- Maya Lynne Robinson - Geena Williams-Conner
- Matthew Broderick - Peter
- Sarah Chalke - Andrea
- Natalie West - Crystal Anderson
- Gina Brillon - Maria
- Kirk Fox - Creepy Guy
- Johnny Galecki - David Healy
- Justin Long - Neil
- Juliette Lewis - Blue
- Lindsey Kraft - Mrs. Reynolds
- Stephen Monroe Taylor - Dwight
- Artoun Nazareth - Pierre
- Tim Baltz - Wyatt
- Clark Gregg - Ron
- Jennifer Grey - Janelle
- Estelle Parsons - Beverly Harris
- James Pickens Jr. - Chuck Mitchell
- Patton Oswalt - Don Blansky
- Rene Rosado - Emilio
- Nancy Linehan Charles - Hannah
- Bud Galloway - Brian
- Linda Bisesti - Mrs. Tilden
- Katey Sagal - Louise
- Nat Faxon - Neville
- Jack Laufer - Steve
- Candice Bergen - Barb
- Brian Austin Green - Jeff
- Peter Gallagher - Brian Foster
- Phil Hendrie - Mr. Grayson
- Cheryl Texiera - Megan
- Jesse Gavin - Gil
- Paul Zies - Girl's Friend
- Paul Bates - Officer Whitcomb
- Blaise Miller - Young Man
- Xochitl Romero - Kat
- Ali Liebegott - Bridgette
- Paul Willson - Paulie
- M.C. Gainey - Group Leader
- Cassandra Relynn - Deaconess
- Seth Morris - Republican Man at Mall
- Rosie Moss - Democratic Woman at Mall
- David Paymer - Gary
- Marques Ray - Ramon
- Marques Ray - Bartender
- John Billingsley - Mr. Swindell
- Anne Bedian - Fatima
- Alain Ali Washnevsky - Samir
- Callan Farris - Kazim
- Elizabeth Phoenix Caro - Princess
- Mary Steenburgen - Marcy Bellinger
- Mauricio Lara - Enrique
- Ashton Pulis - Joey
- Bruno Oliver - Officer Roger
- Lucy Punch - Kyle's Mom
- Michael Chandler - Doctor
- Michelle Haro - Nurse Jeri
- Treisa Gary - Admittance Receptionist
- Jack Fisher - Austin
- Meagen Fay - Austin's Grandmother
- Dan Aykroyd - Buddy
- Joe Hursley - Barfly
- Molly Hawkey - Customer
- Lita Lopez - Nurse Joanna
- Eliza Bennett - Odessa
- Darlene Hunt - Gaby
- Patrick Fabian - James
- Judy Kain - Woman at Bar
- Mark Moseley - Football Announcer (voice)
- Paul Reubens - Sandy Bitensky
- Jenica Bergere - Officer Sharpe
- Chip Chinery - Tony
- Rodney J. Hobbs - Marty
- Paul McKinney - Will
- Vanessa Bell Calloway - Carrie Langham
- Billy Merritt - Santa Claus
- David Theune - Loan Broker
- Cheryl Hines - Dawn
- Sarah Baker - Helen
- Amos Blackmon - Parker
- Noel Fisher - Ed Conner Jr.
- Ozzy Osbourne - Self
- Sharon Osbourne - Self
- Denisse Ojeda - Sheila
- Rachel Hroncich - Customer
- Marlene Forte - Tia Elsie
- Blanca Araceli - Tia Ruthie
- Steve Agee - Tony
- Robin Romeo - Woman (voice)
- Paul Hipp - Zach
- Vincent M. Ward - Bouncer
- Kenzie Caplan - Marla
- Carmina Garay - Harper
- Jack Guzman - Officer Rodriguez
- Joel Murray - Jim
- David Pasquesi - Cyril
- Alison Segura - Maria
- Danny Trejo - Tito
- Eli Bildner - Sarcastic Guy
- Anna Maria Horsford - Nicole
- Evelina Fernández - Juanita
- Lori Hall - Wellman Co-Worker
- Phil Abrams - Dr. Davis
- Austin Boyce - Waitress
- Will Gressman - Priest
- Alexandra Billings - Robin Shetsky
- Betsy Baker - Carla
- Ivan Leung - Vet Assistant
- John Pirruccello - David Wellman
- Sonya Wallace - Security Guard
- Kat Purgal - Ms. Ruby
- Milo Manheim - Josh
- Timothy E. Goodwin - Hugh
- Emily Pendergast - Lisa
- Fred Savage - Dr. Harding
- Diahnna Nicole Baxter - Customer
- Mel Fair - Board Member
- Marie-France Arcilla - Doctor
- Darien Sills-Evans - Mike
- Danielle Harris - Molly Tilden
- Iris Bahr - Rachel
- Christopher Alvarenga - Carlos
- Helen Eigenberg - Jerri Lynn
- Mia Hunt - Patrice
- Carleton Bluford - Seth
- Aaron Rodgers - Self
- Echo Campbell - Student
- August Maturo - Student
- Tabitha Brown - Ann
- Jason Alexander - Pastor Phil
- Tony Cavalero - Aldo
- Nicholas Mongiardo-Cooper - Minister
- June Carryl - Joanne
- Timm Sharp - Gale
- Santino Barnard - Marvin
- Jaeden Bettencourt - Melvin
- Amanda MacDonald - Woman at Bookstore
- Chelsea Conwright - Lucy
- Heather Ann Gottlieb - Jess
- Aaron Colom - Customer
- Daniela Hernandez - Second Chancer
- Andrew Leeds - Nick
- Gabriella Baldacchino - Isabella
- Dwayne Colbert - Yard Sale Guy
- Andrea Anders - Helen
- Sachie Alessio - Heather
- Jared Farid Ward - Dr. Nash
- Joe Walsh - Jesse
- Marisa Brown - Laura
- Matt Walsh - Professor Glen
- Rodney To - Will Deetler
- Ryker Baloun - Tyler
- Chaize Macklin - Connie
- Bayne Gibby - Claire
- Angela Bullock - Libby Lewis
- Barry Rothbart - Marcus
- Jack Landron - Construction Crew Member
- James Wellington - Construction Crew Member
- John Gowans - Construction Crew Member
- Christopher Lloyd - Lou Vitore
- Jim O'Heir - Judge
- Ian Gomez - Father Morton
- Puddles Pity Party - Puddles
- Nick Offerman - Adam Chestnut
- Clare McNulty - Amanda
- Sean Astin - Tyler
- Lynn Andrews - Carla Rogers
- Jodi Harris - Ms. Ainsworth
- Gail Mancuso
- Jean Sagal
- Jody Margolin Hahn
- Lynda Tarryk
- Michael Arden
- Fred Savage
- Dave Caplan
- Jana Hunter
- Amy Fox
- Simone Finch
- Kimberly Altamirano
- Erica Montolfo-Bura
Christopher Lloyd interpreta a Lou Vitore en la serie.
Sean Astin interpreta a Tyler en la serie.
Paul Bates hace el papel de Officer Whitcomb.
Juliette Lewis interpreta a Blue en la serie.
Matthew Broderick interpreta a Peter en la serie.
Mary Steenburgen interpreta a Marcy Bellinger en la serie.
Fred Savage hace el papel de Dr. Harding.
Jason Alexander hace el papel de Pastor Phil.
Dan Aykroyd hace el papel de Buddy.
Jennifer Grey interpreta a Janelle en la serie.
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