- Will Yun Lee - Marvelous Man
- Andy Milonakis - Phil Hart
- Edi Gathegi - Mr. Smiles
- Viggo Villalobos - Little Wing
- Jen Sung - Dr. Ravencroft
- Alexandra Billings - Alex
- Christopher Judge - President Nicholas E. Nukem
- RJ Mitte - Mind Master
- Adi Shankar - Logan Lockwood
- Adi Shankar - The Scottish Skull / Transatlantic Narrator
- Zachery Ty Bryan - Mike
- Alyson Stoner - Monica
- Max Adler - Samson Steel
- Christopher Gee - Cortrex (voice)
- Jessica Lee - Chandra Chang
- Victor Chi - Chuck Cody
- Hal Ozsan - Van Dawson
- Jenny Stumme - Secretary of Public Relations
- Richard Epcar - Blam Blam
- Perez Hilton - Blade Winston, Jr.
- Ryan Ochoa - Sepia Spider
- Ayman Samman - Arabic Reporter
- John Sweeney - Cop #2
- Claire Dodin - French Reporter
- Jeff Torres - Anubis Terrorist Leader
- Chaz Bono - Whittaker
- Ross Forte - Young Knight Hawk
- Hunter Daily - Miss Smirk
- Marc Barnes - The Accountant
- Anna Maria Horsford - Serena Lyle
- Jared Bell - Anubis Newscaster
- Jared Bell - Soldier 3
- Corey Clifford - Lockwood Heist Girl
- Candice Renee - Young Malina Lyle
- Chris Ready - Mind Master Henchman #2
- Eugene Alper - Boris Smiroff
- Guillermo Jorge - Cuban President
- Juzo Yoshida - Japanese Asian President
- Silvia Busuioc - Dasha
- Alena Savostikova - Sasha
- Cara Danielle Brown - Mr. Smiles Henchman
- Erick Geisler - Announcer
- Octavio Cruz - Business Man 2
- Lauren Daisy White
- Justin Smith
- Oscillian
Page Falkinburg Jr. interpreta a Knight Hawk en la serie.
Sharni Vinson interpreta a Speed en la serie.
Denise Richards interpreta a Laura Louis en la serie.
Derek Mears interpreta a Awesome Man en la serie.
John Hennigan interpreta a Red Talon en la serie.
Preeti Desai interpreta a Golden Goddess en la serie.
Tiffany Hines hace el papel de Black Bow.
Jackson Rathbone hace el papel de Blue Scream.
Kellan Lutz hace el papel de King Tsunami.
Will Yun Lee interpreta a Marvelous Man en la serie.
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