- Will Yun Lee - Marvelous Man
- Andy Milonakis - Phil Hart
- Edi Gathegi - Mr. Smiles
- Viggo Villalobos - Little Wing
- Jen Sung - Dr. Ravencroft
- Alexandra Billings - Alex
- Christopher Judge - President Nicholas E. Nukem
- RJ Mitte - Mind Master
- Adi Shankar - Logan Lockwood
- Adi Shankar - The Scottish Skull / Transatlantic Narrator
- Zachery Ty Bryan - Mike
- Alyson Stoner - Monica
- Max Adler - Samson Steel
- Christopher Gee - Cortrex (voice)
- Jessica Lee - Chandra Chang
- Victor Chi - Chuck Cody
- Hal Ozsan - Van Dawson
- Jenny Stumme - Secretary of Public Relations
- Richard Epcar - Blam Blam
- Perez Hilton - Blade Winston, Jr.
- Ryan Ochoa - Sepia Spider
- Ayman Samman - Arabic Reporter
- John Sweeney - Cop #2
- Claire Dodin - French Reporter
- Jeff Torres - Anubis Terrorist Leader
- Chaz Bono - Whittaker
- Ross Forte - Young Knight Hawk
- Hunter Daily - Miss Smirk
- Marc Barnes - The Accountant
- Anna Maria Horsford - Serena Lyle
- Jared Bell - Anubis Newscaster
- Jared Bell - Soldier 3
- Corey Clifford - Lockwood Heist Girl
- Candice Renee - Young Malina Lyle
- Chris Ready - Mind Master Henchman #2
- Eugene Alper - Boris Smiroff
- Guillermo Jorge - Cuban President
- Juzo Yoshida - Japanese Asian President
- Silvia Busuioc - Dasha
- Alena Savostikova - Sasha
- Cara Danielle Brown - Mr. Smiles Henchman
- Erick Geisler - Announcer
- Octavio Cruz - Business Man 2
- Lauren Daisy White
- Justin Smith
- Oscillian
Page Falkinburg Jr. hace el papel de Knight Hawk.
Sharni Vinson hace el papel de Speed.
Denise Richards interpreta a Laura Louis en la serie.
Derek Mears interpreta a Awesome Man en la serie.
John Hennigan hace el papel de Red Talon.
Preeti Desai interpreta a Golden Goddess en la serie.
Tiffany Hines interpreta a Black Bow en la serie.
Jackson Rathbone interpreta a Blue Scream en la serie.
Kellan Lutz interpreta a King Tsunami en la serie.
Will Yun Lee hace el papel de Marvelous Man.
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