- Maya Lynne Robinson - Geena Williams-Conner
- Matthew Broderick - Peter
- Sarah Chalke - Andrea
- Natalie West - Crystal Anderson
- Gina Brillon - Maria
- Kirk Fox - Creepy Guy
- Johnny Galecki - David Healy
- Justin Long - Neil
- Juliette Lewis - Blue
- Lindsey Kraft - Mrs. Reynolds
- Stephen Monroe Taylor - Dwight
- Artoun Nazareth - Pierre
- Tim Baltz - Wyatt
- Clark Gregg - Ron
- Jennifer Grey - Janelle
- Estelle Parsons - Beverly Harris
- James Pickens Jr. - Chuck Mitchell
- Patton Oswalt - Don Blansky
- Rene Rosado - Emilio
- Nancy Linehan Charles - Hannah
- Bud Galloway - Brian
- Linda Bisesti - Mrs. Tilden
- Katey Sagal - Louise
- Nat Faxon - Neville
- Jack Laufer - Steve
- Candice Bergen - Barb
- Brian Austin Green - Jeff
- Peter Gallagher - Brian Foster
- Phil Hendrie - Mr. Grayson
- Cheryl Texiera - Megan
- Jesse Gavin - Gil
- Paul Zies - Girl's Friend
- Paul Bates - Officer Whitcomb
- Blaise Miller - Young Man
- Xochitl Romero - Kat
- Ali Liebegott - Bridgette
- Paul Willson - Paulie
- M.C. Gainey - Group Leader
- Cassandra Relynn - Deaconess
- Seth Morris - Republican Man at Mall
- Rosie Moss - Democratic Woman at Mall
- David Paymer - Gary
- Marques Ray - Ramon
- Marques Ray - Bartender
- John Billingsley - Mr. Swindell
- Anne Bedian - Fatima
- Alain Ali Washnevsky - Samir
- Callan Farris - Kazim
- Elizabeth Phoenix Caro - Princess
- Mary Steenburgen - Marcy Bellinger
- Mauricio Lara - Enrique
- Ashton Pulis - Joey
- Bruno Oliver - Officer Roger
- Lucy Punch - Kyle's Mom
- Michael Chandler - Doctor
- Michelle Haro - Nurse Jeri
- Treisa Gary - Admittance Receptionist
- Jack Fisher - Austin
- Meagen Fay - Austin's Grandmother
- Dan Aykroyd - Buddy
- Joe Hursley - Barfly
- Molly Hawkey - Customer
- Lita Lopez - Nurse Joanna
- Eliza Bennett - Odessa
- Darlene Hunt - Gaby
- Patrick Fabian - James
- Judy Kain - Woman at Bar
- Mark Moseley - Football Announcer (voice)
- Paul Reubens - Sandy Bitensky
- Jenica Bergere - Officer Sharpe
- Chip Chinery - Tony
- Rodney J. Hobbs - Marty
- Paul McKinney - Will
- Vanessa Bell Calloway - Carrie Langham
- Billy Merritt - Santa Claus
- David Theune - Loan Broker
- Cheryl Hines - Dawn
- Sarah Baker - Helen
- Amos Blackmon - Parker
- Noel Fisher - Ed Conner Jr.
- Ozzy Osbourne - Self
- Sharon Osbourne - Self
- Denisse Ojeda - Sheila
- Rachel Hroncich - Customer
- Marlene Forte - Tia Elsie
- Blanca Araceli - Tia Ruthie
- Steve Agee - Tony
- Robin Romeo - Woman (voice)
- Paul Hipp - Zach
- Vincent M. Ward - Bouncer
- Kenzie Caplan - Marla
- Carmina Garay - Harper
- Jack Guzman - Officer Rodriguez
- Joel Murray - Jim
- David Pasquesi - Cyril
- Alison Segura - Maria
- Danny Trejo - Tito
- Eli Bildner - Sarcastic Guy
- Anna Maria Horsford - Nicole
- Evelina Fernández - Juanita
- Lori Hall - Wellman Co-Worker
- Phil Abrams - Dr. Davis
- Austin Boyce - Waitress
- Will Gressman - Priest
- Alexandra Billings - Robin Shetsky
- Betsy Baker - Carla
- Ivan Leung - Vet Assistant
- John Pirruccello - David Wellman
- Sonya Wallace - Security Guard
- Kat Purgal - Ms. Ruby
- Milo Manheim - Josh
- Timothy E. Goodwin - Hugh
- Emily Pendergast - Lisa
- Fred Savage - Dr. Harding
- Diahnna Nicole Baxter - Customer
- Mel Fair - Board Member
- Marie-France Arcilla - Doctor
- Darien Sills-Evans - Mike
- Danielle Harris - Molly Tilden
- Iris Bahr - Rachel
- Christopher Alvarenga - Carlos
- Helen Eigenberg - Jerri Lynn
- Mia Hunt - Patrice
- Carleton Bluford - Seth
- Aaron Rodgers - Self
- Echo Campbell - Student
- August Maturo - Student
- Tabitha Brown - Ann
- Jason Alexander - Pastor Phil
- Tony Cavalero - Aldo
- Nicholas Mongiardo-Cooper - Minister
- June Carryl - Joanne
- Timm Sharp - Gale
- Santino Barnard - Marvin
- Jaeden Bettencourt - Melvin
- Amanda MacDonald - Woman at Bookstore
- Chelsea Conwright - Lucy
- Heather Ann Gottlieb - Jess
- Aaron Colom - Customer
- Daniela Hernandez - Second Chancer
- Andrew Leeds - Nick
- Gabriella Baldacchino - Isabella
- Dwayne Colbert - Yard Sale Guy
- Andrea Anders - Helen
- Sachie Alessio - Heather
- Jared Farid Ward - Dr. Nash
- Joe Walsh - Jesse
- Marisa Brown - Laura
- Matt Walsh - Professor Glen
- Rodney To - Will Deetler
- Ryker Baloun - Tyler
- Chaize Macklin - Connie
- Bayne Gibby - Claire
- Angela Bullock - Libby Lewis
- Barry Rothbart - Marcus
- Jack Landron - Construction Crew Member
- James Wellington - Construction Crew Member
- John Gowans - Construction Crew Member
- Christopher Lloyd - Lou Vitore
- Jim O'Heir - Judge
- Ian Gomez - Father Morton
- Puddles Pity Party - Puddles
- Nick Offerman - Adam Chestnut
- Clare McNulty - Amanda
- Sean Astin - Tyler
- Lynn Andrews - Carla Rogers
- Jodi Harris - Ms. Ainsworth
- Gail Mancuso
- Jean Sagal
- Jody Margolin Hahn
- Lynda Tarryk
- Michael Arden
- Fred Savage
- Dave Caplan
- Jana Hunter
- Amy Fox
- Simone Finch
- Kimberly Altamirano
- Erica Montolfo-Bura
Christopher Lloyd interpreta a Lou Vitore en la serie.
Sean Astin interpreta a Tyler en la serie.
Paul Bates hace el papel de Officer Whitcomb.
Juliette Lewis interpreta a Blue en la serie.
Matthew Broderick hace el papel de Peter.
Mary Steenburgen interpreta a Marcy Bellinger en la serie.
Fred Savage hace el papel de Dr. Harding.
Jason Alexander interpreta a Pastor Phil en la serie.
Dan Aykroyd interpreta a Buddy en la serie.
Jennifer Grey interpreta a Janelle en la serie.
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