- Mariah Carey - Mariah Carey (voice)
- Alicia Keys - Alicia Keys
- Pablo Santos - Delivery Boy / Johnny Lovely (voice)
- Maria Canals-Barrera - Sunset Boulevardez (voice)
- Alvaro Guttierez - Papi Boulevardez (voice)
- Raquel Lee - Nubia Gross (voice)
- Raquel Lee - Nibia Gross (voice)
- Carlos Mencia - Felix Boulevardez (voice)
- Karen Maruyama - Additional Voices (voice)
- Karen Maruyama - Marsha Mitsubishi (voice)
- Karen Maruyama - Marsha Mitsubishi / Teens (voice)
- Brenden Jefferson - Teenage Voices (voice)
- Marcus T. Paulk - Myron Lewinski (voice)
- Chick Hearn - Self (voice)
- Bruce Vilanch - Tristan the Magician (voice)
- Cedric the Entertainer - Bobby Proud (voice)
- Aries Spears - Wizard Kelly (voice)
- Aries Spears - Wizard Kelly / Sir-Paid-A-Lot (voice)
- Aries Spears - Wizard Kelly / Sir Paid-A-Lot (voice)
- Aries Spears - Wizard Kelly / Sir-Paid-A-Lot / Li'l Wiz Jr. (voice)
- Gedde Watanabe - Mr. Min (voice)
- Ray J - Mega (voice)
- James Avery - Crandall Smythe (voice)
- Ron Glass - The Talking Baby (voice)
- Ken Lawson - Timothy Smythe (voice)
- Lydia Look - The Chang Triplets (voice)
- Gloria Allred - Gloria Cochran (voice)
- Jeff Bennett - White Joseph (voice)
- Jeff Bennett - Additional Characters (voice)
- Jeff Bennett - Director (voice)
- Jeff Bennett - Announcer (voice)
- Mablean Ephriam - Self (voice)
- Michele Lisette Jennings - Additional Voices (voice)
- Michele Lisette Jennings - Ginger S. Kelly (voice)
- Sandra Oh - Marsha Mitsubishi (voice)
- Aldis Hodge - Frankie (voice)
- Elizabeth Daily - Singer (voice)
- Kel Mitchell - Carlos (voice)
- Bebe Drake - Mary Darnell (voice)
- Myra J. - Mamie Darnell (voice)
- Dorien Wilson - Dave Daniels (voice)
- Hattie Winston - Gertie Dinkins (voice)
- Steve Harvey - The Credit Card (voice)
- Vivica A. Fox - Margaret (voice)
- Samuel L. Jackson - Joseph (voice)
- Pat Crawford Brown - Agnus (voice)
- Raven-Symoné - Stephanie (voice)
- Earl Billings - Photographer (voice)
- Shania Accius - Customer (voice)
- Shania Accius - Taylor (voice)
- Lou Rawls - Self (voice)
- Al Roker - Roker / Little Rokers (voice)
- Carmen Carter - Singer (voice)
- Alvin Chea - Singer (voice)
- Bobbi Page - Singer (voice)
- Patricia Belcher - Juicy's Owner (voice)
- Thomas Mikal Ford - Mr. Webb (voice)
- Stephen Root - Mr. Andrews (voice)
- Lauren Maltby - Samantha (voice)
- Phil LaMarr - Michael (voice)
- Phil LaMarr - Mr. Chang / Mr. Eddie (voice)
- Phil LaMarr - Coach Collins / Michael (voice)
- Phil LaMarr - Michael / Director / Denzel Washington (voice)
- Phil LaMarr - Chef O'boy / Automated Voice / Policeman (voice)
- Phil LaMarr - Ride Operator / Thor (voice)
- Phil LaMarr - Cashier (voice)
- Phil LaMarr - Michael / Pookie (voice)
- Phil LaMarr - Pierre / Michael (voice)
- Phil LaMarr - Gangster (voice)
- Phil LaMarr - Michael / Anchorman (voice)
- Phil LaMarr - Jim Lampley Kid (voice)
- Phil LaMarr - Thingy (voice)
- Phil LaMarr - Additional Voices (voice)
- Phil LaMarr - Jack Stone / Mr. Chang / Referee (voice)
- Phil LaMarr - Coach Collins / Chick Robinson (voice)
- Phil LaMarr - Fireman / Coach Collins / Michael (voice)
- Phil LaMarr - Michael / Ticket Seller / Presto the Great (voice)
- Shia LaBeouf - Johnny McBride (voice)
- Cree Summer - Babies (voice)
- Cree Summer - Peabo (voice)
