- Neal Brennan - Self - Panelist
- Theo Von - Self - Panelist
- Amy Schumer - Self
- Steve Byrne - Self - Panelist
- Kaley Cuoco - Self - Panelist
- Al Madrigal - Self - Panelist
- Chelsea Peretti - Self - Panelist
- Tina Fey - Self
- Chris Harrison - Self
- Nick Kroll - Self - Panelist
- Danny Trejo - Self
- Chelsea Davison - Self - Panelist
- Dennis Miller - Self - Panelist
- Jo Koy - Self - Panelist
- Punkie Johnson - Self - Panelist
- Robin Thede - Self - Panelist
- Stassi Schroeder - Self
- Bill Hader - Self - Panelist
- Henry Winkler - Self - Panelist
- D'Arcy Carden - Self - Panelist
- Stephen Root - Self - Panelist
- Dave Attell - Self - Panelist
- Isla Fisher - Self - Panelist
- Carrot Top - Self
- Bert Kreischer - Self - Panelist
- Todd Barry - Self - Panelist
- Justin Theroux - Self - Interviewee
- Arturo Castro - Self - Panelist
- Wayne Brady - Self - Panelist
- Lauren Lapkus - Self - Panelist
- Pete Holmes - Self - Panelist
- Stephen Rannazzisi - Self - Panelist
- Kyle Dunnigan - Self - Panelist
- Margaret Cho - Self - Panelist
- Rob Schneider - The Richmeister
- Rob Schneider - Self - Panelist
- Anthony Jeselnik - Self - Panelist
- J.B. Smoove - Self - Panelist
- Judd Apatow - Self - Panelist
- Chance the Rapper - Self - Panelist
- Bhad Bhabie - Self - Panelist
- Donnell Rawlings - Self - Panelist
- Jay Leno - Self - Panelist
- Natasha Leggero - Self - Panelist
- Norm Macdonald - Self - Panelist
- Kurt Busch - Self
- Mary Lynn Rajskub - Self - Panelist
- Colin Quinn - Self
- Bill Burr - Self - Panelist
- Jim Jefferies - Self - Panelist
- Brian Simpson - Self - Stand up
- Bobby Lee - Self
- Jim Gaffigan - Self - Panelist
- Fred Armisen - Self - Panelist
- Sean Penn - Self
- Nikki Glaser - Self - Panelist
- Drew Carey - Self - Panelist
- Maria Bamford - Self - Panelist
- Erik Griffin - Self - Panelist
- Joel McHale - Self - Panelist
- Michael Rapaport - Self - Panelist
- Dulcé Sloan - Self - Panelist
- Bill Engvall - Self - Panelist
- Ian Edwards - Self - Panelist
- Annie Lederman - Self - Panelist
- Dana Carvey - Self - Panelist
- Dana Carvey - Cocaine Expert
- Matt Walsh - Self - Panelist
- Erin Foster - Self - Panelist
- Sara Foster - Self - Panelist
- Tony Rock - Self - Panelist
- Patton Oswalt - Self - Panelist
- Lauren Sivan - Self - Panelist
- Brett Gelman - Self - Panelist
- Brett Gelman - Self
- Maya Rudolph - Self - Panelist
- Martin Short - Self - Panelist
- Deon Cole - Self - Panelist
- Todd Glass - Self - Panelist
- Cristela Alonzo - Self - Panelist
- Liz Carey - Self
- Rob Corddry - Self - Panelist
- Chris Franjola - Self - Panelist
- Megan Gailey - Self - Panelist
- Chris Irvine - Self - Panelist
- Tim Dillon - Self - Panelist
- Tim Dillon - Self
- Leighton Meester - Self - Panelist
- Taran Killam - Self - Panelist
- Brad Garrett - Self - Panelist
- Ron Funches - Self - Panelist
- Adam Devine - Self - Panelist
- Alexandra Shipp - Self - Panelist
- Eleanor Kerrigan - Self - Panelist
- Brad Williams - Self - Panelist
- Adam Ray - Self - Panelist
- deadmau5 - Self
- Bella Thorne - Self - Panelist
- Moshe Kasher - Self - Panelist
- Heather Dubrow - Self
- Thomas Lennon - Self - Panelist
- Diplo - Self - Panelist
- Vanessa Bayer - Self - Panelist
- Guy Branum - Self - Panelist
- Dusty Slay - Self - Panelist
- Sarah Tiana - Self - Panelist
- Louie Anderson - Self - Panelist
- Joey Diaz - Self - Panelist
- Christina Pazsitzky - Self - Panelist
- Jon Lovitz - Self
- Jon Lovitz - Self - Panelist
- Whitney Cummings - Self - Panelist
- Whitney Cummings - Self
- Benji Aflalo - Self - Panelist
- Charlotte McKinney - Self
- Liza Treyger - Self - Panelist
- Kevin Nealon - Self - Panelist
- Dean Delray - Self - Panelist
- Tony Hale - Self - Panelist
- Fortune Feimster - Self - Panelist
- Celeste Barber - Self - Panelist
- Jason Sklar - Self - Panelist
- Randy Sklar - Self - Panelist
- Amanda Cerny - Self - Panelist
- Brendan Schaub - Self - Panelist
- Jen Kirkman - Self - Panelist
- Jessica Kirson - Self - Panelist
- Greg Fitzsimmons - Self - Panelist
- Josh Wolf - Self - Panelist
- Liz Plonka
- David Spade
- Chelsea Davison
- Tom Brunelle
- Brad Wollack
- Frank Sebastiano
- Diego Felipe
Martin Short interpreta a Self - Panelist en la serie.
Brad Garrett hace el papel de Self - Panelist.
David Spade hace el papel de Self - Host.
Thomas Lennon hace el papel de Self - Panelist.
Michael Rapaport interpreta a Self - Panelist en la serie.
Sean Penn hace el papel de Self.
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