- Mouna Traoré - Rebecca James
- Thomas Craig - Inspector Thomas Charles Brackenreid
- Daniel Maslany - Detective Llewellyn Watts
- Ingrid Kavelaars - Beth Tipton
- Kristin Fairlie - Petunia
- Maria del Mar - Sarah Pensell
- Chad Connell - Prince Alfred
- Peter Keleghan - Terrence Meyers
- Robbie Amell - Wallace Driscoll
- Nicholas Campbell - Buffalo Bill Cody
- Tyler Kyte - Clyde Dunbar
- Stephen McHattie - Harry Murdoch
- Rick Roberts - Dr. Gilbert Birkins
- Richard Waugh - Peter Watt
- Natalie Radford - Daisy Hanson
- Amy Rutherford - Ellen Granger
- Sarah Gadon - Ruby Ogden
- Tom McCamus - Judge Mitchell Wilson
- Mary Walsh - Sally Smoot
- Michael Seater - James Gillies
- Martha Burns - Mrs. Burgess
- Kristopher Turner - Sam Fineman
- Chris Gascoyne - David Jennings
- Sarah Strange - Annie Oakley
- Geordie Johnson - Barclay Blake
- Dmitry Chepovetsky - Nikola Tesla
- James Gallanders - Father Franks
- Dylan Neal - Sergeant Jasper Linney
- Daniel Fathers - Calvin Baker
- Joe Dinicol - Harry Houdini
- Jonathan Potts - Levi Beecher
- Marc Bendavid - Robert Perry
- Laurie Murdoch - Martin Hammerton
- Albert Schultz - Isaac Begelman
- Nathaniel Arcand - Jimmy McLeod
- Tamara Hope - Edna Garrison
- Matt Gordon - Rudolph Sutton
- Gema Zamprogna - Cecile Braxton
- Shane Daly - Vincent Newcombe
- Krista Bridges - Madame Ettie Weston
- Waneta Storms - Eunice McGinty
- Kerry McPherson - Mary Ann McConnell
- Joel S. Keller - Thomas Merrick
- Doug McGrath - Old Dan
- Patrick Creery - Crown Prosecutor
- Peter Mooney - Tobias Allan
- William Shatner - Mark Twain
- Andrew Gower - Sherlock Holmes / David Kingsley
- Jonathan Llyr - Mick O'Shea
- Sara Mitich - Lillian Moss
- Rebecca Liddiard - Lisette Barnes
- Leeah Wong - Ling Lawrence
- Alison Louder - Lucy Maud Montgomery
- Peter Michael Dillon - Wayland Porter
- Patrick McManus - Detective Harvey Walker
- Steven Yaffee - Arthur Elliot
- Benjamin Sutherland - Jack Gourlay
- Tracey Ferencz - Mrs Dawkins
- Jo Chim - Ling
- Jeff McEnery - Barry Biggs
- Catherine McNally - Head Nurse
- A.C. Peterson - Edwin Dodd
- David Huband - Daniel Pratt
- Tamsen McDonough - Alice Howard
- Sarah Orenstein - Clara Pollack
- Dylan Taylor - Agent Felder
- Dylan Taylor - Phillip Delany
- Mishka Thébaud - Alexander Cuddy
- Dominique Provost-Chalkley - Elizabeth Atherly
- Max Morrow - Clarence
- Amber Goldfarb - Hannah Rice
- Charles Vandervaart - John Brackenreid
- Stephane Garneau-Monten - Brackenreid Boudoir
- Craig Brown - Eddie Crawford
- Brett Houghton - Walter Moore
- Caroline Palmer - Faye Sloan
- Emily Nixon - Mrs. Sommer
- Tomaso Sanelli - Yitzhak
- Dakota Goyo - Alwyn Jones
- Nikki Duval - Effie Nolan
- Jessica Phillips - Felicity Wallace
- Richard Davis - Finn Hopkins
- Sophie McShera - Ann Ryand
- James Kall - Michael Dubois
- Thomas Mitchell Barnet - Stuart McGovern
- Kate Hewlett - Lucy Worthing
- Brittaney Bennett - Enid McInnes