- Cree Summer - Mother (voice)
- Cree Summer - Iesha's Little Brother (voice)
- Kevin Michael Richardson - Klaus (voice)
- Kevin Michael Richardson - Additional Characters (voice)
- Kevin Michael Richardson - Omar / Cannibal (voice)
- Kevin Michael Richardson - Papi Laugh / Man (voice)
- Kevin Michael Richardson - Additional Voices (voice)
- Kevin Michael Richardson - Omar / Announcer #2 (voice)
- Kevin Michael Richardson - Jethro (voice)
- Kevin Michael Richardson - Papi Laugh / Omar (voice)
- Kevin Michael Richardson - Mr. Carson / Papi Laugh (voice)
- Kevin Michael Richardson - Omar (voice)
- Kevin Michael Richardson - Papi Laugh (voice)
- Kevin Michael Richardson - Announcer / Klaus / Tour Narrator (voice)
- Kevin Michael Richardson - Principal / Dr. Payne / Mr. Gross (voice)
- Kevin Michael Richardson - Papi Laugh / Brunswick (voice)
- Kevin Michael Richardson - Dr. Payne / Papi Laugh / Klaus (voice)
- Kevin Michael Richardson - Omar / Mr. Webb / Papi Laugh (voice)
- Kevin Michael Richardson - Narrator (voice)
- Kevin Michael Richardson - Brocko (voice)
- Kevin Michael Richardson - Sergeant Smelly / Teacher / Punk / Klaus (voice)
- Jacob Vargas - Punch Alto (voice)
- Khary Payton - Slapmaster (voice)
- Freddy Rodríguez - Stomp (voice)
- Lamont Bentley - Gary (voice)
- Big Boy - Self (voice)
- Shar Jackson - Bethany (voice)
- Shaun Robinson - Self (voice)
- Dante Basco - Quoc Wong (voice)
- Amy Hill - Mrs. Wong (voice)
- Benjamin Lum - Mr. Wong (voice)
- Sheryl Lee Ralph - Diana Parker (voice)
- Jeffrey Tambor - Randolph Verascola (voice)
- Tim Conway - Alvin Peterson (voice)
- Ving Rhames - Garrett Krebs (voice)
- Romeo Miller - Lil' Romeo (voice)
- Michael Winslow - Additional Voices (voice)
- Vanessa Williams - Debra (voice)
- Yasiin Bey - Mos Def (voice)
- Mo'Nique - Boonnetta (voice)
- Cicely Tyson - Mrs. Maureen Parker (voice)
- Robert Guillaume - Dr. Parker (voice)
- David Alan Grier - Reuben (voice)
- Anthony Anderson - Ray Ray (voice)
- Solange - Chanel (voice)
- Jamal Mixon - Ray Ray Junior (voice)
- Gabrielle Union - Sunny Stevens / Iesha (voice)
- Wendy Raquel Robinson - Katanga (voice)
- Wendy Raquel Robinson - Leslie (voice)
- Carlos Alazraqui - Puff (voice)
- Carlos Alazraqui - Additional Voices (voice)
- Carlos Alazraqui - Monkeys / Puff (voice)
- Greg Watanabe - Additional Voices (voice)
- Kym Whitley - Mamma (voice)
- Brandon Baker - Duke Anoi (voice)
- Keone Young - Parker Lee (voice)
- William Allen Young - Mr. Moody (voice)
- Bruce W. Smith
- Solange
- Beyoncé
- Kelly Rowland
- Michelle Williams
- Gerald 'Gee Gee' Harbour
- Kurt Farquhar
Jeffrey Tambor interpreta a Randolph Verascola (voice) en la serie.
Yasiin Bey interpreta a Mos Def (voice) en la serie.
Samuel L. Jackson interpreta a Joseph (voice) en la serie.
Vivica A. Fox interpreta a Margaret (voice) en la serie.
Kyla Pratt hace el papel de Penny Proud (voice).
Tommy Davidson interpreta a Oscar Proud (voice) en la serie.
Tara Strong interpreta a BeBe Proud / CeCe Proud / Puff (voice) en la serie.
Paula Jai Parker hace el papel de Trudy Parker-Proud (voice).
Jo Marie Payton interpreta a Suga Mama Proud (voice) en la serie.
Alisa Reyes interpreta a LaCienega Boulevardez (voice) en la serie.
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