- Carroll O'Connor - Gus Stemple
- Janeane Garofalo - Mabel Buchman
- Florence Stanley - Miriam Sass
- Ed Asner - Zigmund Klarik
- Art Evans - Ike
- Robin Bartlett - Debbie Buchman
- Mary Matalin - Mary Matalin
- Mel Brooks - Uncle Phil
- Jeff Garlin - Marvin Bluestone
- Cara DeLizia - Teenager Mabel Buchman
- Simon Templeman - Martin
- Charles Shaughnessy - Michael
- Steve Buscemi - Howie Balinger
- Gregory Paul Martin - Andrew
- Larry Hankin - Bob the Security Guard
- Andrea Elson - Joanne
- Jerry Hardin - Al
- Max Wright - Man in Elevator
- Darcy DeMoss - Mindy
- Erick Avari - Dr. Arzupian
- Parley Baer - The Husband
- Bob Sheppard - Announcer
- Richard Belzer - Detective Sharp
- Bradley Pierce - Jed
- Estelle Getty - Aunt Ida
- Randy Graff - Sharon, Paul's Elder Sister
- Rhea Perlman - Mrs. Ramona DiChristophoro
- Marsha Warfield - Birth Instructor
- Sam Lloyd - Cousin David
- Logan O'Brien - Boy on Street
- Eileen Brennan - Inspector #10
- Nancy Dussault - Theresa Stemple
- Craig Bierko - Gardner Mulloy
- Meredith Bishop - 18 Year-Old Mabel
- James Cameron - James Cameron
- Bruno Kirby - Virgil
- Anne-Marie Johnson - Pre-School Principal
- Melinda McGraw - Cheryl Gendelman
- Will Rothhaar - Logan
- Jodi Carlisle - Saleslady
- Jean Louisa Kelly - Diane the Nurse
- Rebecca Lobo - Rebecca Lobo
- Franklin Cover - Yankee Infielder
- Ken Jenkins - Jack Farrer
- Carolyn Mignini - Bank Manager
- Bruce Willis - Bruce Willis
- Eugene Levy - Doctor
- Mark McGwire - Mark McGwire
- Barbara Feldon - Diane 'Spy Girl' Caldwell
- Michael Buffer - Announcer
- Alex Trebek - Alex Trebek (voice)
- Christie Brinkley - Christie Brinkley
- Richard Kind - Dr. Mark Devanow
- Kerri Green - Stacey
- Carol Burnett - Theresa Stemple
- Sydney Pollack - Dr. Sydney Warren
- Sylvester Terkay - Amish Hellcat
- Jack Hallett - Babyproofer
- Robert Klein - Stan Freitus
- Gary Grossman - Guy in Gym
- Kim Hunter - Millie Barton
- Paxton Whitehead - Hal Conway
- Jerry Adler - Mr. Wicker
- Jerry Adler - Sgt. Panino
- Steven Wright - Warren Mermelman
- Lewis Black - Pizza Slice
- Judy Geeson - Maggie Conway
- Allan Arbus - Albert Urbont
- John Astin - John Astin
- Jerry Lewis - Freddy Statler
- Louis Guss - Mel Wertzel
- Anthony Russell - Dispatcher
- Larry Miller - Lou Bonaparte
- Keone Young - Al
- Regis Philbin - Regis Philbin
- Richard Benjamin - Mr. Frank DiChristophoro
- Beata Pozniak - Masha
- Aria Noelle Curzon - Shania
- Rita Wilson - Lindsay Krbnsk
- Beau Billingslea - The Security Chief
- Suzie Plakson - Dr. Joan Golfinos
- John Fleck - Ricky
- Al Ruscio - Uncle Jules
- Missi Pyle - Beautiful Woman
- Julia Sweeney - French Professor
- Estelle Harris - Barry's Mother
- Paul Dooley - Gus Stemple
- Amy Hill - Police Officer
- Mark Schiff - Max
- Mark Schiff - Leo
- Rick Rossovich - Sherman Williams
- Kim Chan - Maitre'd
- Andre Agassi - Andre Agassi
- Perry Anzilotti - Roy Osterback
- Rick Overton - Shepherd
- Mo Gaffney - Dr. Sheila Kleinman
- John Michael Higgins - Patrick
- Patty Toy - Tammy
- Mare Winningham - Sarah McCain
