- Frankie Ryan Manriquez - Frankie Tenucci
- Frank Stallone Jr. - Nicky Deuce
- David Proval - Anonymous Author
- David Duchovny - Johnny Volcano
- Martin Mull - Lenord
- Joseph Gian - Joey Knuckles
- Teri Garr - Mrs. Abigail Portinbody
- Robin Williams - Kevin Powalski
- Tom Hanks - Tom Hanks
- Carl Reiner - Mr. Portinbody
- Ed Quinn - Rock Benson
- Dick Smothers - Dick Smothers
- Jonathan Winters - Q.T. Marlens
- Kevin Pollak - Sidney Portinbody
- Kelvin Yu - Man
- Tom Virtue - Dr. 'Mr.' Casey
- Tom Smothers - Tom Smothers
- Rip Taylor - Rappin' Rip
- Ruta Lee - Mrs. Ruta Blanchette
- Pat Crawford Brown - Candy
- Cristine Rose - Shelly
- Beth Littleford - Dr. 'Mrs.' Casey
- Erik Passoja - Gentleman
- Toni Ann Rossi - Woman
- Valerio Castellano - Valerio Castellano
- Stephon Fuller - Billy
- Mark Gagliardi - Giovanni
- Sergei Davidoff - Vlad
- Tanya Boyd - Renee
- Bridget Sienna - Maria
- Dyllan Christopher - Jeffrey
- Don Lake - Dr. Bill McClaw
- Don Lake - Micky Travisi
- Don Lake - Clown
- Mike Hagerty - Bill
- Mike Hagerty - Captain Lenderfak
- Sally Insul - Tony's Mom
- Gary Bayer - Gary
- Gary Bayer - Disheveled Man
- Eben Ham - Man
- Edmond Alan Forsyth - Ed
- Matt Adler - Rod
- Matt Adler - Garrett
- Joseph Will - Floyd
- Grant Heslov - Todd
- Sam Denoff - Father Farrell
- Channing Chase - Kathleen
- Steven Shaw - Richard
- Jack LaLanne - Jack LaLanne
- Mitchell Edmonds - Father O'Malley
- Michael Pasternak - The Rabbi
- Phyllis Diller - Phyllis Frost
- David Bowe - Bruce Chevillat
- McNally Sagal - Vicky
- Sam Pancake - Juggler
- Sam Pancake - Chance
- Sam Pancake - Constance
- Nick Cornish - Jeff Wisnefski
- Morgan York - Christine
- Jonathan Kimmel - Xavier
- Maz Jobrani - Paramedic
- Maz Jobrani - Maz
- Iqbal Theba - Iqbal
- Iqbal Theba - Deepak
- Garcelle Beauvais - Dr. Gamz
- Kathryn Joosten - Phyllis
- Dax Shepard - Kyle Levine
- Dax Shepard - Dr. Iskarr
- Ray Laska - Bill
- Bryan Greenberg - Timmy
- Victoria Gabrielle Platt - Choir Singer
- Ron Jason - Amazing Bottle Dancer
- John O'Leary - Older gentleman
- Johnny Holiday - Old weightlifter
- Anne Johnson - Rock diva
- Bryna Weiss - Pregnant lady
- Dick Van Patten - Self
- Bonnie Hunt
Bonnie Hunt interpreta a Bonnie Malloy en la serie.
Tom Hanks interpreta a Tom Hanks en la serie.
Carl Reiner hace el papel de Mr. Portinbody.
Robin Williams interpreta a Kevin Powalski en la serie.
Maz Jobrani hace el papel de Paramedic.
David Proval hace el papel de Anonymous Author.
Mark Derwin hace el papel de Mark Malloy.
David Alan Grier interpreta a David Bellows en la serie.
Charlie Stewart interpreta a Charlie Malloy en la serie.
Holly Wortell interpreta a Holly en la serie.
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