- Angela Besharah - Dorothy McCallister
- Patrick Garrow - Helmut Lindermann
- Patrick Garrow - Allen Fawkes
- Rachel VanDuzer - anabella maloney
- Sophie Goulet - Marilyn Clark
- Jimi Shlag - Wilbur Benedict
- Scott Farley - Eli Goss
- Robin Archer - Patient
- Carlyn Burchell - Sarah Davis
- Nabeel El Khafif - Ferguson
- Tadhg McMahon - Barkeep
- Tadhg McMahon - Foreman
- Sava Drayton - Norman
- Brad Austin - Clifford Sifton
- Caleigh Le Grand - Townsperson
- Alexander Elliot - Buster Keaton
- Matthew Finlan - Charlie Chaplin
- Ali Hassan - Obie Stratford
- Peter Stebbings - James Pendrick
- Matthew Bennett - Allen Clegg
- Christine Horne - Svetlana Tsiolkofsky
- Jeff Teravainen - Inspector Arthur Dreadnaught
- Alex Hatz - Percival Emerson
- Nathalie Toriel - Anne Marie Thiery
- Geoffrey Owens - President Theodore Roosevelt
- Marty Moreau - President Theodore Roosevelt
- Marty Moreau - Constable Morrison
- Dan Lett - Fredrick Waters
- Tom Barnett - Conrad Hunt
- Chris Ratz - Lisgar Gall
- Alex Poch-Goldin - Hubert Winston
- Natalie Roy - Liza
- Jeri Craden - Mrs. Merrick (as Jerelyn Craden)
- Shawn Campbell - Jefferey
- Steve Cumyn - Lawrence Braxton
- Sara Alicia Garcia - Ada Cunningham
- Katherine Fogler - Celia Quinlan
- Kyle Meagher - Boy
- Ewa Kasp - Marie Curie
- Richard Chevolleau - Charlie Pinsky
- Sabrina Grdevich - Dr. Almira Cotton
- Amelia Sargisson - Nancy Robinson
- Mikaela Bisson - Amy Wallace
- Patrick Stevenson - Delmar Ward
- Phillip Jarrett - Ozzie Beers
- Frank Moore - Jeb Cutler
- Mariah Inger - Fannie Robinson
- Andrew Hinkson - Amos Robinson
- Marie-Josée Colburn - Margaret Cutler
- Geraint Wyn Davies - Arthur Conan Doyle
- Mike Turner - Bob Sullivan
- Lindsey Connell - Jess Lacey
- Michael Rhoades - John Delaney
- Kate Trotter - Stella Smart
- Paul Miller - Arthur Wellesley
- David Christo - David Martin
- Corey Sevier - Horace Briggs
- James Downing - Coach Kane
- Christopher Cordell - Richard Hartley
- Jon Cor - Pearson
- Kent Staines - Owens
- Gavin Crawford - Harcourt
- Marilla Wex - Emmy Paulk
- Stephen Jackson - Stanley Paulk
- Eric Woolfe - Puppeteer
- Robert Dodds - Howard Rookwood
- Catherine Fitch - Flora Rookwood
- Jesse Bostick - Charlie
- Richard Howland - Miles Gorman
- Michael Riley - Doctor Burrit Greyson
- Stephen Bogaert - Richard Binney
- Jane Maggs - Emily Pringle
- Catherine McGregor - Katherine Barrington
- Robert Clarke - Andrew Nesbitt
- Roger Clown - Francis Grout
- Vincent Walsh - Eddie Cullen
- Robyn Thaler Hickey - Maggie Gilpatrick
- Michael Hanrahan - Daniel Gilpatrick
- Amber Cull - Ann Ryan
- Thomas Mitchell - Jake MacIsaac
- Grahame Wood - Kirk MacIsaac
- Robert Racki - Henri Gaston
- Genadijs Dolganovs - Professor Skrzhinsky
- Ian Downie - Farmer
- Kyle Mac - Trevor
- Kyle Mac - Daniel Irvine
- Joan Heney - Farmer's Wife
- Maurice Dean Wint - John Warton
- Ben Lewis - Teddy Jones Jr.
- Simon Northwood - Teddy Jones Sr.
