- JoAnna Cameron - Jan Speiser
- Kay Peters - Dr. Blythe Collier
- Berkeley Harris - Dr. Hal Coulter
- Della Reese - Grace Dayton
- Eric Laneuville - Bruce Dayton
- Edward Faulkner - Dr. Hill
- Paul Gleason - Smith
- Len Lesser - Joe Boland
- Ray Ballard - Maxie
- Jane Wyman - Dr. Amanda Fallon
- Mike Farrell - Dr. Vic Wheelwright
- Virginia Gregg - Dorothy
- Virginia Gregg - Nurse Anne Turner
- Ron Howard - Cory Merlino
- Robert Hogan - Jack Merlino
- Philip Brown - Scotty Merlino
- Lynnette Mettey - Dee Merlino
- Leslie Nielsen - Mr. Cummings
- Kathleen Nolan - Carol Steadman
- Miko Mayama - Irene Watanabe
- Eve Brent - 1st Nurse
- Eve Brent - 2nd Nurse
- Jason Bernard - Dr. Griffith
- Michael Lerner - Parelli
- Roy Engel - 1st Doctor
- Linda Dangcil - Celia Hernandez
- Linda Dangcil - Elena Rodrigues
- Stuart Randall - 2nd Doctor
- Harry Harvey - Elderly Heart Patient (uncredited)
- Harold J. Stone - Harry Miller
- Pernell Roberts - Dr. Frank Bartell
- Carmen Zapata - Rosa Villacres
- James B. Sikking - 1st Reporter
- Joanne Linville - Anne Sorenson
- Arch Johnson - Frank Sorenson
- Lincoln Kilpatrick - Gil Dodds
- Anne Whitfield - Milly
- Pat Crowley - Helen Johnson
- Louis Gossett Jr. - Dr. Karnes
- McLean Stevenson - George Caldwell
- Frank Converse - Curt Boyle
- Shirley Knight - Marci Boyle
- Dabney Coleman - Dr. Goldstone
- Michael Anderson Jr. - Jerry
- George Murdock - Albert Prescott
- Ann Prentiss - Elaine Stone
- John Lupton - Kenneth Parker
- Darby Hinton - Hal Parker
- Julie Bennett - Eve Parker
- Loretta Swit - Rosalyn
- Jeff Donnell - Nurse Klein
- Don Stroud - Milt Butcher
- Gene Raymond - Walter Markle
- Paul Bryar - Judge Morley
- Joan Swift - Mary
- Dick Cherney - Juror (uncredited)
- Dick Simmons - Slidell (uncredited)
- Richard Anderson - Dr. Lensky
- Marlyn Mason - Hanna Feinstein
- Herb Edelman - Howard Feinstein
- Peter Brocco - Father Smith
- Dawn Lyn - Melissa Feinstein
- Florence Lake - Lizzy
- Herbert Hirschman
- Robert Scheerer
Michael Lerner interpreta a Parelli en la serie.
John Saxon interpreta a Dr. Theodore Stuart en la serie.
Julie Adams interpreta a Lynn Craig en la serie.
E.G. Marshall hace el papel de Dr. David Craig.
David Hartman interpreta a Dr. Paul Hunter en la serie.
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