- David Koechner - Store Clerk
- Stephen Tobolowsky - Principal Hocksacker
- Joy Philbin - Joy Philbin
- Jesse D. Goins - DiChristophoros' Lawyer
- Seth Green - Bobby Rubenfeld
- Dick O'Neill - Manny Barton
- Abe Vigoda - Kalman Wertzel
- Earl Billings - Security Guard
- Bill Erwin - Yankee Third Baseman
- Talia Balsam - Debbie
- James Carville - James Carville
- Garth Brooks - Garth Brooks
- Jamie Farr - Dry Cleaner
- Ana Gasteyer - Yoga Woman
- Billy Joel - Billy Joel
- Jack Kenny - Waiter
- Randy Poffo - Randy Savage
- J.D. Daniels - Edward Wagner
- Lisa Kudrow - Ursula Buffay
- Lisa Kudrow - Karen
- Kenneth Tigar - Norman Lark
- Lili Taylor - Arley
- Luis Antonio Ramos - Juan
- Rodney Van Johnson - Park Ranger
- Ralph Manza - Campanella
- Ralph Manza - Saul
- Judyann Elder - Nurse Lily
- Bill Henderson - Mets Shortstop
- Edie McClurg - Rosie
- Dan Castellaneta - Rory O'Grady
- Michael Richards - Cosmo Kramer
- Kyle Sullivan - Little Boy
- Stephanie Bellars - Macho's Valet
- Robert Curtis Brown - Lawyer
- Lisa Edelstein - Lynne Stoddard
- David Arnott - Lester
- Ellen DeGeneres - Nancy Bloom
- Eric Stoltz - Alan Tofsky
- Tim Conway - Clerk / Justice of Peace
- Chuck McCann - Mets Catcher
- Maria Pitillo - Mimi
- Jennifer Darling - Cassie Bluestone
- Jack Brewer - Parcel Guy
- Stuart Pankin - Mr. Brodsky
- Fred Willard - Henry Vincent
- Dean Cameron - Irwin
- Lenny Wolpe - Monty
- Megan Mullally - Jane
- Lyle Lovett - Lenny
- Saverio Guerra - Bellhop
- Elena Wohl - Ellen
- Daniel Hagen - Skip
- Dena Dietrich - Mrs. Michalak
- Michael Moore - Michael Moore
- David Dunard - Dan the Cop
- Dylan Haggerty - Young Man in 6C
- Valente Rodriguez - Harold the Orderly
- Tommy Hinkley - Jay Selby
- Brian McNamara - Doug
- Lisa Waltz - Didi
- Gilbert Gottfried - Spanky's Master
- Fred Stoller - Mischa's Master
- Joyce Guy - The Nurse
- Bob Amaral - The Furniture Worker
- Jim Piddock - Hal Conway
- Jim Piddock - Logic Professor
- Monica Allison - Sycophant
- Yoko Ono - Yoko Ono
- John F. O'Donohue - Ernest
- John Capodice - Bill
- Willie Garson - Randall
- Kathy Griffin - Brenda
- Bridget Sienna - Mrs. Velasquez
- Tino Insana - Sanitation Guy
- Linda Porter - Mark's Elderly Patient
- Dick Clark - Dick Clark
- Eric Christmas - Bernard
- Wendle Josepher - The Assistant
- Wayne Wilderson - Bank Executive
- Alexandra Bokyun Chun - Cassandra (Gift Wrapping Clerk)
- Daniel Chodos - Cab Driver Executive
- Paunita Nichols - The Mother
- Edward Hibbert - Maitre D'
- Cady Huffman - Barking Woman
- F.X. Vitolo - Jimmy, Newsdealer
- Tony Conforti - Newsdealer
- Billye Ree Wallace - The Sweet Little Woman
- Kellen Hathaway - Tuba Boy
- Jon Polito - Ralphy
- Gareth Williams - Mikey
- April Ortiz - Mother
- Larry Romano - Vinnie
- Robert Dorfman - Counterman
- Anthony Backman - Comic Book Patron (uncredited)
- Patrick Ewing - Patrick Ewing
- Cyndi Lauper - Marianne Lugasso
- Caroline Aaron - Trish Dawson
- Pamela Dunlap - Louise
- Dominic Hoffman - Waiter
- John C. Moskoff - Sam Frank
- Annie Korzen - Fritzi Frank