- Bill Yak - Jaws McRawlins
- Michael Copeman - Lightning Wilcox
- Alastair Mackenzie - Inspector Edward Scanlon
- Katie Bergin - Olive Ross
- Molly Shanahan - Alberta Moffat
- Wendy Lyon - Melva Moffat
- Conrad Dunn - Professor Otranto
- Paul Haddad - Morris Bailey
- Sean Kaufmann - Lukas DeWitt
- London Angelis - Murdoch's boy
- Joris Jarsky - Leopold Romanow
- Duncan McLeod - Keating's Man
- Duncan McLeod - Roderick Grimesby
- Matt Baram - Edward Simms
- Matthew Edison - Paul Wilson
- Michael McMurtry - Arthur Webster
- Steven McCarthy - Dr. Isaac Tash
- Ian D. Clark - Dr. Ralph Fitch
- Vickie Papavs - Bertha Dunn
- Alex Paxton-Beesley - Lillie Dunn
- Rebecca Williams - Miss Binscarth
- Ted Atherton - Professor Albert Godfrey
- Paula Boudreau - Emily Richardson
- Elizabeth Saunders - Gracie Saunders
- Michael C. Newsome - Professor Samuel Bennett
- Kristen Holden-Ried - Prussian Kaspar Bomgaarts
- Gloria Slade - Mrs. Eason
- Keith Kemps - Ezra Delamore
- Bobby Prochaska - Blind Man
- Dixie Seatle - Mrs. Kitchen
- Peter Cockett - Hugo Brighouse
- Brian Frank - Joel Harris
- Anthony Bekenn - Travis Struthers
- Julie Lemieux - Parrot (voice)
- Tim Campbell - Gabriel Ryder
- Derek Moran - Nathan Siebold
- Jonathan Walker - Simon Goldberg
- Michael Bodnar - Jerzy Piezlowski
- Sam Malkin - Rabbi Dinitz
- Paul Amos - Dr. Roberts
- Sarah Allen - Enid Jones
- Paul Essiembre - Jacob Summers
- Hamish McEwan - Frank Jenson
- Charlotte Sullivan - Charlotte
- Charlotte Sullivan - Minerva Fairchild
- Duane Murray - Merrill Hardy
- Christine Brubaker - Mrs. Hardy
- Jeff Douglas - Reginald Poundsett
- Danny Cunningham - Eldon Fremont
- Sean Sullivan - Oscar Vanderlay
- Lisa Faulkner - Anna Fulford
- Patrick McKenna - Detective Hamish Slorach
- Andrew Musselman - Keating's Man
- Dylan Smith - Quentin Quinn
- Danny Lima - John Dawson
- Gabriel Hogan - Constable Randall Townsend
- Allan Royal - Chief Stockton
- Richard Clarkin - Inspector Davis
- Simon Sinn - Feng Choy
- Lee Rumohr - Constable Pete Holder
- Anthony Lemke - Father Clements
- Anthony Lemke - Henry Bixby
- Andrea So - Mei-Li
- Sergio Di Zio - Leonard Winters
- Zoe Cleland - Eva Rookwood
- Zoe Cleland - Joanne Perly
- Angela Vint - Miriam Winters
- Zoie Palmer - Katie Powers
- Mark Caven - Eugene Anderson
- Martin Doyle - Elias Boswell
- Billy MacLellan - Gunther Wenders
- Billy MacLellan - Enoch / Steven Hayes
- Billy MacLellan - Walter Lacey
- Kevin Dennis - Victor
- Gage Munroe - Bobby Brackenreid
- Philip Craig - Andrew Carnegie
- Philip Craig - Horace Mooney
- Ruth Goodwin - Amelia Richards (uncredited)
- Cynthia Preston - Sue Billingsley
- Ellie O'Brien - Andrea Porter
- Greta Onieogou - Themis
- Will Carr - Albert Jones
- Andrew Cromwell - Constable Lester Jope
- Percy Hynes White - Simon Brooks
- Sarah Booth - Abigail Prescott
- Daniel Kash - Arthur Frumm
- Daniel Kash - Randall Gordon
- Arcadia Kendal - Betty Fuller
- Christopher Heyerdahl - Jebediah Friessen
- Thom Allison - Oscar Ducharme
- Robin Wilcock - Front Desk Clerk
- Ari Millen - Agent Tanner
- Sean Baek - Mr. Aaron Park
- Kyle Gatehouse - Nigel Baker
- John Tench - Alexander Graham Bell
- Aaron Ashmore - Jack London
