- Brian Downey - Stanley H. Tweedle
- Brian Downey - Brud Parsnip
- Tom Gallant - The Lexx (voice)
- Tom Gallant - The Lexx
- Xenia Seeberg - Xev Bellringer
- Xenia Seeberg - Prince
- Eva Habermann - Zev Bellringer
- Eva Habermann - Zev Bellringer (archive footage)
- Jeffrey Hirschfield - 790 (voice)
- Jeffrey Hirschfield - Black Rook (voice)
- Jeffrey Hirschfield - Feemak
- Jeffrey Hirschfield - Dick Dongler
- Jeffrey Hirschfield - P.T. Bando
- Wayne Robson - Gubby Mok
- Rutger Hauer - Bog
- Ryan Cooley - Digby
- Benjamin Sadler - Nool
- Gerry Wolff - Snik
- Tim Curry - Poet Man
- Barry Bostwick - Thodin
- Malcolm McDowell - Yottskry
- Andy Jones - Smoor
- Doreen Jacobi - Wist
- Michael Habeck - Feppo
- Bill Carr - Correction Center Guard
- Jocelyn Cunningham - Cluster Major
- Richard Donat - Megashadow Admiral
- Marty Simon - Brain No. 14
- Janice Evens - Computer (voice)
- Barbara Kowa - Wig Girl
- Alan MacGillivray - Argon Protopi
- Andrei Mahankov - Rebel
- David Renton - Senior Cleric / Joshua
- Elizabeth Richardson - Holo Prosecutor
- Chris Rowntree - Holo Official
- Joseph Rutten - Slab Prisoner
- Robert Sigl - Petrif
- Holger Kunkel - Vigl
- Holger Kunkel - Boork
- Sanjay Talwar - Honar
- Horst Ulan - Cluster General
- Gary Vermeir - Scientist
- Kate Rose - Holo Woman
- Mike Petersen - Cluster Lizard / 790 Robot
- Mike Petersen - 790 Robot / Squish
- Rachel Grover - Zev's Mother
- Rainer Matsutani - Brunnen-G General
- Gil Brenton - Tem
- Jennifer Overton - Matron
- Jennifer Overton - Customs Officer
- Hussi Kutlucan - Orlluk
- Hans-Dieter Brückner - Grullek
- Shaun Clarke - Zev's Father
- Shaun Clarke - Reteep
- Arno Wyzniewski - Kuk
- Sherry Devanney - Kyyra
- Dieter Laser - Mantrid
- Nicolás Artajo - Child
- Nicolás Artajo - Kid
- Burgandy Code - Navigator
- Simon Licht - Dr. Kazan
- Oliver Stern - Dr. Funz
- Eva Ebner - Mrs. Deebee
- Errol Shaker - Administrator
- Ian T. Dickinson - Berg
- Jeremy Akerman - Transport Major
- Jeremy Akerman - Proo, bald Pimp Sister
- Tatjana Alexander - Nurse
- Roman Podhora - L.L. Boosh
- Sandra Keller - Yoyo / Nurse / Skooj
- Thorsten Feller - Liggum
- Gabi Fleming - Dead Female Body
- Lisa Hynes - Zev
- Lisa Hynes - Original Xev
- Oliver Stolz - Bodyguard
- Nina Franoszek - Grand Prosecutor Jihana
- Peter Scollin - Guard
- Harvey Friedman - Guard
- Lionel Doucette - Holo Judge
- Diego Chambers - Aulk
- Ellen-Ray Hennessy - Rissha
- Noah Dalton Danby - Varrtan
- Rick Collins - Fat Man
- Clive Sweeney - Priest
- Clive Sweeney - Megashadow Adjutant
- Dave Maddeaux - Customer
- Page Fletcher - Captain Jebbed
- C.J. Lusby - Nympho
- Maury Chaykin - Pa Gollean
- Chas Lawther - President Jeff Davison
- Chas Lawther - Video Customs Officer
- Amy Kerr - Desh
- Louise Wischermann - Lyekka
- Louise Wischermann - Twinsister Lyekka
- Louise Wischermann - Lulu
- Andrew Bigelow - Enox
- Andrew Bush - Tad
- Brandon McCarvell - Norb Gollean
- Brandon McCarvell - Norb
- Nikki Barnett - Kanana
- Matthew Burton - Brother Randor
- Christian Murray - Gold Lamé Man
- Christian Murray - 792
- Matthias Klimsa - Brother Treygor
- Martin Höner - Older Brother
- Milton Welsh - Rat II
- Mary Walsh - Heedia
- Stephen J.M. Sisk - Pilot
- Stephen J.M. Sisk - Flintokk, Head Pimp Sister
- David James Lewis - Fruitcake
- Lenore Zann - The Dark Lady
- Rolf Kanies - Reginald J. Priest
- Rolf Kanies - Priest
- Rolf Kanies - President Reginald J. Priest
- Andre Haines - Doily
