- Laurie Mock - Female Alien
- Jerry Ayres - Groom
- Diane Baker - Kathy Adams
- Ellen Corby - Aunt Sara
- Vaughn Taylor - Kemper
- Skip Ward - Man
- Bonnie Beecher - Woman
- Roddy McDowall - Lloyd Lindstrom
- Willard Sage - Lieutenant James
- Dabbs Greer - The Minister
- Stuart Lancaster - Superintendent
- Soon-Tek Oh - Houseboy
- Mel Gallagher - Nurse
- Roy N. Sickner - Cab Driver
- Paul Gleason - Alien
- Edward Andrews - Evans
- Rodolfo Hoyos Jr. - Miguel
- Argentina Brunetti - Luz
- Roy Jenson - Alien
- Val Avery - Manager
- Ted Gehring - Cab Driver
- Pedro Regas - Beggar
- Tony Davis - Boy
- Roberto Contreras - Guide
- Pepe Callahan - Guide
- Diana Van der Vlis - Eve Doneghan
- Arthur Hill - Warren Doneghan
- Theo Marcuse - Noel Markham
- Peter Brocco - Millington
- Carol Eve Rossen - Selene Lowell
- Louise Latham - Joan Corman
- John Larch - Greg Lucather
- Frank Overton - Dr. Grayson
- Jonathan Goldsmith - Kevin Ryan
- Phillip Pine - Sgt. Hal Corman
- Danni Sue Nolan - Nurse
- Bill Erwin - Manager
- Jack Lord - George Vikor
- Joe Di Reda - Phil
- Larry Duran - Houseboy
- Max Kleven - Guard
- Craig Chudy - Alien
- Robert Emhardt - Oliver Ames
- Kathleen Widdoes - Ellen Woods
- Irene Tedrow - Clare Lapham
- Nellie Burt - Lena Lapham
- Logan Field - Carl Gidney
- Jeanette Nolan - Miss Havergill
- William Bramley - Constable Gabbard
- Jim Halferty - Fred Danielson
- Carey Loftin - Hank Braden
- William Challee - Danielson
- John Harmon - Cook
- Andrew Duggan - General Theodore Beaumont
- Robert Osterloh - Carl Wyeth
- Wesley Addy - Tomkins
- Lee Farr - Justice Department Agent
- Rick Murray - Parking Attendant
- David Armstrong - MP
- K.L. Smith - Guard
- Don Kennedy - Guard
- James Whitmore - Harry Swain
- William Talman - Colonel Griffith
- Milton Selzer - A.J. Richards
- Susan Strasberg - Diane Oberly
- Ernest Sarracino - Leo Rinaldi
- Mel Ruick - Minister
- Ron Doyle - Rescuer
- Raymond Guth - Guard
- Robert Doyle - Sgt. Walter Ruddell
- Paul Carr - Billy Stearns
- Erik Holland - MP Alien
- Harry Lauter - Alien
- Jack Warden - Barney Cahill
- Murray Matheson - Dr. Reynard
- Barry Russo - Lt. Alvarado
- John Ward - Alien Pilot
- John Ward - Trooper
- David Sheiner - Mr. Burns
- Clarke Gordon - Mr. Nova
- Paul Pepper - Dispatcher
- Garth Pillsbury - Intern
- Jacqueline Mayo - Sobbing Woman
- Ted Markland - Alien
- Tina Menard - Maid
- Tina Menard - Mama
- John Napier - Alien
- Laura Devon - Susan Carver
- Nancy Wickwire - Evelyn Bowers
- Norman Fell - Neal Taft
- Victor Brandt - Joey Taft
- Harold Gould - Allen Slater
- Harold Gould - Dr. Mailer
