judge
- Elisha Cuthbert - Self
- Chingy - Self
- Chingy - Self - Musical Guest
- Ja Rule - Ja Rule
- Ja Rule - Self / Cousin Leo
- Ja Rule - Self
- Philip Bailey - Self
- Jeffrey Tambor - Self
- Kim Cattrall - Self
- Mathew St. Patrick - Self
- Brad Rowe - Self
- Kristin Chenoweth - Self
- Nick Cannon - Self
- Calista Flockhart - Self
- Tommy Davidson - Woogie Jones Johnson
- Tommy Davidson - Self - Host
- Toni Braxton - Self
- Jaclyn Smith - Jaclyn Smith
- Fred Durst - Self
- Mila Kunis - Daisy
- Taye Diggs - Self
- Ashley Edner - Jen (segment "Dawson's Crib")
- Ashley Edner - Princess Trick or Treater (segment "Halloween Runners")
- Ashley Edner - Stacy (segment "Ally McMeal")
- Ashley Edner - Jane (segment "Mary Poppins")
- Michael Michele - Self
- Cuba Gooding Jr. - Self
- Kevin Smith - Self - Special Guest / Captain Scurvy
- Method Man - Gentry Abrams
- Dakota Fanning - Self
- Wayne Brady - Self
- Michelle Trachtenberg - Self
- Don Cheadle - Perry
- Don Cheadle - Self
- Keely Shaye Smith - Self
- Justin Timberlake - Self
- Malinda Williams - Self
- Ken Jeong - Passenger
- Ken Jeong - Ken
- Ken Jeong - Sung Chul Yang
- Eric Benet - Self
- Lance Armstrong - Self
- Morgan Flynn - Girl Scout
- Terry Farrell - Self
- Daran Norris - Passerby
- Daran Norris - Waiter
- Essence Atkins - Self
- Michael Clarke Duncan - Self
- Drew Barrymore - Self
- Christine Lahti - Self
- Courteney Cox - Self
- Carson Daly - Self
- Snoop Dogg - Self
- Snoop Dogg - Back Doe Johnson
- Jeff Probst - Self
- Jeff Probst - Self - Host
- 'Weird Al' Yankovic - Self
- Shannon Elizabeth - Self
- Fran Drescher - Self
- Rob Thomas - Self
- Christina Aguilera - Self
- Alec Baldwin - Self
- Tara Reid - Self
- Hulk Hogan - Self
- Wanda Sykes - Self
- Portia de Rossi - Self
- Michelle Pfeiffer - Self
- Jack Osbourne - Self
- Lara Flynn Boyle - Self
- Simon Cowell - Self
- Bryan Cranston - Self / Mike
- Bryan Cranston - Self
- Spencer Breslin - Self
- Ted Danson - Self
- Gloria Estefan - Self
- John Cleese - Self
- Jackie Chan - Self
- Sheryl Crow - Self
- Patricia Heaton - Self
- Glenn Close - Self
- Jimmy Fallon - Self
- Nick Lachey - Self
- Jennifer Aniston - Self
- Shawn Wayans - Self
- Chris Isaak - Self
- Anthony Anderson - Self
- Dave Navarro - Self
- Evan Ellingson - Church Camp Boy
- Mark Curry - Self - Host
- Travis Van Winkle - Shirtless Hunk
- Aaron Coleman - Preacher
- Menina Fortunato - Dancer
- Menina Fortunato - Self
- Menina Fortunato - Cowgirl
- Smalls - Notorious B.I.G.
- Christopher Masterson - Lawyer
- Christopher Masterson - Humorist (uncredited)
- Hayley Erin - Dakota Fanning
- Hayley Erin - Tina
- Hayley Erin - Amy
- Hayley Erin - Nora
- Hayley Erin - Jamie
- Hayley Erin - Little Girl with Balloon
- Hayley Erin - Jenny
- Alanna Masterson - Daughter
- Casey Kasem - (voice: credit only)
- Megan Mullally - (uncredited)
- Debra Messing - (uncredited)
- Todd Giebenhain - Humorist (uncredited)
- Tania Raymonde - Little Daughter (uncredited)
- Twista - Self
- Ashley Greene - Amber
- Dylan Sprayberry - Tyler
- Mark Hoppus - Blink-182 Member
- Bret Michaels - Self
- Rikki Rockett - Self
- Bobby Dall - Self
- Blues Saraceno - Self
- Dean Stockwell - Self
- Adam West - Self
- Dana Gould - Self
- Jamie Farr - Self
- Dave Foley - Self
- Andy Kindler - Self
- Chris Ballew - Self
- Jason Finn - Self
- Tré Hardson - Self
- Romye Robinson - Self
- FatLip - Self
- Doug Llewelyn - Self
- Kim Coles - Self
- Kim Coles - Self - Host
- Jack Wagner - Self - Host
- Taylor Negron - Self
- Tony Cox - Self
- Dom Irrera - Self
- Phil Nichol - Self
- Seán Cullen - Self
- Adam Arkin - Self - Host
- Bob Marley - Self
- Jalen Rose - Self
- Steve Austin - Self
- Ed Marques - Osama Bin Laden's Neighbor
- Curt Clendenin - High School Wrestler (uncredited)
- Peter Sallis - Wallace (voice)
- Zaina Juliette - Dawn
- Zaina Juliette - Dawn
- Kim Kim - Mother
- Michelle Basterrechea
Mark Hamill hace el papel de Mr. Swan.
Glenn Close interpreta a Self en la serie.
Pierce Brosnan interpreta a Self en la serie.
Danny DeVito hace el papel de Self.
Martin Short interpreta a Self en la serie.
Dominic Monaghan hace el papel de Self.
Kim Cattrall hace el papel de Self.
William H. Macy hace el papel de Self.
Will Smith hace el papel de Self.
Jeffrey Tambor hace el papel de Self.
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