- Ashlie Atkinson - Teacher
- Nimo Gandhi - Taxi Driver #1
- Chelsea Peretti - Date
- Stephanie Berry - Principal
- Parker Posey - Liz
- David Lynch - Jack Dall
- Chris Rock - Chris
- Rick Crom - Rick
- Robin Williams - Robin
- Yvonne Strahovski - Blake
- Sarah Baker - Vanessa
- Devin Druid - Young Louie
- Liam Broggy - Little Boy
- Lynn Marocola - Knicks Fan (uncredited)
- Jeremy Renner - Jeff Davis
- Skipp Sudduth - Mr. Hoffman
- Cory Nichols - Brad
- Oscar Wahlberg - Danny
- Mireille Crocco - Concert Goer #2
- Sofia Hublitz - Danielle Hoffman
- Gina Piersanti - Laurie
- Sebastian Quinn - Concert Goer #1
- Tony V. - Principal Doug Miner
- Lily Peterson - Student
- Liz Holtan - Ellen
- Jay Russell - Jay
- Kim Barlow - Tammy
- Nicole Ehinger - Young Tammy
- Eddie Brill - Eddie
- Ian Jarvis - Mediator
- Jim Norton - Jim
- William Stephenson - Bus Driver
- Kathleen Butler - Naked Woman
- Jay Oakerson - Bathroom Guy
- Nilaja Sun - Woman on Phone
- Elisabeth Hower - Trisha
- Meghan Rafferty - Parent #2
- Tatsuya Rivera - Serge
- Laurine Towler - Parent #1
- James Schram - The Bartender (uncredited)
- Cliff Samara - Patient
- Robert Kelly - Bobby
- Robert Kelly - Robbie
- Manny Siverio - Comedy Cellar Patron (uncredited)
- Gregory Gunter - Dennis
- Kate Blumberg - Martha
- Dan Ziskie - Sheriff
- Hannibal Buress - Hannibal
- Hannibal Buress - Hannibal (uncredited)
- Ben Jeffrey - Curtis
- Elizabeth Morton - Doreen
- Samia Akudo - Flight Attendant
- Stephen Badalamenti - TSA Agent
- Todd Glass - Guy on Phone
- Michael H. Ingram - Angry Man
- David Patrick Kelly - Therapist (uncredited)
- David Patrick Kelly - Therapist
- Austin Jones - Heckler #1
- Johnnie Mae - TSA Supervisor
- Nancy Robinette - Woman Passenger
- Rich Rothbell - Pushy Airport Suit (uncredited)
- Matthew Broderick - Matthew Broderick
- Hayley Podschun - Laurie
- Gerry Vichi - Simon
- Megan Hilty - Heckler
- Adam Escott - A.D.
- Sylvia Kauders - Woman
- Clinton Lowe - Thug #2
- Kenneth Maharaj - Cashier
- Reza Salazar - Thug #1
- Barbara Spiegel - Joan
- Nancy Shayne - Nancy
- Nancy Shayne - Teacher
- Amy Landecker - Sandra
- Amy Landecker - Louie's Mother
- Amy Landecker - Louie's Mom
- Justin Gray - Sound Mixer (uncredited)
- Myq Kaplan - Myq Kaplan (uncredited)
- Kurt Metzger - Kurt Metzger (uncredited)
- Mary Louise Wilson - Dorethy
- Ana Cruz Kayne - Jasmine
- Josh Hamilton - Jeff
- Tracee Chimo - Dog Pound Volunteer
- Will Brill - Guy #1
- Carla Corvo - College Girl #1
- Todd Davis - City Worker
- Christine Donlon - Jeff's Wife
- Audrey Lynn Weston - Girl Behind Counter
- Cary Woodworth - Guy #2
- Sonya Cooke - Office Assistant (uncredited)
- Michael Drayer - Sean
- Danny Burstein - Mike
- Moisés Acevedo - Jock #4
- Abraham Alvarez - Louie's Father
- Elena McGhee - Grace
- Jack Tartaglia - Jimmy
- Gina Hernandez - High End Executive (uncredited)
- Stephen Root - Dr. Hepa
- Chuck Sklar - Osama Bin Laden
- Adepero Oduye - Tarese
- Mando Alvarado - Manager
- Bonita Elery - Tarese's Sister
- Ann Dowd - Sister Carson
- Tom Noonan - Dr. Haveford
- Ricky Gervais - Dr. Ben
- Bobby Cannavale - Chris
- Stephen C. Bradbury - Dr. Drake
- Kate Gilligan - Anchorwoman
- Ted Alexandro - Flyer Comic
- Ann Carr - Karen
- Kelly Deadmon - Lisa
- Nick Di Paolo - Nick
- Ardie Fuqua - Ardie
- Godfrey - Godfrey
- Rusty Schwimmer - Gretchen
- Yul Vazquez - Pedro
- Roderick Hill - Peter
- Maria Dizzia - Delores
- Munro M. Bonnell - Crazy Homeless Man
- Liza Colón-Zayas - Miss Hernandez
- Ryan Fitzsimmons - Man with Janice
- Kayli Gural - Girl in School Hallway (uncredited)
- Peter Hans Benson - Ken
- Donna Hanover - Gloria
- Todd Barry - Todd
- Sam Haft - Young East Village Dude
- Michael Torpey - Male Realtor
- Teena Byrd - Bar Patron (uncredited)
- Martin Pfefferkorn - Homeless Replacement (uncredited)
- Conner O'Malley - Young Louie
- M. Blair Breard - Producer (uncredited)
- Louis C.K.
- Dave Becky
Chris Rock hace el papel de Chris.
Robin Williams hace el papel de Robin.
Louis C.K. interpreta a Louie en la serie.
Matthew Broderick interpreta a Matthew Broderick en la serie.
David Patrick Kelly interpreta a Therapist en la serie.
Pamela Adlon interpreta a Pamela en la serie.
Hadley Delany hace el papel de Lilly.
Ursula Parker interpreta a Jane en la serie.
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