- Keke Palmer - Maya (voice)
- A Boogie Wit Da Hoodie - KG (voice)
- Lizzo - Lizzo (voice)
- Tiffany Haddish - Ms. Hill (voice)
- Cee Lo Green - Shuggie (voice)
- Bretman Rock - Makeup Boy (voice)
- Aldis Hodge - Frankie (voice)
- Tone Loc - Penny's Singing Voice (voice)
- Bridgette Bryant - Trudy as Minnie Ripperton (voice)
- Rob Riggle - Rob Riggle (voice)
- Marsai Martin - Iyanna (voice)
- Arturo Castro - Neato Tito (voice)
- Aries Spears - Sir Paid-a-Lot (voice)
- Lamorne Morris - Lamorne Morris (voice)
- Logan Browning - College Penny (voice)
- Lena Waithe - College Maya (voice)
- Karrie Martin Lachney - College LaCienega (voice)
- Carlos Alazraqui - Puff (voice)
- Carlos Alazraqui - Puff (voice) / Mr. Chips (voice)
- Jeremy O. Harris - College Michael (voice)
- Cree Summer - Peabo (voice)
- Cree Summer - Bufferina (voice)
- Desus Nice - College KG (voice)
- Alvaro Guttierez - Papi (voice)
- Carlos Mencia - Felix (voice)
- Kevin Michael Richardson - Doctor Payne (voice) / Papi Laugh (voice)
- Kevin Michael Richardson - Papi Laugh (voice) / Mr. Chevalier (voice) / Helmet Guy (voice)
- Kevin Michael Richardson - Man (voice)
- Marcus T. Paulk - 10-Year-Old Charles (voice)
- Marcus T. Paulk - Myron (voice)
- Lil Nas X - June Bug (voice)
- Maria Canals-Barrera - Sunset (voice)
- Patricia Belcher - Principal Hightower (voice)
- Zachary Quinto - Barry (voice)
- Billy Porter - Randall (voice)
- Princess Nokia - LaBrea (voice)
- Tina Knowles - Ms. Gina (voice)
- Kid Capri - Kid Capri (voice)
- Eva Longoria - Melrose (voice)
- Asante Blackk - Kareem (voice)
- Art Evans - Charlie (voice)
- Debbie Allen - Myrtle (voice)
- D.C. Young Fly - Man-Man (voice)
- Dominique Fishback - 12-Year-Old Suga Mama (voice)
- Glynn Turman - Pa (voice)
- James Pickens Jr. - Charles (voice)
- Lawrence Hilton-Jacobs - Chuck (voice)
- Bresha Webb - CeCe (voice)
- Brenda Song - Vanessa Vue (voice)
- Kimberly Brooks - Harriet (voice)
- Ralph Farquhar
- Jan Hirota
- Bruce W. Smith
- Calvin Brown Jr.
- Chloe Bailey
- Joyce Wrice
- Halle Bailey
- Kurt Farquhar
Kyla Pratt interpreta a Penny Proud (voice) en la serie.
Tommy Davidson interpreta a Oscar Proud (voice) en la serie.
Paula Jai Parker hace el papel de Trudy Parker-Proud (voice).
Jo Marie Payton interpreta a Suga Mama Proud (voice) en la serie.
Karen Malina White interpreta a Dijonay Jones (voice) en la serie.
Soleil Moon Frye interpreta a Zoey Howzer (voice) en la serie.
Alisa Reyes interpreta a LaCienega Boulevardez (voice) en la serie.
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