- Gilchrist Stuart - Waiter
- Garrison True - Doctor
- Bill Fletcher - Alien
- Ron Stokes - Alien at Controls
- Joseph Campanella - Father Joe
- Dean Harens - Dr. MacLeuen
- Carlos Romero - Luis Perez
- Hank Brandt - Man
- Hank Brandt - Joe Manners
- BarBara Luna - Lisa
- John McLiam - Hotel Clerk
- Edward Faulkner - Alien
- Robert Walker Jr. - Nick Baxter
- Lynn Loring - Madeline Flagg
- Joseph V. Perry - Joe Bagely
- Len Wayland - Deputy Wallace
- Helen Kleeb - Mollly
- Don Eitner - Webster
- William Stevens - Cobbs
- William Stevens - Sergeant
- Dabney Coleman - Capt. Mitchell Ross
- Dabney Coleman - John Carter
- Mercedes Shirley - Woman Attendant
- Peter Graves - Gavin Lewis
- William Wintersole - Alien
- William Wintersole - Carr
- John Ericson - Hardy Smith
- William Sargent - Dr. Ken Harrison
- William Sargent - Dr. John Devin
- Strother Martin - Charlie Coogan
- John Lupton - Maj. Clifford Banks
- Richard X. Slattery - Riley
- Paul Lukather - Correll
- John Carter - Owens
- Sam Edwards - Hank
- Sam Edwards - Thatcher
- Charles McDaniel - Roberts
- Ollie O'Toole - Reporter
- Steve Cory - Attendant
- Julie Sommars - Grace Vincent
- Diana Hyland - Ellie Markham
- Diana Hyland - Sherri Vikor
- Burgess Meredith - Theodore Booth
- Lloyd Gough - Joe McMullen
- Russ Conway - Detective Harding
- Laurence Naismith - Professor Lindstrom
- Laurence Naismith - Cyrus Stone
- Karen Norris - Miss Johnson
- Patricia Smith - Edna Greely
- Patricia Smith - Sally Palay
- Peggy Lipton - Bride
- Ralph Bellamy - Morgan Tate
- William Windom - Michael Tressider
- William Windom - Major Rick Graves
- Marlyn Mason - Carol Tate
- Lawrence Montaigne - Man
- Lawrence Montaigne - Garth
- Murray Hamilton - Lewis Dunhill
- Robert Knapp - Congressman Joe Bonning
- Robert Knapp - Lt. Col. Howell
- Wright King - Ed Tonkin
- Harlan Warde - Ed Peterson
- Paul Bryar - J.O. Brock
- Dallas Mitchell - Andy
- Dallas Mitchell - Jim Rogers
- James T. Callahan - Ed Gidney
- James T. Callahan - Dr. Harry Mills
- Larry Ward - Detective Carter
- Lew Brown - Aide
- Lew Brown - Non-Com in Charge
- Garry Walberg - Detective Reagan
- Kevin Burchett - Paul
- Gordon Wescourt - Joey
- Robert Sorrells - Station Attendant
- Robert Sorrells - Deputy Jim
- Debi Storm - Victoria
- Geoffrey Deuel - Teen
- J.D. Cannon - Police Lt. Ben Holman
- J.D. Cannon - Peter Kalter
- Stuart Nisbet - Coroner
- Seymour Cassel - Driver
- Antoinette Bower - Laurie Keller
- Jason Evers - Maj. Dan Keller
- Michael Rennie - Vice Chancellor Pierre Alquist
- Michael Rennie - Magnus
- Robert Brubaker - Gen. Winters