- Gregg Daniel - Neighbor
- Mark Tymchyshyn - Boat Attendant
- William Mesnik - Bowling Guest
- Michael Lembeck - Mr. Shapiro (uncredited)
- Clea Lewis - Salesperson
- Nancy Lenehan - Dr. Wallach
- John O'Leary - Mr. Howard
- Pierre Gonneau - Mr. Boniello
- Michael Leopard - Passenger
- Debra Mooney - Sister Dorothea
- Carlos Ferro - Snappy Garment Man
- Carl Reiner - Alan Brady
- Richard Frank - Director
- Alix Elias - TV Wife
- Tom Gallop - Ad Exec
- William Utay - Maitre'D
- Rachel Hunter - Rachel Hunter
- Jay Leno - Jay Leno
- Bill Saluga - Racing Fan
- Bill Saluga - Mr. Fefvil
- Brent Spiner - Bob, the Dog Agent
- Vito Scotti - Antonio
- David Strickland - Hollis Pavel
- David Strickland - Sycophant
- Kirsten Holmquist - Dancer
- Marva Hicks - Remy
- Nancy Fish - The Receptionist
- Leland Orser - Professor Gittleson
- Marita Geraghty - Velma
- Armando Molina - The Delivery Guy
- Richard Redlin - Frank
- Jim Lau - Ng Lieu Cho
- Iqbal Theba - Cabbie
- Otto Coelho - The Homeless Man
- Jane Carr - Hillary
- Bibi Osterwald - Older Woman
- Patrick Cronin - Postal Worker
- George D. Wallace - Projectionist
- Anne Bobby - Susannah
- Eric Lutes - Mick
- David Steinberg - Director
- David Steinberg - Bad Eulogizer
- Allan Wasserman - Lawyer
- Kelly Perine - Man in Line
- June Gable - Woman
- Gates McFadden - Allison Rourke
- Rudolph Giuliani - Rudolph Giuliani (uncredited)
- Henry Gibson - Henry Gibson
- Tony Edwards - Optician
- Tony Edwards - Man in the Store
- Arte Johnson - Arte Johnson
- Gary Owens - Gary Owens
- Jo Anne Worley - Jo Anne Worley
- Frank Birney - The Waiter
- Chick Vennera - Johnny
- Robert Costanzo - Door Guy
- Wendie Malick - Carol
- Michael Yama - The Dealer
- Vince Grant - Bob
- Penny Fuller - Theresa Stemple
- John Karlen - Gus Stemple
- Andrew Gold - Seedy Guy
- Ping Wu - Kim
- Judith Hoag - Doris
- Meg Wyllie - Aunt Lolly Stemple
- Senait Ashenafi - Tracy
- Jack Shearer - Manny Ganz
- Joe Flood - Cabbie
- Liz Georges - Mother
- Erin Trimble - Little Girl
- Brian Jensen - Soap Actor
- Kevin Michael Richardson - Cable Man
- Pat Crawford Brown - Neighbor
- Stan Sellers - Neighbor
- Al Roker - Al Roker (uncredited)
- Charles Hallahan - 'Sloopy' Dunbar
- Wendy Hammers - Woman Shopping for Golf Clubs
- Anita Gillette - Claire Wicker
- Michael Tomlinson - Man Looking for Fishing Rod
- Kristen Cloke - Salesperson
- Ernie Sabella - Maurice
- Dana Lee - Mike
- Al Berry - Racing Fan
- Danny Mora - Racing Fan
- Bill Phillips Murry - Racing Fan
- Mario Roccuzzo - Racing Fan
- Susie Coelho - Woman
- Tyrees Allen - Bobby
- Tyrees Allen - Party Guest
- Roger Rignack - Dave (uncredited)
- Hank Azaria - Nat Ostertag
- Fabiana Udenio - Sophia
- Pierrino Mascarino - Giuseppe
- Richard Portnow - Arthur
- Tiffany Taubman - The Little Girl
- John C. McDonnell - The Barfly
- Alan Ruck - Lance Brockwell
- Kathleen Wilhoite - Iris
- James Lesure - Maitre 'D
- Brad Garrett - The Nurse
- Vic Polizos - The Truck Driver
- Wesley Thompson - The Man in the Hospital
- Chris Bonno - Man at the Counter
