- Martin Short - Sebastian Ballentine / Henry Palaver
- John Ashton - Alan Fewkes
- Adam Baldwin - Steven Harris
- Alexander Gould - Jack Trembley
- Ronny Cox - Dr. Douglas McManus
- Cybill Shepherd - Jolene Castille
- Missi Pyle - Trudy Malko
- Brad Garrett - Gary Munson
- Mark Boone Junior - Roger Pierson
- Chloë Sevigny - Christine Hartwell
- Norman Reedus - Derek Lord
- Joe Grifasi - Hashi Horowitz
- Lily Rabe - Nikki West
- Stephen Tobolowsky - Edwin Adelson
- Jeannetta Arnette - Sandra Knowles
- Brian Tarantina - Bill Jensen
- Rob Campbell - Harold Moore
- Patrick Collins - Mr. Hallander
- Chuck Cooper - Mr. Tassler
- Clem Cheung - Doorman
- Jon Seda - Antonio Dawson
- Frederick Strother - Siburt (scenes deleted)
- Lea Thompson - Michelle Osborne
- Hakeem Kae-Kazim - Chuckwei Bothame
- Tom Skerritt - Oliver Taft
- Maria Bello - Vivian Arliss
- Beverly D'Angelo - Serafina Carisi
- Lili Taylor - Martha Thornhill
- Stacy Keach - Orion Bauer
- Brenda Blethyn - Linnie Malcolm
- Elliott Gould - Walter Tompkins
- Linus Roache - Michael Cutter
- Paul Calderon - Eric Molina
- Patricia Charbonneau - Paige Beddels
- Kathy Griffin - Babs Duffy
- Carl Weathers - SA Mark Jefferies
- Omar Benson Miller - Rudi Bixton
- Elpidia Carrillo - Maria Ramos
- Sharon Stone - Jo Marlowe
- Michael Shannon - Avery Shaw
- Bill Duke - Ed Pastrino
- Jerry Lewis - Andrew Munch
- Jeffrey Tambor - Lester Cohen
- Patricia Arquette - Jeannie Kerns
- Sandra Bernhard - Defense Attorney Priscilla Chaney
- Michael Rapaport - Richie Caskey
- Jake Weber - Robert "Bob" Flynn
- Alexis Dziena - Mia Van Wagner
- Bronson Pinchot - Henry Carlisle
- Cary Elwes - Sidney Truex
- Eugene Byrd - Carlos Medina
- Ben Gazzara - E.A.D.A.
- Michael Emerson - Allan Shaye
- Benito Martinez - Santino Rojas
- Pell James - Alicia Morley
- Brad Dourif - Dr. Iggy Drexel
- Whoopi Goldberg - Janette Grayson
- Christopher McDonald - Harold Coyle
- Ned Bellamy - Peter Carson
- Chris Bauer - Tom Cole
- Mariska Hargitay - Olivia Benson
- Amanda Plummer - Miranda Cole
- Richard Bright - Robert Sawyer
- Wayne Knight - Grigor
- Scott Bakula - Kent Webster
- Antone Pagán - Hot Dog Vendor
- Robin Williams - Merritt Rook
- Dianne Wiest - Interim D.A. Nora Lewin
- Kathy Baker - Hannah Curtis
- Rosanna Arquette - Alexa Pierson
- Marcia Gay Harden - Dana Lewis
- Mercedes Ruehl - Lucia Barba
- Susan Blommaert - Judge Rebecca Steinman
- Tom Guiry - Gavin Sipes
- Franky G - Jose Marquez
- Griffin Dunne - Benno Gilbert
- Glenn Plummer - Derek Thompson
- Tom Sizemore - Lewis Hodda
- John Doman - William Rand
- Saul Rubinek - Mr. Price
- David Mucci - Sergeant
- Connor Paolo - Zachary Connor
- Robert Sean Leonard - Kenneth O'Dwyer
- Wentworth Miller - Isaiah Holmes
- Josh Charles - Sean Kelley
- Steven Bauer - Raphael Gardner
- James Waterston - Mr. Harvey
- Joe Morton - Ray Bevins
- Karen Allen - Paula Varney
- Miriam Colon - Yolanda Gonzales
- George Martin - Father Abbot McCourt
- Catherine Bell - Naomi Cheales
- Diana Scarwid - Jackie Madden
