- Hermione Norris - Vivien Lake
- Michael Smiley - Benny Silver
- Paul McGann - Mark North
- Ruth Wilson - Alice Morgan
- Warren Brown - DS Justin Ripley
- Laura Haddock - Megan Cantor
- Patrick Malahide - George Cornelius
- John Heffernan - Steven Rose
- Wunmi Mosaku - Detective Sgt. Catherine Halliday
- Enzo Cilenti - Jeremy Lake
- Kierston Wareing - Caroline Jones
- Rose Leslie - DS Emma Lane
- Dermot Crowley - DSU Martin Schenk
- Dermot Crowley - DCI Martin Schenk
- Paul Rhys - Lucien Burgess
- Sean Pertwee - Terry Lynch
- Nicola Walker - Linda Shand
- Alexander Morton - Bill Winingham
- Andrew Tiernan - Richard Henley
- Louise Rose - Corrine Day
- Rob Jarvis - Graham Shand
- Ross McCall - Daniel Sugarman
- Ania Sowinski - Evangeline Nixon
- Matti Houghton - Layla
- Luke Ward-Wilkinson - Owen Woodward
- Thomas Lockyer - James Carrodus
- Jami Reid-Quarrell - James Hauser
- Michael Obiora - Errol Minty
- Roberta Taylor - Celia Lavender
- Anthony Howell - Palmer
- Nicholas Asbury - DCI Woodgate
- Glen Stanway - Police Constable (uncredited)
- Sam Spruell - Owen Lynch
- Diveen Henry - PC Jenny Hanson
- Gary Shelford - PC Mardel
- Catherine Balavage - Hoodie (uncredited)
- Catherine Hamilton - Kirsten Ross
- Chris Wilson - Police Firearms Officer (uncredited)
- Chris Wilson - Police Officer (uncredited)
- Mark Redguard - Policeman
- Anton Saunders - Henry Madsen
- Johann Myers - Dennis Keaton
- Stacey Sampson - Claire Weldon
- Okorie Chukwu - PC Alistair Fulford
- Katie Hardwick - Monika Poole (uncredited)
- Donatienne Dupont - Jessica Carrodus
- Danny Lee Wynter - Tom Meyer
- Graham Turner - Patrick Holguin
- Matthew Marsh - DCSU Russell Cornish
- Anna Brewster - Abby
- Bryony Afferson - Candice Calvert
- Lee Ingleby - Cameron Pell
- Brett Fancy - Paul Hoby
- John Albasiny - Andrei Kolchak
- Jamie Martin - Boothe
- Keeley Forsyth - Wilson
- Nigel Cooke - Ronald Bryson
- Golda Rosheuvel - Sally Thomas
- Babou Ceesay - Adewale Omotoso
- James Puddephatt - Steve Kimble
- Hamza Jeetooa - Depak Chandrapal
- Steven Robertson - Robert Millberry / Nicholas Millberry
- Pam Ferris - Baba
- Alan Williams - Frank Hodge
- David Dawson - Toby Kent
- Ellie Haddington - DCS Linda Carroway
- Stephen Boxer - Joe Shepherd
- Shaun Mason - Sean 'Beanie' Beamish
- Kevin Fuller - Paul Ellis
- Sasha Behar - Dani Lane
- Selva Rasalingam - Craig Lane
- Laura Pyper - Jodie
- Orlessa Altass - Ayesha
- Ned Dennehy - William Carney
- Lucian Msamati - Ken Barnaby
- Maria Miles - Tessa Barnaby
- Lizzie Hopley - Dr. Joy Harris
- Alexandra Moen - Eve
- Mark Rowley - Callum
- Gemma Lawrence - Maxine
- Oliver Stark - Shaun Butler
- Ryan Calais Cameron - Steve Meredith
- Rupert Procter - Terrence Conran
- Michael Shaeffer - Gordon Murray
- Jason Riddington - Alan Ramsey
- Michelle Duncan - Kiera Mills
- Elliot Cowan - Tom Marwood
- Georgina French - Natalie Green
- Simon Wilson - Dr. Joe Green
- Joanna Croll - Chloe Morley
- Darren Boyd - DCI Theo Bloom
- Simone James - Mel Cornelius
- Charlotte Pyke - Roberta Wise
- Lorraine Hilton - June Segar
- Tommy French - Declan Segar
- Ash Rizi - Mohan Rai
- Annabel Bates - Tara Black
- Selin Hizli - Stacey Bell
- Hannah Bourne - Katie Woodward
- Emma Fischer - Hannah Woodward
- Lewis Young - William Lucas
- Vincent Vermignon - Monsieur Awaritefe
- Eleanor Hafner - Eleanor Cadman
- Lex Daniel - Ronald Massey
- Delroy Atkinson - Derek Hayes
- Andrew Mullan - Alastair Cornelius
- Katie Brayben - Penny Leyton
- Robert Bannon - Andy King
- Sonita Henry - Daria Shubik
- Andreea Paduraru - Ileana
- Hiten Patel - PC Singh
- Glenn Webster - SCO19 Armed Police Officer
- Paul Englishby
David O'Hara interpreta a DSU George Stark en la serie.
Steven Mackintosh hace el papel de DCI Ian Reed.
Idris Elba hace el papel de DCI John Luther.
Dermot Crowley interpreta a DSU Martin Schenk en la serie.
Hermione Norris interpreta a Vivien Lake en la serie.
Michael Smiley interpreta a Benny Silver en la serie.
Ruth Wilson interpreta a Alice Morgan en la serie.
Patrick Malahide hace el papel de George Cornelius.
Wunmi Mosaku hace el papel de Detective Sgt. Catherine Halliday.
Enzo Cilenti hace el papel de Jeremy Lake.
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