- Julian Stone - Dr. Griffin
- Ted Sorel - Boardroom Executive
- Karen Maruyama - O.R. Nurse
- Tohoru Masamune - Anesthesiologist
- Sherman Howard - Explorer Channel Executive
- Amzie Strickland - Woman Customer
- Sofia Milos - Sarah
- Bradley White - Doug Berkus
- Frederika Kesten - The Karaoke Waitress
- Peggy Mannix - The Kissing Woman
- Billy Morrissette - Sanford Klarik
- Susan Ilene Johnson - Party Guest #1
- Peter Dach - Party Guest #2
- Peter White - Judge Chuffa
- Shecky Greene - Uncle Marty
- Len Lesser - Uncle Arnold
- Richard Roat - Phillip
- Sarah Partridge - Audrey, who slaps Selby
- Spencer Klein - Ryan Devanow
- Phil Leeds - Vacky
- George Petrie - Sid
- George Petrie - Elevator Operator
- Michael Goldfinger - Male Passenger
- Elizabeth Norment - Female Passenger
- Steven M. Porter - Husband
- Andrew Craig - Sisters of Charity Mover
- Andrew Craig - Al Spehr
- Phill Lewis - Jim Weaver
- Phill Lewis - Jason Disbrow
- Toshi Toda - Businessman
- Carol Ann Susi - Female Passenger
- Michael Fairman - Conductor
- Wayne Tippit - Manny Gantz
- E.J. Callahan - Gentleman
- E.J. Callahan - Celtic Fan
- Kathryn Spitz - Dana
- Bill Dunleavy - The Big Apple
- Albert Owens - The Cat
- Murphy Dunne - Ned
- William Newman - The Waiter
- Annie Abbott - Friendly Woman
- Neil Vipond - Friendly Man
- Laura Waterbury - Guest #1, Looking for Her Hat
- Patrick Bristow - Troy
- Patrick Bristow - The Clerk
- Patrick Warburton - Sam
- Meagen Fay - Connie
- Bill Fox - Belden
- Donna Pieroni - Masseuse
- Lou Cutell - Eddie
- Phil LaMarr - Marshall
- David Ellzey - Saul Beckner
- Nancy Kerr - Janey Beckner
- Francesca P. Roberts - Nurse
- Cameron Thor - Rick
- Susan Blommaert - Rita, the Cabby
- Susan Blommaert - Miss Grundy
- Marjorie Wellin - Waitress
- Aaron Lustig - Neighbor in 9-D
- Ron Frazier - Museum Guard
- Ralph Bruneau - Jim
- Lyndsay Riddell - Young Jamie
- Steve Paymer - Dutch
- Steve Paymer - Russell Bernard (voice)
- Shirley Prestia - Tourist
- Ryan Stiles - Video Vogue Manager
- Ryan Stiles - Boss
- Patrick Neil Quinn - Gambler
- Robert Donley - Scat King
- Race Nelson - Handsome ATM Man
- Greg Collins - Sergio
- Lynn Milgrim - Maid
- Timi Prulhiere - Young Woman in 6C
- Marty Rackham - Phone Repair Man
- Adilah Barnes - Registrar
- Lightfield Lewis - 'Fresh Vomit' Fan
- Stephen Pearlman - Ethics Professor
- Mary Portser - Psych Professor
- Daryl Keith Roach - Photographer
- Alan Wilder - Registrar
- Ivory Ocean - Issac
- David Berón - Nick
- Karla Tamburrelli - Mrs. Astin
- Darrell Kunitomi - Kim
- Jimm Giannini - Hot Dog Vendor
- Andrew J. Ferchland - Noah
- Joe Costa - Klarik's Customer
- Harry S. Murphy - Pedestrian
- Ann Hamilton - Dateline Assistant
- John O'Hurley - Dr. VonDerphal
- Victoria Hoffman - Victoria, Ira's Girlfriend
- Jann Karam - Donut Lady
- Norma Maldonado - Consuela the Maid
- Harry Groener - Lance Brockwell
- Arnetia Walker - Jamie's Co-Worker
- Gedde Watanabe - Speech Writer
- Elya Baskin - Vladimir
- Nick Toth - Kinko's Customer
- John H. Freeland Jr. - Worker