- Hal Baylor - Guard
- Hal Baylor - Friendly Guard
- Forrest Compton - Capt. Chester Albertson
- James Daly - Alan Landers
- James Daly - Gen. Samuel Arlington Concannon
- Burt Douglas - Capt. Burt Connors
- Roy Engel - Dr. Frederick Rogers
- Mort Mills - Mr. Arius
- Alfred Ryder - Mr. Nexus
- Alfred Ryder - Ryder (Invader Leader)
- Tom Palmer - Dorian
- Tom Palmer - Spence
- Anne Francis - Annie Rhodes
- Charles Drake - Robert Morrison
- Kelly Thordsen - Police Chief Sam Thorne
- Sandy Kenyon - Alien Leader
- Douglas Henderson - Lieutenant Farley
- Douglas Henderson - Martin
- Lin McCarthy - Col. Archie Harmon
- Lin McCarthy - Fellows
- Glenn Bradley - Doctor
- Ford Rainey - George Grundy
- Ford Rainey - Gen. Jonathan Blaine
- Noah Keen - Paul Meyers
- Noah Keen - Psychiatrist
- Shirley Knight - Margaret Cook
- Kevin McCarthy - Paul Cook
- Leonard Stone - Ramsey
- Robert Yuro - Simms
- John Mayo - Alien
- John Mayo - Weatherman
- Ed Begley - Dr. Samuel Crowell
- Ed Begley - Simon Carver
- Walter Brooke - Danvers
- Harry Hickox - Bowman
- James Seay - Grayson
- Paul Sorensen - Alien
- Don Ross - Ed Larson
- Don Ross - Reporter
- Mary Jackson - Nurse
- Mary Jackson - Hattie Willis
- Barney Phillips - Emmett Morgen
- Barney Phillips - Walt Anson
- Nan Martin - Dr. Maria McKinley
- Harry Townes - Will Hale
- Byron Morrow - Col. Newcomb
- Byron Morrow - Gilbert
- Ron Hayes - Sheriff Gordon Clements
- Mark Roberts - Dr. Sam Larousse
- Suzanne Pleshette - Vikki
- Suzanne Pleshette - Anne Gibbs
- James B. Sikking - Capt. William Taft
- Ted Knight - Alien Air Force Major McEvoy
- William Smithers - Nat Greely
- William Smithers - Adam Lane
- Jon Lormer - Minister
- Frank Marth - Alien
- Frank Marth - Eric H. Lund
- Claudia Bryar - Townswoman
- Katherine Justice - Helen
- Katherine Justice - Janet Garner
- Phil Chambers - Townsman
- Barbara Barrie - Gale Frazer
- Paul Mantee - Deputy Vern Hammond
- Richard Anderson - Blake
- Simon Scott - Dr. Malcolm Gantley
- Simon Scott - Maj. Pete Stanhope
- Simon Scott - Dr. John Slaton
- Peter Mark Richman - Tom Wiley
- Peter Mark Richman - Andrew Hatcher
- George Keymas - Lavin
- Allen Emerson - Organist
- Allen Emerson - Library Alien
- Russell Thorson - Sheriff
- Don Gordon - Charlie Gilman
- Russell Johnson - James Bernard
- Robert H. Harris - Hastings
- Robert H. Harris - Dr. Stanley Frederickson
- Lynda Day George - Janet Wilk
- Johnny Jensen - Frankie Reed
- Johnny Jensen - Young Nat
- Malcolm Atterbury - Judge Simonson
- Bill Zuckert - Sgt. Bert Wisnovsky
- John Rayner - Fred Wilk
- Richard Hale - Fred Wilk Sr.