- Paula Brancati - Sophia Lucas
- Christopher Jacot - Roderick H. Roderick
- Christopher Jacot - Russell Chisholm
- Lauren Lee Smith - Elva Gordon
- Sharron Matthews - Marta Friessen
- Sharron Matthews - Miss Williams
- Erik Knudsen - Frank Rizzo
- Julian Richings - Phillip Uxbridge
- Russell Yuen - Jonathan Edwards
- Russell Yuen - Edward Chan
- Athena Karkanis - Dr. Iris Bajjali
- Salvatore Antonio - Luca Carducci
- Cara Ricketts - Rosina Denman
- Murry Peeters - Queenie Dowson
- Sarah Power - Clara Thorn
- Morgan Kelly - Wade Carson
- Lara Jean Chorostecki - Sydney Finch
- Wendy Crewson - Cassie Chadwick
- Tony Nappo - Dr. Gordon Bellows / Elijah Biggerstaff
- Tony Nappo - Mr. Hubert
- Bob Bainborough - Samuel Drainie
- Stuart Hughes - Dr. Anton Ridgeway
- Stuart Hughes - Charlie Appleby
- Stuart Hughes - Colonel Haywood
- Shauna MacDonald - Mrs. Billings
- Tara Nicodemo - Hannah
- Kimberly-Sue Murray - Hilda Gregson
- Paul Braunstein - Raymond Huckabee
- Paul Braunstein - Arlen Pike
- Jameson Kraemer - Detective Babcock
- Jameson Kraemer - Railway Boss
- Jefferson Brown - Lincoln Prescott
- Peter Outerbridge - Father Keegan
- Brandon Oakes - Uriah
- Jaeden Noel - Urchin
- Debra McGrath - Zinnia Hobson (as Deb McGrath)
- Gianpaolo Venuta - Herbert Wilson
- Sorcha Cusack - Hilda Fanshaw
- Juan Chioran - Atticus Jones
- Paul Popowich - Captain Roberts
- Geri Hall - Fiona
- Tricia Black - Penny
- Meher Pavri - Caroline
- Larry Day - Charlie Griffith
- Francis Melling - Anarchist
- Kenton Blythe - Rochester Cop
- Demetri Kellesis - Blake Redmond
- Lawrence Bayne - Gilbert Ward
- Will Corno - Mr. Williams
- Jeff Kassel - Quintin Crisp
- Brandon Knox - Bert
- Sydney Ozerov-Meyer - Clair Ferdinand
- George Masswohl - Henry Stanton
- George Masswohl - Cecil Vance
- Allan Hawco - Jacob Doyle
- Kimberly Huie - Wanda Feiss
- Spencer MacPherson - Lyle 'Junior' Anderson
- Jason Reso - Leonard Stoker
- Erin Agostino - Nina Bloom
- Michael A. Miranda - Giuseppe Falcone
- Hannah Cheesman - Mrs. Sachs
- Alicia Dea Josipovic - Kathleen Cooper
- Joy Tanner - Edith Frizzel
- Jajube Mandiela - Rose
- Em Siobhan McCourt - Maisie Bronson
- Tianna SwamiNathan - Maureen
- Matthew Lemche - William Price
- Don McCutcheon
- Cazhhmere Downey
- John L'Ecuyer
- Harvey Crossland
- Mars Horodyski
- Kelly Makin
- Michelle Ricci
- Mary Rogal-Black
- Janet McLean
- Graham Clegg
- Nisha Khan
- Larry Lalonde
- Scott Garvie
- Diane Kerbel
- Samantha McMillon
- Carol Hay
- Stephen Montgomery
- Paul Aitken
- David Horton
- Robert Carli
- Steve Hammond
Julian Richings interpreta a Phillip Uxbridge en la serie.
Yannick Bisson interpreta a Detective William Murdoch en la serie.
Erik Knudsen interpreta a Frank Rizzo en la serie.
Danny Cunningham interpreta a Eldon Fremont en la serie.
Rick Roberts hace el papel de Dr. Gilbert Birkins.
Sean Sullivan interpreta a Oscar Vanderlay en la serie.
William Shatner hace el papel de Mark Twain.
Stephen McHattie interpreta a Harry Murdoch en la serie.
Helene Joy interpreta a Dr. Julia Ogden en la serie.
Jonny Harris hace el papel de Constable George Crabtree.
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