- Kenneth Moskow - Paul's Cameraman
- Alan Charof - Cousin Herb Buchman
- Christopher Darga - Akiba the Cameraman
- Allan Corduner - Osofsky
- Floyd Levine - Artie Zeitlin
- Adam Weisman - Young Paul
- Zane Lasky - Irwin the Storekeeper (1964)
- Kevin Bacon - Kevin Bacon
- José Zúñiga - Arturo the Hairdresser
- Carol Rosenthal - Deejay
- Joanna Daniels - Woman in Elevator
- Alex Rocco - Mel Slotkin
- Dorothy Patterson - Mrs. Gruber
- Paul Parducci - Dante
- John Toles-Bey - Homeless Guy
- Alfonso De Rose - Italian Guy
- Elizabeth LaRou - Gym Clerk
- Kari Coleman - Molly Norman
- Roger Behr - Narrator
- Danny Breen - Narrator
- Marcus Smythe - Mellifluous Voice
- Jeanne Mori - Campaign Worker
- Scott Atkinson - Doug the Handyman
- Vasili Bogazianos - Security Agent
- Melanie Mayron - Dorie the Astrologist
- Steven Gilborn - Professor Tomassi
- Roy Fegan - Klarik's Manager
- Dale Godboldo - Film Student
- Fritzi Burr - Klarik's Customer
- Lawrence Mandley - Leon, Orderly
- Eric Allan Kramer - Skippy, Orderly
- Ann Walker - Receptionist
- Sid Caesar - Uncle Harold
- Jill C. Klein - Aunt Blossom
- Frederick de Cordova - Hugh Moss
- Franc Ross - Suit
- Harley Zumbrum - Suit
- Mark Nutter - Suit
- Phyllis Lyons - Darla
- Markus Redmond - Dr. Kekitch
- Markus Redmond - Howard the Storekeeper (1996)
- Stacey Travis - Dawn
- Scott Jaeck - Pool Player from A.A.
- Greg Lee - Pool Player
- Tom Hodges - Pool Player
- Harper Roisman - Gas Attendant
- John David Conti - Bartender
- Fred Sanders - Pet Shop Owner
- Deborah Theaker - Judy Kaufman
- David Vegh - Crew Guy
- Kevin Keckeisen - Little Boy
- Jean St. James - Mother
- Greg Longstreet - Grocery Clerk
- Aaron Aames - Pregnant Man
- Zaid Farid - Cop
- Sergey Brusilovsky - Cabbie
- Gerry Bednob - Cabbie
- Kevin Contreras - Man in Birthing Class
- Mary Anne Schafer - Woman in Birthing Class
- Joe Alfasa - Oscar the Doorman
- Golde Starger - Woman
- Cynthia Frost - Woman
- Danny Dayton - Old Man
- David Fresco - Old Man
- Mailon Rivera - Ray
- Leon W. Grant - Jeff
- John Gegenhuber - Dr. Ben
- Alison Martin - Muriel
- Lance E. Nichols - Dr. Eckstein
- Anthony Mangano - The Orderly
- James Martin Jr. - Man
- Jack Esformes - The Crew Guy
- Penny Griego - The Reporter
- Rita Gomez - The Spanish Woman
- Jeff Cahill - Keanu the Cabbie
- Nick Jameson - Belgian Man
- Elea Oberon - Belgian Woman
- David Basulto - Cop
- Bernard Hocke - Tatoo Artist
- Beans Morocco - Court Bailiff
- Sydney Bennett - Roberta
- Helen Geller - Pirate Maiden
- Shannon Welles - Pirate Maiden
- Allen Bloomfield - Pirate
- Michael Perrotta - Pirate
- Mark Sheeler - Pirate
- David Batiste - Slippy's Boyfriend
- Lawrence B. Adisa - Theresa's Boyfriend
- Marcelo Tubert - Subway Passenger
- Mona Leah - Dancer
- Charlie Brumbly - Dancer
- Deena Grassia - Dancer
- Mark Meismer - Dancer
- Keith Kuhl - Dancer
- Eric Steele - Dancer
- J.T. Horenstein - Dancer
- Denise Holland - Dancer
- Nathan Lane - Nathan Twilley
- Jadili Johnson - Student
- JoNell Kennedy - Paul's Flight Attendant
- Hiram Kasten - Leon
- Maria Stanton - Jamie's Flight Attendant
- Vanessa Lock - Flight Attendant
- Patricia Place - Annoyed Passenger
- Steven Anderson - Ricky Wrongstag
- Mary Gallagher - Lobbyist
- Joanna Sanchez - Lobbyist
- Donna Ponterotto - Waitress
- Darlene Kardon - Svetlana Poszinsky
- Fred Pinkard - Yankee Catcher
- Murray Rubin - Al Birnbaum
- Carole Goldman - Irate Fan
- Mark Pitta - Announcer
- Eliza Coyle - Molly - Ira's Girlfriend
- Ron Karabatsos - Barney Kraft
- Matt Kaminsky - Steve the Waiter
- Brooke Marie Bridges - Brooke
- David Carpenter - Man on Street
- Bonita Friedericy - Bonita
- Nicolette Little - Nicolette
- Mark Harrison - Dr. Hill
- Joey Dente - Astrovision Clerk
- Ernie Vincent - The Chef
- Gordon Hunt - TV Host
- Helen Siff - Female Teacher
- Ajgie Kirkland - Male Teacher
- Heidi Kaufman - Girl from Cleveland
- Nancy Bell - Barbara
- Steven Hack - Maynard the Editor
- Sean Smith - Guy in Absurd Sweater
- Christopher Randolph - Office Worker
- David Patrick Kelly - Cabbie with Chicken
- Adam Dannheisser - Man with Cellphone
- Michael Mulheren - Rude Man
- Jeanmarie Evans - Slapping Lady
- Skipp Sudduth - Construction Worker
- Julio Monge - Construction Worker
- Kevin Daniels - Construction Worker
- Madeline Lee - Mama
- Janet Zarish - Saleslady
- Ken Prymus - Male Tourist
- Gammy Burdett - Female Tourist
- Teddy Coluca - Appalled Man
- Patti Karr - Appalled Woman
- Matte Osian - Unsympathetic Man
- Damon Standifer - Gino the Orderly
- William Christopher - Chaplain Olson
- Don McManus - Chris Tofsky
- Jessica Hendra - Postal Woman
- David Dean Bottrell - Animal Handler
- Steven Dean Davis - Member of Stomp
- Keith Middleton - Member of Stomp
- Bob Glouberman - Daniel Kaufman
- Bob Glouberman - Buchmans' Lawyer
- Reggie Lee - Gardner's Assistant
- Anthony Beninati - Masseur
- Trujo - Delivery Man
- Steve Park - Dr. Lee
- Kiah Gordon - Jane Santangello
- Tim Monsion - Auctioneer
- Tom Ayers - Guy With Cast
- Cynthia Lamontagne - Melissa Larson
- Miles Marsico - Zack Grundfest
- B.J. Ward - Dr. Cathy (voice)
- Judith Moreland - Mrs. Peterson
- Steven Ochoa - Cat Owner
- David L. Lander - Announcer
- Al Burke - Herb Miller
- Nils Allen Stewart - Six Fingers Malone
- Michael P. Byrne - Crowd Member
- Adam Biesk - Marianne's Date
- Julius Tennon - Officer
- Harry Hutchinson - Officer
- Betsy Monroe - Woman In Planetarium
- Lillian Hurst - Phyllis
- Brenda Hampton
- Helen Hunt
- Craig Knizek
- Maria Semple
- Stephen Engel
- Paul Reiser
Marita Geraghty hace el papel de Velma.
Willie Garson interpreta a Randall en la serie.
Helen Hunt interpreta a Jamie Buchman en la serie.
Paul Reiser interpreta a Paul Buchman en la serie.
Ellen DeGeneres interpreta a Nancy Bloom en la serie.
Brad Garrett hace el papel de The Nurse.
Kathy Griffin interpreta a Brenda en la serie.
Gates McFadden interpreta a Allison Rourke en la serie.
Alan Ruck interpreta a Lance Brockwell en la serie.
Alexandra Bokyun Chun hace el papel de Cassandra (Gift Wrapping Clerk).
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