- James McCallion - Brennan
- Selette Cole - Miss Cole
- Jason Wingreen - Court Clerk
- Amy Douglass - Mrs. Wilk
- Anthony Eisley - Bob Torin
- Anthony Eisley - Tony LaCava
- Sid McCoy - John Lovell
- Gene Hackman - Tom Jessup
- Mark Miller - Jack Palay
- John Randolph - Police Sgt. Ernie Goldhaver
- Wayne Rogers - Police Lt. John Mattson
- Noam Pitlik - Jerry Burns
- Christine Matchett - Elizabeth Garber
- Linden Chiles - Dr. Bob Vincent
- Linden Chiles - Jeremy Mace
- James Gammon - Hal
- Judee Morton - Mavis
- Kevin Coughlin - Roy
- Ray Kellogg - Guard
- Ray Kellogg - Policeman
- Vince Howard - Frank
- Brian Nash - Mike
- John S. Ragin - John Finney
- John S. Ragin - Kant
- Richard O'Brien - Police Sergeant
- Richard O'Brien - Brother John
- Richard O'Brien - Prof. Charles McKay
- Stephen Liss - Archie
- Joanne Linville - Angela Smith
- Joanne Linville - Prof. Pat Reed
- Byron Keith - Air Crash Investigator
- Byron Keith - Gen. Cullenbine
- Byron Keith - Brother James
- John Zaremba - General
- John Zaremba - Professor Ed Harrison
- Andrew Prine - Vern Corbett
- Whit Bissell - Col. Harris
- Joel Fluellen - Butler
- Joel Fluellen - Homer Warren
- Susan Davis - Mrs. James
- Ross Elliott - McNally
- Ross Elliott - Prof. Eliot Kramer
- Tim McIntire - Hal
- John Milford - Sheriff Lou Carver
- John Milford - James Boland
- John Milford - Jim Bryce
- Ross Hagen - Jorden
- Ross Hagen - Perry
- Tom Lowell - Steve
- Kelly Jean Peters - Nicole
- Michael Harris - Mail Truck Driver
- Walter Reed - Major
- Susan Oliver - Stacy
- Susan Oliver - Joan Seeley
- Ian Wolfe - Secretary Knute Rosmundson
- Ben Wright - Emissary
- Peter Hobbs - Colonel
- Martin West - Lieutenant
- Paul Comi - Danny
- Paul Comi - Police Sgt. Leeds
- R. G. Armstrong - Police Capt. Bill Battersea
- R. G. Armstrong - Gus Flagg
- Vic Perrin - Hypnotist Alien
- Don Lamond - Newsman
- Victoria Hale - Hippie
- William Boyett - Tressider's Man
- Rayford Barnes - Alien Deputy
- Rayford Barnes - Alien Driver
- Eduard Franz - Premier Thor Halvorsen
- Richard Eastham - Carl Vanders
- Albert Carrier - Frenchman
- Ed Asner - Taugus
- Ed Asner - Harry Ferguson
- Hank Simms - Journalist
- Morgan Jones - Guard
- Morgan Jones - Reporter
- Morgan Jones - Lt. Rawlings
- Pat Hingle - Brother Avery
- Kent Smith - Edgar Scoville
- Kent Smith - Stan Arthur
- Zina Bethune - Sister Claire
- Roger Perry - Bill Shay
- Dan Frazer - Reporter
- Sally Kellerman - Laura Crowell
- Virginia Christine - Mrs. Thorne
- Ed Peck - Darrow
- Martin Blaine - Argyle
- E.J. André - Dr. Henry Thorne
- Bill Quinn - Police Lieutenant Eaton
- Christopher Shea - Jimmy
- Christopher Shea - Johnny
- Barbara Dodd - Miss Fox
- Wilhelm von Homburg - Alien Patient
- William Sumper - Cab Driver
- Dana Wynter - Dr. Katherina Serret
- Don Dubbins - Wesley J. Sanders
- Fritz Weaver - Deputy Ambassador Peter Borke
- Lawrence Dane - Josef Dansk
- Peter Coe - Leo
- Robert Patten - Murphy
- Alex Rodine - Guard
- Carol Lynley - Elyse Reynolds
- Richard Karlan - Charles Roselli
- Warren Parker - Arthur Singeiser
- Rhys Williams - Professor Hellman
- Maura McGiveney - Mary Torin
- Kathleen Larkin - Lt. Sally Harper
- Than Wyenn - Torberg
- Gene Lyons - Sawyer
- Gene Lyons - John Corwin
- Mark Tapscott - Guard
