- Gael García Bernal - Self
- Glenn Close - Self
- Annette Bening - Self
- Pierce Brosnan - Self
- Danny DeVito - Self
- Martin Short - Self
- Sarah Jessica Parker - Self
- Eddie Murphy - Self
- Natalie Portman - Self
- Robert Duvall - Self
- Guy Pearce - Self
- Allison Janney - Self
- Anne Hathaway - Self
- Chloë Sevigny - Self
- Norman Reedus - Self
- Tom Hanks - Self
- Maggie Gyllenhaal - Self
- Ian McKellen - Self
- Edward Norton - Self
- Andy Serkis - Self
- Liam Neeson - Self
- Ethan Hawke - Self
- Katie Holmes - Self
- Matt Dillon - Self
- Kim Cattrall - Self
- Rob Lowe - Self
- Gary Oldman - Self
- Michael Douglas - Self
- Chris Tucker - Self
- Diane Lane - Self
- Kathy Griffin - Self
- Kiefer Sutherland - Self
- Marisa Tomei - Self
- Vince Vaughn - Self
- Alessandro Nivola - Self
- Michael Shannon - Self
- Jeffrey Tambor - Self
- Jessica Lange - Self
- Sandra Bernhard - Self
- Patrick Stewart - Self
- Whoopi Goldberg - Self
- Laura Linney - Self
- Matt Damon - Self
- Casey Affleck - Self
- Debbie Harry - Self - Musical Guest
- Elijah Wood - Self
- Viggo Mortensen - Self
- Billy Bob Thornton - Self
- Reese Witherspoon - Self
- Kanye West - Self
- Orlando Bloom - Self - Guest
- Keira Knightley - Self
- Steve Buscemi - Self
- Kevin Bacon - Self
- Emmy Rossum - Self
- Robert De Niro - Self
- Kate Beckinsale - Self
- Winona Ryder - Self
- Catherine Zeta-Jones - Self
- Jake Gyllenhaal - Self
- Peter Sarsgaard - Self
- Eddie Izzard - Self
- Josh Charles - Self
- Michelle Pfeiffer - Self
- Bill Nighy - Self
- Tom Hollander - Self
- Jeffrey Wright - Self
- Lucy Liu - Self
- Amanda Peet - Self
- Common - Self
- Steve Carell - Self
- Matthew Broderick - Self
- Mary Steenburgen - Self
- Robert Downey Jr. - Self
- Tony Shalhoub - Self
- Colin Hanks - Self
- Russell Crowe - Self
- Kyle Chandler - Self
- Christian Slater - Self
- Laura Dern - Self
- Jeff Goldblum - Self
- Jason Alexander - Self
- Michael Keaton - Self
- Penélope Cruz - Self
- Kevin Spacey - Self
- Morgan Freeman - Self
- Dan Aykroyd - Self
- Riki Lindhome - Self
- Giancarlo Esposito - Self
- Rosie Perez - Self
- Kirsten Dunst - Self
- Jeff Bridges - Self
- John Goodman - Self
- Jennifer Grey - Self
- David Cross - Self
- Bruce Springsteen - Self
- George Takei - Self
- Hugh Grant - Self
- Scarlett Johansson - Self
- Matthew Goode - Self
- Brian Cox - Self
- Javier Bardem - Self
- Steve Coogan - Self
- Ben Kingsley - Self
- Stanley Tucci - Self
- Halle Berry - Self
- Benjamin Bratt - Self
- Cillian Murphy - Self
- Ewan McGregor - Self
- Brendan Gleeson - Self
- Mickey Rourke - Self
- Tilda Swinton - Self
- Clive Owen - Self
- Patricia Clarkson - Self
- Bill Murray - Self
- Conner O'Malley
Gael García Bernal hace el papel de Self.
Glenn Close interpreta a Self en la serie.
Annette Bening interpreta a Self en la serie.
Pierce Brosnan interpreta a Self en la serie.
Danny DeVito interpreta a Self en la serie.
Martin Short interpreta a Self en la serie.
Sarah Jessica Parker interpreta a Self en la serie.
Eddie Murphy interpreta a Self en la serie.
Natalie Portman interpreta a Self en la serie.
Robert Duvall hace el papel de Self.
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