- Andre Haines - Hunted
- Laura Mae Nason - Dream Girl
- Laura Mae Nason - Guard
- Kerry McPherson - Skye
- Stacy Smith - Calico
- Lori Heath - Hologram Guard
- Lex Gigeroff - Barnabas K. Huffington
- Lex Gigeroff - Nozzle (voice)
- Lex Gigeroff - Dr. Rainbow
- Lex Gigeroff - Bound Man
- Lorraine Segato - Time Prophet
- Dick Sircom - Judge
- Earl Pastko - Brizon
- Nigel Bennett - Prince
- Linda Busby - Chief Handler
- Ralph Brown - Duke
- David Albiston - Moth Breeder
- David Albiston - Mothbreeder
- Ellen Dubin - Giggerota
- Ellen Dubin - Genevieve G. Rota
- Ellen Dubin - Queen
- Ellen Dubin - Giggerota (archive footage)
- Ellen Dubin - Genevieve G. Rota / Pope Genevieve
- Janaya Stephens - Peach
- Robyn Palmer - Pear
- Roberta Angelica - Plum
- Janet Wright - First Lady Priest
- Janet Wright - Lorca
- Mika Ward - Cherry
- Mark A. Owen - Balloonist
- Mark A. Owen - Big Angry Ed
- Mark A. Owen - Hunter
- Craig Wood - Chief Guard
- Patricia Zentilli - Bunny Priest
- Patricia Zentilli - Bunny
- Patricia Zentilli - Laleen
- Patricia Zentilli - Young woman
- Sandra Leonhard - Tish
- John Dartt - Holo Lawyr
- John Dartt - Sheriff
- Jeff Pustil - Fifi
- Jeff Pustil - Schlemmi
- Jeff Pustil - Farley Kuckle
- Jeff Pustil - Fifi (archive footage)
- Urs Remond - Cab
- Hans Brückner - Zin
- Josh MacDonald - Sergeant
- Jamie Bradley - Jood
- Jamie Bradley - TV Technician
- Nicole Ciroth - Minx
- Udo Jolly - Dr. Bunz
- John Dunsworth - Lett
- John Dunsworth - Old Cracker / Voice of Pilot
- John Dunsworth - Divine Predecessor (voice) (uncredited)
- John Dunsworth - Guard
- John Dunsworth - Video Asteroid Commander
- John Dunsworth - White Rook (voice)
- John Dunsworth - Reporter
- John Dunsworth - Berf
- Julia Haacke - Lily
- Sabrina Rattey - Daisy
- Ina Paule Klink - Daffodil
- Jack Carr - Bellhop
- Jack Carr - Video Boy Cleric
- Sam White - Trout
- Sam White - Rexal
- Polly Jo Pleasence - Rivet
- Walter Borden - His Divine Shadow (voice)
- Walter Borden - Dr. Ernst W. Longbore
- Walter Borden - Dr. Ernst Longbore
- Walter Borden - The Wozzard
- Walter Borden - Dr. Longbore
- Sherry White - Middle Aged Woman
- Sherry White - Nympho
- Diane Langton - Hammer
- Jelena Budimir - Socket
- Jimmy Somerville - Satin
- Wanja Mues - Pearl
- Craig Charles - The Warden
- Hattie Hayridge - Sub-Warden Heidi
- Geoff Herod - Brock
- Geoff Herod - Missionary Man
- Glenn Wadman - Archaeologist
- Glenn Wadman - Officer
- Glenn Wadman - Prisoner
- Glenn Wadman - Tour Guide
- Howard Attfield - Executive
- Alexis Conran - Mustafa Al Hambra
- David Francis - Newfie
- David McClelland - Guard
- John Pearson - Cobra
- Andy Gätjen - Ridolan
- Andy Smith - Eco Tourist
- Jim Swansburg - Cmdr. Bricklin
- Kevin Curran - Dougall
- Tara Doyle - Tina
- Jim Fowler - Rooster
- Bill Jessome - Chief Justice
- Chris Owens - Biff
- Stephen Morgan - Chip
- Anna Cameron - The Time Prophet
- Anna Cameron - Older Vlad
- Anna Cameron - Black Bishop
- Michael Pellerin - Road Worker
- Michael Pellerin - Wern
- David Charles - Boy
- Travis Ferris - Guard
- Peter James - Guard
- Lydia Klenck - Shower Nude
- Brian Carter - Organ Grinder
- Brian Carter - Cyborg / 791
- Jay Benedict - Vet
- Lee J. Campbell - Journalist
- Karen Beverly - Journalist
- Stephen McHattie - Moss
- Stephen McHattie - E.J. Moss, Commander of Eagle 5
- Stephen McHattie - Field Commander Moss
- Louis Del Grande - Roada
- Louis Del Grande - Louie
