- Hamish Linklater - Clark Debussy
- Lauren Tsai - Jia-Yi / Switch
- Navid Negahban - Amahl Farouk / Shadow King
- Luke Roessler - David Haller (6-8 Years)
- Luke Roessler - David
- Ellie Araiza - Philly
- Lillian Lim - The Monk
- Jason Mantzoukas - Jerome / Wolf
- Stephanie Corneliussen - Gabrielle
- Harry Lloyd - Charles Xavier / Professor X
- Margaux Brooke - Eloise
- Matt Hamilton - Ben
- Mike Azevedo - 'Renal Failure' Alvarez
- Ese Atawo - Day Room Duty Nurse
- June B. Wilde - Science Teacher
- Maddie Phillips - Jr. Prom Date (Crying)
- Stephanie Lavigne - Patient Dancer #7
- Camille Mitchell - Dr. Bates
- Eddie Jemison - The Greek
- Daniel Kailin - Asian Teenager
- Scott Lawrence - Dr. Poole
- Kirby Morrow - Benny
- Kirby Morrow - Large Man Karl
- Jillian Dion - Irma Whitecloud
- David Selby - Brubaker
- David Ferry - Dr. Kissinger
- Gabriel Jacob-Cross - Ptonomy (5 yrs)
- Paul Belsito - The Man Who Hides
- Stephanie Van Dyck - Skeletal Fat Lady
- Sharlene Royer - Ptonomy's Mom
- Jemaine Clement - Oliver Bird
- Keir O'Donnell - Daniel
- Brad Mann - Rudy
- Quinton Boisclair - Devil with the Yellow Eyes
- Sebastian Billingsley-Rodriguez - David (Toddler)
- Tatyana Forrest - David's Mother
- Dario Giordani - David's Father
- Paul Jarrett - General Stanley
- Jennifer Kitchen - Burt Hart
- Devyn Dalton - Angry Boy
- Christopher Collins - Wall Street Frat Boy
- Nathan Blair - 10 Year Old Boy
- Christian Convery - David (4 Years Old)
- Molly Hagan - Laura Mercer
- Seamus Dever - Don Eichman
- Valentina Izumi - David's wife
- Lily Rabe - Joan Barrett
- Pearl Amanda Dickson - Teen Syd
- Violet Hicks - Young Syd
- Carmela Nozza Guizzo - Young Amy (4 yrs)
- Lola Raie - Singing Girl #3
- Lexa Gluck - Vermillion #3
- Alan Fine
- Lauren Shuler Donner
- Noah Hawley
- Jim Chory
- Simon Kinberg
- Jeph Loeb
Lily Rabe hace el papel de Joan Barrett.
Eddie Jemison interpreta a The Greek en la serie.
Dan Stevens hace el papel de David Haller / Legion.
Rachel Keller hace el papel de Sydney ‘Syd’ Barrett.
Aubrey Plaza hace el papel de Lenny Busker.
Jeremie Harris interpreta a Ptonomy Wallace en la serie.
Amber Midthunder interpreta a Kerry Loudermilk en la serie.
Bill Irwin interpreta a Cary Loudermilk en la serie.
Hamish Linklater hace el papel de Clark Debussy.
Lauren Tsai interpreta a Jia-Yi / Switch en la serie.
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