- Brian Bloom - Gabriel Thomason
- Alfred Molina - Gabriel Duvall
- Robert Foxworth - Dr. Benjamin Hadley
- Mark Margolis - Rom-Baro
- Mary Steenburgen - Grace Rinato
- Steven Hinkle - Ryan Clifford
- Wyclef Jean - Vincent Love
- Michael Lerner - Defense Attorney Morton Berger
- Melora Walters - Laurel Linwood
- Lois Smith - Rebecca Tolliver
- Casey Siemaszko - EPA Official
- Elizabeth McGovern - Faith Sutton
- Robert Patrick - Ray Schenkel
- Joan Cusack - Pam Burton
- Saul Stein - Tom Nomaks
- Christine Ebersole - Hilary Regnier
- Treat Williams - Jake Stanton
- Connie Nielsen - Dani Beck
- Dallas Roberts - Greg Yates
- Burt Young - Eddy Mack
- Melinda Dillon - Jenny Rogers
- Spencer Treat Clark - Brian Coyle
- Leland Orser - Kevin James Walker
- Tommy Flanagan - Connor Murphy
- Fred Savage - Michael Gardner
- Pam Grier - Assistant US Attorney Claudia Williams
- Steve Park - Eugene Lee
- Brian Reddy - Ross St. Clair
- Bob Gunton - Lawrence Hendricks Sr.
- Wayne Duvall - Seth Milstead
- Vincent Laresca - Alex Muñoz
- Ray McKinnon - William Labott
- Mike Colter - Samuel Mbazzi
- Peter Gerety - Peter Harrison
- Margo Martindale - Rita Gabler
- Riki Lindhome - Irena Nowak
- Celia Weston - Margaret Talmadge
- Trey Wilson - Bruce
- David Patrick Kelly - Orville Underwood
- Rosie Perez - Eva Banks
- Olympia Dukakis - Debby Marsh
- Robert Clohessy - Interviewing Detective (uncredited)
- Jane Adams - Joanne Parsons
- Terry Serpico - Deacon Brinn
- Sara Gilbert - Caitlyn Ryan
- Debbon Ayer - Mrs. Douglas
- Jerry Orbach - Detective Lennie Briscoe
- David Pittu - Investment Banker
- Kelly Bishop - Registrar
- Stephen Collins - Pierson Bartlett
- Shannon Cochran - Cindy Cramer / Sarah
- Ashton Holmes - Davis Harrington
- Peter Appel - Marvin Friedman
- Don Creech - Atkins
- Michael Badalucco - Tom Galli
- Keir Dullea - Judge Walter Thornburg
- Charles Martin Smith - Sheriff Bartley
- Chris Elliott - Pete Matthews
- Octavio Pisano - Joe Velasco
- Kevin Kane - Terry Bruno
- Tom DiCillo
- Michael Pressman
- Robert E. Warren
- Oscar Rene Lozoya II
- Peter Werner
- Clark Johnson
- Mick Betancourt
- Allison Intrieri
- Marilyn Osborn
- Samantha Corbin-Miller
- David Graziano
- Gabriel Vallejo
- Anastasia Puglisi
- Peter Blauner
- Joe Lazarov
- Kristie Fitts
- Michael R. Perry
- Jonathan Strauss
- Benjamin Gieschen
- Bill Daly
- Libby Pedersen
- Melody Peng
- John Benson
- P. Patrick Hogan
Martin Short interpreta a Sebastian Ballentine / Henry Palaver en la serie.
John Ashton interpreta a Alan Fewkes en la serie.
Adam Baldwin interpreta a Steven Harris en la serie.
Alexander Gould interpreta a Jack Trembley en la serie.
Ronny Cox interpreta a Dr. Douglas McManus en la serie.
Cybill Shepherd hace el papel de Jolene Castille.
Missi Pyle interpreta a Trudy Malko en la serie.
Brad Garrett interpreta a Gary Munson en la serie.
Mark Boone Junior interpreta a Roger Pierson en la serie.
Chloë Sevigny interpreta a Christine Hartwell en la serie.
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