- Maggie Holland - Elderly Lady
- Alec Linstead - Cardinal Meinpo Duftet
- Rhonda McLean - Mom
- Bruce Murphy - Junior
- Peter Blake - Oliver
- Rejean Cournoyer - Earl
- Nunzio Lombardo - Valentino
- Ross O'Hennessy - Cedric
- Justin Pierre - Bob
- Silvio Simac - Hank
- Landy Cannon - Sergeant Dwayne Eagle
- Landy Cannon - Root
- Georgia Zaris - Farley's Assistant
- Lois Brown - Older Woman
- Mike Daly - ATF Agent
- Philip Dinn - Local
- Stephen Coats - The Cloak
- Stephen Coats - Dad
- Martha Irving - Doris
- Frank Kelly - Father Pickle
- Bette MacDonald - Marge
- Heather Rankin - Phoebe
- Maisie Rillie - Sharon
- Andrea Green - Davinia Silver
- Peter Guinness - Joseph Van Helsing
- Angie Hill - Muffy
- Lionel Jeffries - Father Borscht
- Keith-Lee Castle - Renfield
- Gary Levert - Bereaved Dad
- Gary Levert - Sonny 'King' Tutti
- Gary Levert - Lead Balloonist
- Arthur Spray - Gypsy Servant
- John Standing - Count Dracul
- Tony Anholt - Anchorman Bob
- Tony Anholt - Anchorman
- Tom Haney - Studio Guard
- Robert Maillet - Leroy
- Gareth Miller - Lieutenant
- Graham Pountney - Professor Erasmus Ponts
- Graham Pountney - Commentator
- David Verrey - Businessman
- Gordon Patrick White - Thief
- Alun Lewis - Uther de Glastonbury, formerly known as Nigel Bumsen
- Jeremy Peters - Surgeon
- Richard Braine - Card Carrying Druid
- David Christoffel - Cellphone Druid
- Nick Ewans - Colin
- Tim Frances - Puck
- Patrick Gordon - Oberon
- Melanie Harris - Marjorie
- Mick Walter - Titania
- Geoff McBride - Mothbreeder / 769
- Geoff McBride - Moth Breeder
- Cindy Sampson - Druid Girl
- Clive Merrison - Professor Shnoog
- Minna Aaltonen - Vlad
- Minna Aaltonen - White Bishop
- Joshua Young - Moth Breeder
- Agumeuay Nakanakis - Native American Leader
- Stan Carew - French Diplomat
- Britt Ekland - Dulcibella Sternflanks
- John Diamond - Burl
- Rupert Evans - Cleasby
- Dan Fredenburgh - Gordon
- Marem Hassler - Skankita
- Ryan McCluskey - Tad
- Laura Patch - Piccalina
- Marguerite McNeil - Stress Counselor
- Matt Zimmerman - Supervisor
- Celia Henebury - Didi Figgleshrick
- Rory MacGregor - Mort the Mortician
- Mary Alvena Poole - Older Wife
- Stephanie Redding - Twin Daughter
- Richard Hanson - Devlin
- Finlay Robertson - Ryan
- Dennis Envoldsen - Corporal Harrison Birdie
- Glen Michael Grant - Private First Class Roland Bogie
- Michael J. Reynolds - Colonel Donald K. Gore
- Seán Cullen - Remo
- Kelsa Kinsly - Slave Girl 88
- Heidi von Palleske - Slave Girl 24
- John Lebar - The Mummy - Draco
- Jeremiah Sparks - Cabbie
- Mason Phillips - Wyatt
- Togo Igawa - Monk
- Doug Barron - Secretary of Defense
- Sam Douglas - General Klebstock
- Nancy Marshall - Geekette
- John Gleeson - Doctor
- Peter Baylis - Balloonist
- Stephan Wagner
- Srinivas Krishna
- Paul Donovan
- Carl Harvey
- David McLeod
- William Fleming
- Jon Spira
- Lex Gigeroff
- Andrew Selzer
- Jeffrey Hirschfield
- Tom de Ville
- Paul Green
- Marty Simon
Rutger Hauer interpreta a Bog en la serie.
Michael Habeck interpreta a Feppo en la serie.
Milton Welsh interpreta a Rat II en la serie.
Stephen McHattie interpreta a Field Commander Moss en la serie.
David James Lewis interpreta a Fruitcake en la serie.
Brian Downey hace el papel de Stanley H. Tweedle.
Xenia Seeberg hace el papel de Xev Bellringer.
Michael McManus hace el papel de Kai.
Tom Gallant interpreta a The Lexx (voice) en la serie.
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