- Ed Long - Corridor Guard
- Eddie Barth - Cab Driver
- Karen Black - Claudia Stone
- Troy Melton - Journalist
- Troy Melton - Chauffeur
- Ron Husmann - Sentry
- Karl Held - Lieutenant
- Nancy Kovack - June Murray
- Martin Wolfson - William Mace
- Donald Davis - Harland
- Donald Davis - Lucien
- John Lasell - Bob Ferrara
- John Stephenson - John Nivin
- Walter Woolf King - Head Alien
- Wayne Heffley - Deputy
- Wayne Heffley - Sergeant
- Michael Tolan - Dr. Ted Willard
- Michael Constantine - Dr. Martin Willard
- Charles Bateman - Burt Newcomb
- Booth Colman - Coroner Braemer
- Rose Hobart - Housekeeper - Irma
- Matt Pelto - Alien Clerk
- Lynn Hobart - Alien Nurse
- Ahna Capri - Joan Surrat
- Ken Lynch - Lieutenant Conners
- Pamela Curran - Louise
- Warren Vanders - Earl
- Don Chastain - Blake
- Ed Prentiss - Stanley Leeds
- Charles Stewart - Robertson
- Donald Harron - Jeff Brower
- Charles Aidman - Prof. Julian Reed
- Bartlett Robinson - Art Llewellan
- Lisabeth Field - Mrs. Fielding
- Pat O'Hara - Scientist
- Dort Clark - Security Officer
- Chris Robinson - Mike Calvin
- Nelson Olmsted - Amos Foster
- Larry Gates - Weller
- Roy Poole - Cort
- John Kellogg - Dom
- Barry Atwater - Dorcas
- Mark Allen - Second Mate
- Phyllis Thaxter - Sarah Concannon
- Pat Cardi - Bill Concannon
- Larry Thor - Dr. Bill Jacobs
- Jan Merlin - Post
- Craig Huebing - Willard
- Jack Bannon - Junior Officer
- Ed Deemer - Air Policeman
- Raymond St. Jacques - James A. Baxter
- Janet MacLachlan - Celia Baxter
- Roscoe Lee Browne - Arnold Andrew Warren
- Austin Willis - William Gehrig
- Louis Gossett Jr. - Ollie
- D'Urville Martin - Casey
- Pepe Brown - Michael Baxter
- Boyd 'Red' Morgan - Station Attendant
- Barbara Hershey - Beth Ferguson
- Arch Johnson - Father Paul
- Marion Thompson - The Nun
- Robert Biheller - Ricky
- Arthur Franz - Capt. Jim Trent
- Diana Muldaur - Claire
- Barry Morse - Keith
- Stephen Brooks - Officer Joe Nash
- Herb Armstrong - Doctor Stark
- Barry Cahill - Dorsey
- Will Geer - Hank Willis
- Dana Elcar - Sheriff Tom Halloway
- Michael McGreevey - Eddie McKay
- Eldon Quick - Antique Store Proprietor
- Barry Williams - Boy
- Stewart Moss - Hadley Jenkins
- Alex Gerry - Senator Robert Breeding
- Mary Gregory - Secretary
- Lee Millar - Reporter
- William Woodson - Narrator (voice) (uncredited)
- Hal Taggart - Juror (uncredited)
- Hal Taggart - Alien (uncredited)
- Hal Taggart - Pedestrian (uncredited)
- Ernest Harada - George - Waiter
- Marcia Wallace - Courtroom Spectator (uncredited)
- Lewis Allen
- Robert Glatzer
- Joseph Sargent
- John Meredyth Lucas
- Don Medford
- William Hale
- Howard Merrill
- Louis Vittes
- Robert Sherman
- Earl Hamner, Jr.
- Norman T. Herman
- Jerry Sohl
Larry Gates interpreta a Weller en la serie.
Vaughn Taylor hace el papel de Kemper.
R. G. Armstrong hace el papel de Police Capt. Bill Battersea.
Ken Lynch interpreta a Lieutenant Conners en la serie.
Leonard Stone interpreta a Ramsey en la serie.
Ralph Bellamy hace el papel de Morgan Tate.
Gene Hackman hace el papel de Tom Jessup.
Val Avery interpreta a Manager en la serie.
Pat Hingle hace el papel de Brother Avery.
Ian Wolfe interpreta a Secretary Knute Rosmundson en la serie.
Capítulo disponible en las siguientes plataformas:
