- Lorenzo James Henrie - Cody
- Kevin Dunn - Vic Tilden
- Lois Smith - Rose Sinclair
- Bill Macy - Martin
- Sam Doumit - Rachel Fischer
- Chad Todhunter - Mystery Man
- Ron Fassler - Coach
- James Gammon - Bill Barkley
- Leonard L. Thomas - Security Guard
- Charisma Carpenter - Julie Random
- Michael Murphy - Emmet
- Paul Butcher - Spencer DeWitt
- Vondie Curtis-Hall - Dele Ekoku
- Brooke Marie Bridges - Sofia DeSouza
- Dean Norris - Danny
- Jeff McCracken - Gavin
- Carlos Gómez - Agent Valdez
- Dameon Clarke - Jim, Bomb Squad Member
- Marc Casabani - Alim
- Tony Hawk - Tony Hawk
- Sharon Leal - Monique DeSouza
- Brian Baumgartner - Wes
- Warren Davis - Middle Aged Man (uncredited)
- David Clennon - Ralph Gravis
- Octavia Spencer - Flight Attendant
- Beverly Leech - Captain Rachel Tyler
- Loren Lester - Immigration Attorney
- Joey Slotnick - Warren
- Valerie Cruz - Carla
- Jason Gedrick - Gavin
- Nicki Aycox - Christine
- Nestor Serrano - Mayor Hortense
- Sasha Barrese - Caitlin Mansfield
- Beth Dover - Missy
- Rusty Schwimmer - Pam
- Erika Alexander - Allison
- Eric Lange - Doctor
- Kirsten Vangsness - Ticket Agent
- Leyna Nguyen - On-Air Reporter
- Gail Cronauer - Serb Woman
- Iona Morris - Selma Dominic
- Geoff Meed - Justin Bryant / Santa
- Johnny Galecki - Leland Pressman
- Nicholas Shaffer - Cashier
- Brian Appel - Basil
- Sarah Buehler - Teenager
- Joel David Moore - Eddie Carson
- Bill Smitrovich - Nick's Supervisor
- Dylan Neal - Harley's Date
- Gocha Chertkoev - Yuri, Serb Navigator
- Robyn Cohen - Marla
- Irene Cortez - Marivi
- Edward Rudolph Flores - Dan the Father
- Bob Hess - Bomb Squad Captain
- Lee Irving - Mayor's Assistant
- Britanni Johnson - Wife
- Chane't Johnson - Tanika
- Oryan Landa - International Traveler
- Elizabeth Lee Mei-Fung - Ticket Agent
- Stephen Liska - Serb Pilot
- John C. McDonnell - Phil, TSA Supervisor
- Liz Mikel - Angry Woman
- Rick Morrow - Frank
- Ethan Rains - Joe
- Dominic Rains - Cyrus
- Manuel Velazquez - Governor's Agent
- Jack Watkins - Air Traffic Controller
- Richard Phillips - FAA Agent
- Steve Reevis - Hawk Man
- Juan Garcia - FBI Agent Atwill
- William Stanford Davis - Engineer Dietrich
- Susan Han - EMT
- Irene Roseen - Martha
- Myrna Niles - Sadie
- Sydney Shapiro - Oceanic Attendant
- Will Greenberg - Cashier
- Lorena Mena - LAX Attendant
- David Lewison - Mike
- Steve Heller - Fred
- Ryan Honey - Co-pilot Fletcher
- Bill Jacobson - Air Marshall
- Sharon Brathwaite-Sanders - Classmate Jill
- Vincent Jerman-Jerosa - Classmate Artie
- Nancy Linari - Flight Attendant Gayle
- Dato Bakhtadze - Foreign Passenger
- Nikki Braendlin - Female Passenger
- Gerald Emerick - John Sinclair
- James Sharpe - TSA Agent Quentin Reynolds
- Irina Stemer - Foreign Passenger's Wife
- Johnny Venokur - Suspect
- Yareli Arizmendi - Amanni
- Rob Brownstein - Almim's Lawyer
- Larkin Campbell - Dewey
- Challen Cates - Amani's Lawyer
- Len Cordova - Chris
- Conor Duffy - Passenger
- Amir Faraj - Jaleel
- Jeffrey Scott Kelly - Man
- Randy Kovitz - State Dept. Rep.
- Craig Robinson - Wayne
- John Ross - Marshall
- Russell Towery - TSA Agent
- Jessica Whitney Gould - Hilary
- Alexandra Bokyun Chun - Kim
- Keith Diamond - FBI Agent Lewis
- Jenna Gering - Danielle
- Zvonimir Hace - Pilot
- Patricia Heller - Angry Woman
- Brian Jacobs - Photo Phil
- Peter O'Meara - Paparazzi Craig
- Michael O'Neill - Alonso Mathews
- Angela Russo-Otstot - Lily
- Jonathan Sadowski - Oleg Karponov
- Jill Small - Lizzie
- Abigail Marlowe - Flight Attendant Petra
- Abigail Marlowe - Melissa
- Josh Green - Red Shoe Streaker
- Paul Keeley - Head of Airport Security
- Thomas Lumberg Jr. - SWAT Commander
- Kovar McClure - Air Traffic Controller
- David Rountree - Guy, the Best Man
- Susan Segal - Linda
- Paul Swanson - Peter
- Basil Wallace - Fredericks
- Michelle Wolff - E.M.T.
- Wayne Thomas Yorke - Jerry
- Jim Bentley - Marine Chaplin
- Sahar Bibiyan - Sandy Cheboloski
- Carolina Garcia - Vanessa
- Meredith Roberts Quill - Lori
- Danica Sheridan - Newlywed Bride
- Bradley Snedeker - Phil
- Jose L. Vasquez - Manuel
- Alina Andrei - Hot Girl in Bed
- Spencir Bridges - Peter DeSouza
- Roxana Brusso - Pushy Mother
- Stephanie Dees - Cal Sky Gate Agent
- Bonita Friedericy - Geraldine
- David Goldman - Disaster Dad
- Butch Klein - Turkey Man
- Thomas Mills - Ground Crew
- Scott Norris - Marine
- David Starzyk - Vince
- Jacqueline Wright - Disaster Mom
- Kristin Alcala - Passenger
- David Guzzone - LAPD Officer
- Richard Hochberg - Arte
- Larry Michelson - Businessman
- Robert Falcon Scott - Airport Police Officer
- Robert Falcon Scott - Swat Team officer
- John Siciliano - Passenger
- Charlie Stewart - Young Girl
- David Vincent - Mechanic
- David Bickford - Mr. Ludwig
- John Capodice - Mr. Vialli
- Tina Gilton - Airport Police Officer
- Stephen Grove Malloy - Nigerian Guard
- Saemi Nakamura - Maya Tagulao
- Ann Russo - Lorraine
- Joe Sabatino - Watch Commander
- Tom Schmid - Process Server
- Jackie Geary - Opal
- Clayton Norcross - Paparazzi
- Gregory Silva - Guard
- Carrie "CeCe" Cline - Sam Martinez
- Gina Garcia - Dumb Woman
- Roslyn Gentle - Woman
- John Hayden - Fred - Customs Supervisor
- Bernard Zilinskas - Duffle Bag Man
- Kevin Smith - Police Officer (uncredited)
- Mark Gordon
- Paul Redford
Heather Locklear interpreta a Harley Random en la serie.
David Paetkau hace el papel de Nick.
Capítulo disponible en las siguientes plataformas:
