- Charlie Finn - Spud (voice)
- Matt Hill - Kato Stewart (voice) (uncredited)
- Jason Marsden - Waiter (voice)
- Dante Basco - Jake Long (voice)
- Ashley Johnson - Gretchen Grundler (voice)
- Rickey D'Shon Collins - Vince LaSalle (voice)
- Keone Young - Jake's Grandpa (voice)
- Miranda Cosgrove - Sarah (voice)
- Miranda Cosgrove - Girl (voice)
- Miss Kitty - Trixie (voice)
- Kelly Slater - Himself (voice)
- John DiMaggio - Fu Dog (voice)
- John DiMaggio - Dr. Drakken (voice)
- Christy Carlson Romano - Kim Possible (voice)
- Will Friedle - Mackey Macaw Manager (voice)
- Will Friedle - Ron Stoppable (voice)
- Nicole Sullivan - Shego (voice)
- Archie Kao - (voice)
- Danny Mann - (voice)
- Elizabeth Daily - Blue Crayon (voice)
- Nancy Cartwright - Short Stuff: Experiment 297 (voice)
- Nancy Cartwright - Rufus (voice)
- Nancy Cartwright - Phantasmo: Experiment 375 (voice)
- Gigi Bermingham - (voice)
- Ving Rhames - Cobra Bubbles (voice)
- Amy Hill - Mrs. Hasagawa (voice)
- Amy Hill - (voice)
- Amy Hill - Hairdresser (voice)
- Kath Soucie - Trick or Treater (voice)
- Brenda Song - Mitzi Suzuki (voice)
- Brenda Song - (voice)
- Robbie Rist - (voice)
- Billy West - Angry Driver (voice)
- Maggie Wheeler - (voice)
- Nikita Hopkins - (voice)
- Glenn Shadix - 'Look At This' Producer (voice)
- 'Weird Al' Yankovic - Singing Minstrel (voice)
- Scott Thompson - Mrs. Pleakley (voice)
- Dave Foley - Priest (voice)
- Bruce McCulloch - Pixley Pleakley (voice)
- April Winchell - Mrs. Edmonds (voice)
- April Winchell - Aunt Sally (voice)
- April Winchell - Muriel Finster (voice)
- Mark McKinney - Bertley Pleakley (voice)
- Jess Winfield - (voice)
- Jess Winfield - Ship Captain (voice)
- Jim Cummings - Zach Mackillin / Rodeo Announcer (voice)
- Carlos Alazraqui - Ringmaster (voice)
- Clyde Kusatsu - Mr. Wong (voice)
- Clyde Kusatsu - (voice)
- Clyde Kusatsu - Mayor Kim (voice)
- Clyde Kusatsu - Bald Tourist / Luau Host (voice)
- Jennifer Hale - Tiffany (voice)
- Shaun Fleming - Keoni Jameson (voice)
- Tom Kenny - Policeman (voice)
- Zoe Caldwell - Grand Councilwoman (voice)
- Olivia DeLaurentis - (voice)
- Cree Summer - Lana (voice)
- Cree Summer - Show Judge (voice)
- Danica McKellar - (voice)
- Regis Philbin - Regis Philbin (voice)
- Frank Welker - Experiments (voice)
- Frank Welker - (voice)
- Frank Welker - Kixx (voice)
- Frank Welker - Poxy (voice)
- Frank Welker - Sparky / Yin / Yang / Slushy / Kixx (voice)
- Frank Welker - Mr. Stenchy: Experiment 254 (voice)
- Frank Welker - Tanlined Ice Cream Tourist (voice)
- Frank Welker - Sparky (voice)
- Frank Welker - Skip (voice)
- Derek Stephen Prince - Loki (voice)
- Tress MacNeille - (voice)
- Tress MacNeille - Bonnie: Experiment 149 (voice)
- Tress MacNeille - Richter / Cannonball (voice)
- Tress MacNeille - Bonnie / Felix-Oscar (voice)
- Tress MacNeille - Alien (voice)
- Tress MacNeille - Felix: Experiment 010 (voice)
- Lili Ishida - (voice)
- Lili Ishida - Yuki (voice)
- Bryan Cranston - Mr. Jamieson (voice)
- Tara Strong - Bebe Proud / Cece Proud / Puff (voice)
- Tara Strong - Babyfier (voice)
- Tara Strong - Adult Lilo (voice)
- Tara Strong - Angel (voice)
- Tara Strong - Angel: Experiment 624 (voice)
- Tara Strong - (voice)
- Dee Bradley Baker - (voice)
- Dee Bradley Baker - Mewrin (voice)
- Dee Bradley Baker - David Kawena (voice)
- kittie KaBoom - Trixie (voice)
- Rob Paulsen - Experiment 625 (voice)
- Rob Paulsen - (voice)
- Rob Paulsen - Experiment 625 / Experiment Computer (voice)
- Rob Paulsen - Reuben (voice)
- Rob Paulsen - Houdini (voice)
- Rob Paulsen - Experiment 625 / Gantu's Computer (voice)
- Rob Paulsen - Experiment 625 / Old Man (voice)
- Kali Whitehurst - (voice)
- Kali Whitehurst - Teresa (voice)
- Tommy Davidson - Oscar Proud (voice)
- Jeff Bennett - (voice)
- Jeff Bennett - Dr. Jacques Von Hämsterviel (voice)
- Jeff Bennett - Dr. Jacques Von Hämsterviel / Experiments (voice)
- Jeff Bennett - 627 / Dr. Jacques Von Hämsterviel (voice)
- Jeff Bennett - Clyde (voice)
- Jeff Bennett - Dr. Jacques Von Hämsterviel / Fibber (voice)
- Jeff Bennett - Experiments (voice)
- Tahj Mowry - Wade Load (voice)
- Pamela Adlon - Spinelli (voice)
- Matt Corboy - Various (voice)
- Matt Corboy - (voice)
- Haunani Minn - (voice)
- Paula Jai Parker - Trudy Parker-Proud (voice)
- Axel Alba - T.J. Detweiler (voice)
- Grey DeLisle - (voice)
- Grey DeLisle - Teenage Mertle (voice)
- Jo Marie Payton - Suga Mama Proud (voice)
- Zack Shada - Mikey Blumberg (voice)
- Jillian Henry - Elena (voice)
- Alyson Stoner - Victoria (voice)
- Kyla Pratt - Penny Proud (voice)
- Maurice LaMarche - Various (voice)
- Clancy Brown - EGO leader (voice)
- Aries Spears - Wizard Kelly (voice)
- Will Sasso - Heckler (voice)
- Bobcat Goldthwait - Nosy (voice)
- Rocky McMurray - Clyde (voice)
- Liliana Mumy - Mertle Edmonds (voice)
- Kunewa Mook - Moses Puloki (voice)
Nancy Cartwright hace el papel de Short Stuff: Experiment 297 (voice).
Clyde Kusatsu interpreta a (voice) en la serie.
Kelly Slater interpreta a Himself (voice) en la serie.
Daveigh Chase interpreta a Lilo Pelekai (voice) en la serie.
David Ogden Stiers interpreta a Dr. Jumba Jookiba (voice) en la serie.
Kevin McDonald hace el papel de Pleakley (voice).
Tia Carrere interpreta a Nani Pelekai (voice) en la serie.
Kevin Michael Richardson interpreta a Captain Gantu (voice) en la serie.
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