- Greg D'Agostino - Detective
- John D'Leo - Robbie Reeves
- Carrie Getman - Dora Keen
- Phyllis Somerville - Mrs. Raimes
- Mike Starr - Nelson
- Austin Basis - Willy Kramer
- Ramsey Faragallah - Raimes' Lawyer
- Seamus Davey-Fitzpatrick - Young Colin
- Francisco Burgos - Boy #1
- Sylvia Miles - Mrs. Salvaggio
- Pablo Schreiber - Kim Trent
- Bruce Kirkpatrick - Freddy Gerald
- Patrick Noonan - Dax Benson
- Susan Misner - Carol Ann Reeves
- Timothy Adams - John Philip Fisher
- Brian Avers - Sticker
- André De Shields - Bartender
- Arnie Burton - Lawrence Jones
- Nimo Gandhi - The Maharishi
- Marc Scrivo - Hippie #1
- Robin Lord Taylor - Jimmy
- Matthew Backer - Hippie Guy
- Ken Marks - Newscaster
- Ken Marks - Scientist
- Michael Mulheren - Patrolman
- Michael Mulheren - Sergeant
- Robert Klein - Elliott Casso
- Lenny Venito - Nick Profaci
- Don Puglisi - Jim Croce
- Dan Griffin - Druggie
- Chris Bauer - Father Tim
- Edi Gathegi - Fletcher Bellow
- Clarke Peters - Captain Bellow
- Chad L. Coleman - Suede
- Renée Elise Goldsberry - Denise Watkins
- Jesse Perez - Angel Ramirez
- Shirley Rumierk - Marta
- Babs Olusanmokun - Perp #2
- Brad William Henke - Michael H., the Hostage Taker
- Bill Irwin - Dr. Schwahn
- Carmen Goodine - Erica
- Stephen James King - Johnny H.
- Brian McCormack - Unit Commander
- Marcella Lowery - Nurse
- Elizabeth Hubbard - Sam's Soap Opera Mother
- Lee Tergesen - Lee Crocker
- Teddy Coluca - Uncle Butchie
- Alex Cranmer - Karl Kreshpane
- Tricia Paoluccio - Janice Kreshpane
- Douglas Schneider - Vic Tyler's minion
- Michael Aronov - Yuri Demidov
- Vincent Curatola - Anthony Nunzio
- Olek Krupa - Vasilli Lukin
- Joseph Badalucco Jr. - Carbone
- Daniel Yelsky - Lexi Voronin
- Yelena Shmulenson - Lexi's Mother
- Jeff Wiens - Ruben Penzler
- Bernardo Hernández - James
- Eric Balfour - Eddie Carling
- Kevin Conway - Donovan Stamp
- John Bedford Lloyd - Interrogator
- Joel Marsh Garland - Seven Fifty
- Joseph McKenna - Disfigured Man
- Guy Paul - Willis Ashton
- Antonia Rey - Latina Woman
- Bridget Berger - Biker Chick
- Matthew Cowles - Cowboy Dan
- Lee Cunningham - Biker Chick
- Cheyenne Jackson - Sebastian Grace
- Wallace Shawn - The Sorcerer
- Robert Clohessy - Frank Wyatt
- Kristen Connolly - Donna
- Del Pentecost - Carl Stefanski
- Natalie Gal - Lauren
- Natalie Gal - Doll
- Alexandra Daddario - Emily 'Rocket Girl' Wyatt
- Mark Greenberg - Tarantula
- Manoel Felciano - Bradley Thomas
- Duke Valenti - Grizzly
- Jessalyn Wanlim - Sweet Jane
- Kevin Henderson - Uniformed NJ Cop
- Isabelle Chester - Lulu
- Jennifer Ferrin - Ruth Tyler
- Jennifer Ferrin - Rose Tyler
- Laura Benanti - Denise Carling
- Jason Kravits - Jerry
- Armand Schultz - Councilman Prince
- Corey Stoll - Russell / Detective Ventura
- Emerald-Angel Young - Keisha
- Emerald-Angel Young - Lullaby Girl
- Quisha Saunders - Misty / Elena
- Eric Chan - Chinese Delivery Man
- Annie Meisels - The Bride
- Hector Lincoln - The Pimp
- Steven Marcus - Wino
- Steven Marcus - Homeless Man / Wino
- Malachy McCourt - The Wizard
- Laura Esterman - Sue Moyer
- Dominick Mancino - Detective
- Rene Lovit - Actress
- Kerry Bishé - Eve Flannery
- Chris Bowers - Tony Crane
- Fred Thompson - Chief Harry Woolf
- Peter Appel - Demetri Pantos
- Geoffrey Cantor - Ed Redlich
- Danai Gurira - Angela
- Thomas M. Hammond - Reporter #2
- Michael J. Burg - Truman Capote
- Kevin Kilner - Dr. Richard Olsen
- Janel Moloney - Pat Olsen
- Arthur J. Nascarella - Rooney
- Austin Pendleton - Dr. Goldman
- Brendan Sexton III - Danny Krasner
- Mary Testa - Phyllis
- Christopher Backus - Rodney Slaven
- Michael Cullen - Fire Chief GIbney
- John Cenatiempo - Sizable Ted
- Anslem Richardson - Sergeant Hoyte
- Billy Devlin - Bomb Squad Guy
- Carleigh Chirico - Laura Olsen
- Mark Deklin - Ronald Harris
- Gina Gershon - Rita
- Kelli Giddish - Carol
- Mark Linn-Baker - Lincoln Hart
- Keri Lynn Pratt - Leslie
- Marla Sucharetza - Mrs. Collins
- Hamilton Clancy - Derelict
- Scott Robertson - Doorman
- Tomasz Smolarski - Bartender
- Paige Turco - Colleen McManus
- Daniel Stewart Sherman - Big Patrick
- Bill Cwikowski - Timothy
- Rick Kain - Officer Kane
- Scott Adsit - Dr. Clifford Dorsett
- Peter Greene - Jimmy McManus
- Robert Creighton - Little Patrick
- Robert Berlin - Irish Gangster
- Robert Berlin - Kenny - Irish Mobster
- Baylen Thomas - Doctor
- Deidre Goodwin - Nurse
- Steve Rizzo - Detective Rizzo
- Liza Binkley - Intern
- Joe Toronto - Officer Priore
- Paul Damien Dios - Male Nurse
- Peter Quentin Smith - Paramedic
- Scott Shaw - Jason Mack
- Tanya Fischer - Windy
- Dean Winters - Vic Tyler
- Peter Gerety - Agent Frank Morgan
- Nick Damici - Bumper
- Waltrudis Buck - Old Annie
- Benjamín Benítez - Dominic Rivera
- René Ifrah - The Groom
Brendan Sexton III interpreta a Danny Krasner en la serie.
Chris Bauer interpreta a Father Tim en la serie.
Lisa Bonet interpreta a Detective Maya Daniels en la serie.
Del Pentecost interpreta a Carl Stefanski en la serie.
Peter Gerety interpreta a Agent Frank Morgan en la serie.
Robert Clohessy interpreta a Frank Wyatt en la serie.
Peter Appel interpreta a Demetri Pantos en la serie.
Jason O'Mara hace el papel de Det. Sam Tyler.
Harvey Keitel hace el papel de Lt. Gene Hunt.
Gretchen Mol interpreta a Policewoman Annie Norris en la serie.
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