- Victor Argo - Mr. Garcia
- Lily Rabe - Siena Boatman
- Stephen Tobolowsky - Jim Halliwell
- Brian Tarantina - Johnny Di Rogga
- Rob Campbell - Daniel Heltman
- Christopher Lloyd - Carmine
- George DiCenzo - Judge Raoul Sabatelli
- Alicia Witt - Nola Falacci
- Ralph Macchio - Louis Marciano
- Paul Calderon - Marcus Feingold
- Patricia Charbonneau - Sydney Markham
- Trevor Morgan - Donny Carlson
- Jake Weber - Karl Atwood
- Bronson Pinchot - Dr. Greg Ross
- Frank Adonis - Eddie
- Michael Emerson - Gerry Rankin
- Tony Goldwyn - Frank Goren
- Whoopi Goldberg - Chesley Watkins
- Christopher McDonald - Evan Korman
- Chris Bauer - Murtaugh
- Matt Damon - Self (voice)
- Richard Bright - Frank Lowell
- Neal Jones - Chief of Detectives Bradshaw
- Antone Pagán - Eduardo Romero Mendez
- Dianne Wiest - Interim D.A. Nora Lewin
- Kathy Baker - Camille Hayes-Fitzgerald
- Rosanna Arquette - Kay Connelly
- Tom Guiry - Marcus Randolph
- Griffin Dunne - Henry Talbott
- John Doman - Roy Markham
- Cameron Bowen - Ralph Pittino
- Mary Elizabeth Mastrantonio - Zoe Callas
- James Waterston - Paul Walters
- S. Epatha Merkerson - Lieutenant Anita Van Buren
- F. Murray Abraham - Theodore Nichols
- George Martin - Harry Sternman
- Harris Yulin - Thomas M. Grady, Sr.
- Xander Berkeley - George Pagolis
- Michael P. Moran - Mr. De Santis
- Mark Margolis - Mario Damiano
- Michael Biehn - Leland Dockerty
- Chris Penn - Tommy Onerato
- Neal McDonough - Monsignor McTeal
- Lois Smith - Betty Bennett
- Casey Siemaszko - Harvey Gruenwald
- Jamey Sheridan - James Deakins
- Evan Parke - Goro
- Dallas Roberts - Abel Hazard
- Michael Murphy - Judge Peter Blakemore
- Tomas Arana - Rudy Langer
- Leland Orser - Dan Wyler
- Jeff Goldblum - Zach Nichols
- Steve Park - Dr. Shimo
- Del Pentecost - Forensics Technician
- J.R. Horne - Dryden
- Mary McCormack - Mary Shannon
- Wayne Duvall - Kurt Plumm
- Vincent Laresca - Antonio Morales
- Mike Colter - Dave Oldren
- Peter Gerety - George Hawkins
- Celia Weston - Joanne Dexler
- David Patrick Kelly - Bo Levy
- Alice Krige - Gillian Booth
- Yusuf Gatewood - Detective Lewis
- Curtiss Cook - Rob Robbins
- Robert Clohessy - Roger Lemoyne
- Jane Adams - Sylvia Campbell
- Terry Serpico - Leslie Roche
- Amir Ali Said - Sean Colt
- David Cross - Ronnie Chase
- Jerry Orbach - Detective Lennie Briscoe
- David Pittu - Roy Lofton
- Stephi Lineburg - Maggie Colter
- Ashton Holmes - Hank
- Peter Appel - Theodore 'Chubby' Viviano
- Don Creech - Colin Flynn
- John Scurti - Fred DeLuca
- Theresa Randle - Patricia Kent
- Warren Leight
- Walon Green
- Dick Wolf
- Peter Jankowski
- Chris Brancato
Victor Argo interpreta a Mr. Garcia en la serie.
Lily Rabe hace el papel de Siena Boatman.
Stephen Tobolowsky hace el papel de Jim Halliwell.
Brian Tarantina hace el papel de Johnny Di Rogga.
Rob Campbell hace el papel de Daniel Heltman.
Christopher Lloyd interpreta a Carmine en la serie.
George DiCenzo hace el papel de Judge Raoul Sabatelli.
Alicia Witt hace el papel de Nola Falacci.
Ralph Macchio hace el papel de Louis Marciano.
Paul Calderon hace el papel de Marcus Feingold.
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