- Vicki Pepperdine - Doctor
- Kim Allan - Catriona
- Daisy Beaumont - Vicar
- Sharon Young - Jemima
- Nikki Amuka-Bird - Anna Leslie
- Cara Theobold - Ilona
- Oliver Coopersmith - Scott
- Tom Stourton - Ivan
- Isabelle Joss - Receptionist
- Mike Wozniak - Doctor
- Molly Innes - Female Patient
- Rosalie Craig - Bethany
- Clare Wille - Diana
- Tala Gouveia - Naomi
- Duncan Pow - Gareth
- Sharon MacKenzie - Phoebe's Mother
- Sara Vickers - Cara
- Elena Saurel - Bianca
- Solomon Israel - Greg
- Susannah Fielding - Phoebe Morris
- Susannah Fielding - Phoebe
- John-Luke Roberts - Nathan
- Lolly Adefope - Charlotte
- Kieran Hodgson - Simeon
- Tom Cox - Andy
- Oliver Powell - Ed
- Jaz Deol - Adal
- Claudia Jessie - Tasha
- Eleanor Wyld - Gabby
- Alex Lowe - Steve
- Paul Ritter - Peter
- Melanie Hudson - Martha
- Siobhan Redmond - Janie
- Tony Gardner - Julian
- Klariza Clayton - Holly
- Pearce Quigley - Simon
- Jade Ewen - Miranda
- Paul Longley - Rob
- Greg Miller Burns - Christian
- Tom Golding - Jamie
- Laura Evelyn - Receptionist
- Florence Hall - Georgina
- Ian Kelsey - James Hamilton
- Sophie Stevens - Nicole
- Jessica Ellerby - Jane Angell
- Chris Donald - Laurence
- Yasmine Akram - Jonesy
- Deborah Findlay - Fiona
- Karl Johnson - Richard
- Cassie Layton - Emma
- Turlough Convery - McNeish
- Jamie Demetriou - Samuels
- David Westhead - Alexander
- Stephen Wight - Jonno
- Jenny Bede - Isabel
- Gabby Best - Wendy
- Riann Steele - Cleo
- Robert Lonsdale - Steve
- Jade Ogugua - Amy
- Rob Crouch - Vince
- Tom Bell - Ben
- Richard Thomson - Mal
- Bekka Bowling - Zoe
- Hannah Britland - Abigail Saunders
- Laura Aikman - Jo
- Antonia Clarke - Frankie
- Oliver Alvin-Wilson - Alex
- Jordan Coulson - Robbie
- Dolina MacFarlane
- Gordon Anderson
- Elliot Hegarty
- Becca Toogood
- Angela Murray
- Tom Edge
- Rosalie Clayton
- Charlie Leech
- Murray Ferguson
- Simon Gershon
- Si Begg
Johnny Flynn interpreta a Dylan Witter en la serie.
Antonia Thomas hace el papel de Evie Douglas.
Daniel Ings interpreta a Luke Curran en la serie.
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