- Jennifer Hale - Ms. Marvel (voice)
- Peter Jessop - Vision (voice)
- James C. Mathis III - Black Panther (voice)
- Mark Hamill - Klaw (voice)
- Vanessa Marshall - Black Widow (voice)
- Roger Craig Smith - Captain Marvel (voice)
- Kari Wuhrer - Maria Hill (voice)
- Troy Baker - Clay Quartermain (voice)
- Troy Baker - David Cannon / Whirlwind / Paul Pierre Duval / Grey Gargoyle / Clay Quartermain (voice)
- Troy Baker - Clay Quartermain / Donnie Gill / Blizzard / David Cannon / Whirlwind (voice)
- Graham McTavish - Loki (voice)
- Gary Anthony Williams - Eliot Franklin / Thunderball / Paramedic (voice)
- Nika Futterman - Sif (voice)
- Keith Ferguson - Gen. 'Thunderbolt' Ross / Cop (voice)
- Nolan North - Brian Calusky / Piledriver / Balder / Dispatch (voice)
- Nolan North - Scientist Supreme / Jimmy Woo / Arthur Parks / Living Laser / Balder (voice)
- Jonathan Adams - Nathaniel Richards / Kang the Conqueror (voice)
- Scott Menville - James Barnes / Bucky (voice)
- Cindy Robinson - Ravonna Lexus Renslayer (voice)
- Phil LaMarr - J.A.R.V.I.S. (voice)
- Phil LaMarr - J.A.R.V.I.S. / HYDRA Soldier (voice)
- Phil LaMarr - J.A.R.V.I.S. / Hulkbuster Soldier (voice)
- Hakeem Kae-Kazim - T'Chaka (voice)
- Jim Ward - Baron Wolfgang von Strucker (voice)
- Jim Ward - Damocles / 1940s Announcer / Baron Wolfgang von Strucker (voice)
- Cam Clarke - Doc Samson / Simon Utrecht / Vector (voice)
- Cam Clarke - Doc Samson / Hulkbuster Pilot (voice)
- Cam Clarke - Doc Samson / Frank Payne / Constrictor (voice)
- Danny Mann - Mad Thinker (voice)
- JB Blanc - Dirk Garthwaite / Wrecker / Heimdall / Ymir - Frost Giant #1 (voice)
- JB Blanc - Heimdall (voice)
- Robin Atkin Downes - Emil Blonsky / Abomination (voice)
- Robin Atkin Downes - Heinrich Zemo / Baron Zemo (voice)
- Kari Wahlgren - Amora / Enchantress (voice)
- Kari Wahlgren - Amora / Enchantress / Jane Foster / Beautiful Woman (voice)
- Kari Wahlgren - Jane Foster (voice)
- Steve Blum - Johann Schmidt / Red Skull / HYDRA Scientist / James Howlett / Ogre (voice)
- Steve Blum - Beta Ray Bill (voice)
- Lance Henriksen - Eric Williams / Grim Reaper (voice)
- Kevin Michael Richardson - M'Baku / Man-Ape / N'Gassi (voice)
- Jeffrey Combs - Samuel Sterns / The Leader (voice)
- Erin Torpey - Susan Storm / Invisible Woman (voice)
- David Kaufman - Johnny Storm / The Human Torch (voice)
- Lex Lang - Victor Von Doom / Dr. Doom (voice)
- Kirsten Potter - Lucia von Bardas (voice)
- Quinton Flynn - Malekith the Accursed (voice)
- Clancy Brown - Odin (voice)
- Dee Bradley Baker - Reed Richards / Mr. Fantastic (voice)
- Dee Bradley Baker - Reed Richards / Mister Fantastic (voice)
- Mick Wingert - Skuttlebutt (voice)
- John DiMaggio - Eitri (voice)
- Kirk Thornton - Adam Warlock / Cop (voice)
- Moira Quirk - Phyla-Vell / Quasar (voice)
- Crispin Freeman - Scott Lang / Ant-Man / Thug 2 (voice)
- Drake Bell - Peter Parker / Spider-Man (voice)
- J.K. Simmons - J. Jonah Jameson (voice)
- Jack Kirby
- Alan Fine
- Dana Tafoya Cameron
- Eric S. Rollman
- Joe Quesada
- Dan Buckley
- Leanne Moreau
Mark Hamill interpreta a Klaw (voice) en la serie.
Hakeem Kae-Kazim interpreta a T'Chaka (voice) en la serie.
Lance Henriksen hace el papel de Eric Williams / Grim Reaper (voice).
Drake Bell hace el papel de Peter Parker / Spider-Man (voice).
Eric Loomis interpreta a Iron Man (voice) en la serie.
Brian Bloom hace el papel de Captain America (voice).
Rick D. Wasserman interpreta a Thor (voice) en la serie.
Colleen O'Shaughnessey interpreta a Wasp (voice) en la serie.
Chris Cox interpreta a Hawkeye (voice) en la serie.
Fred Tatasciore interpreta a Hulk (voice) en la serie.
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